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Plasmodium vivax resistance to chloroquine in Dawei, southern Myanmar [PDF]
Tropical Medicine and International Health, 2008 OBJECTIVE: To assess the efficacy of chloroquine in the treatment of Plasmodium vivax malaria in in Dawei District, southern Myanmar. METHODS: Enrolled patients at Sonsinphya clinic >6 months of age were assessed clinically and parasitologically every ...
François Nosten, Mallika Imwong
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Complicated chloroquine-resistant malaria
The Indian Journal of Pediatrics, 1985A case of chloroquine resistant mixed malaria infection is reported. Patient had associated complications: cerebral malaria; glomerulonephritis with renal failure; disseminated intravascular coagulation; gastro intestinal complications of vomiting, diarrhea and melena and pulmonary edema.
B R, Thapa, S, Mehta, L M, Singh
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Chloroquine Resistance in Plasmodium Falciparum
The American Journal of Tropical Medicine and Hygiene, 1961Summary The response to chloroquine of a strain of Plasmodium falciparum malaria from Colombia, South America, has been studied in seven patients. Six of these infections responded poorly to normal (0.6 gram, 1.5 grams) and above normal (2.1 grams) doses of the drug. The parasites were either not cleared from the blood stream or were eliminated slowly,
M D, YOUNG, D V, MOORE
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Congenital malaria with chloroquine resistance
Annals of Tropical Paediatrics, 1991A preterm infant with possible congenital clinical malaria is described. The infant developed persistent pyrexia, hyperbilirubinaemia, anaemia, increasing gastric residuals and hepatosplenomegaly from the 7th day of life. Thick and thin smears of the infant's blood were heavily loaded with various asexual stages of Plasmodium falciparum.
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Mechanism of chloroquine resistance in malaria
Parasitology Today, 1988The first system is found in the cytoplas- mic membranes of various eukaryotic cells 19, and the second is typical of excit- able cells 2°. Both systems are found in the inner mitochondrial membrane ~s. Pre- liminary experiments in our laboratory by F.
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Chloroquine-Resistant Falciparum Malaria
JAMA: The Journal of the American Medical Association, 1967To the Editor:— The Journal( 200 :886, 1967) featured an important editorial on falciparum malaria. It is certainly vital to alert the clinician to the problem of chloroquine resistance. The editorial outlines well the alternative treatment being used. I am not sure, however, that one statement is entirely warranted.
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Chloroquine Resistance in Plasmodium Berghei
The American Journal of Tropical Medicine and Hygiene, 1966Summary A strain of Plasmodium berghei was passed through mice which were maintained on a diet containing 0.008% chloroquine diphosphate and which had been treated intravenously with ethyl palmitate to destroy or diminish the phagocytic functions of the spleen.
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Management of Chloroquine-Resistant Falciparum Malaria
Archives of Internal Medicine, 1967OVER a billion people live in tropical and subtropical areas where malaria is still a serious threat. 1,2 The global eradication program has so far succeeded mostly in temperate zones. Resourceful mosquito vectors, through either physiological or behavioral resistance to residual insecticides, together with serious administrative problems, threaten the
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Altered binding of chloroquine to ferriprotoporphyrin IX is the basis for chloroquine resistance
Drug Resistance Updates, 1999The antimalarial specificity of chloroquine (CQ) stems from the saturable uptake of the drug into malaria parasites. Strains of Plasmodium falciparum that are resistant to CQ have evolved a mechanism to reduce the saturable uptake of CQ and several biochemical models have been proposed to explain this. These include an efflux process analogous to multi-
Kaylene J., Raynes +2 more
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Experimental Parasitology, 1992
The effects of tricyclic antidepressants, desipramine and imipramine, and phenothiazines, chlorpromazine and trifluoperazine, on chloroquine (CQ)-resistant and CQ-sensitive lines of P. chabaudi were examined in vivo. In mice that received daily injections of these drugs the growth of CQ-resistant and CQ-sensitive parasites was unaffected or affected ...
A, Miki +4 more
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The effects of tricyclic antidepressants, desipramine and imipramine, and phenothiazines, chlorpromazine and trifluoperazine, on chloroquine (CQ)-resistant and CQ-sensitive lines of P. chabaudi were examined in vivo. In mice that received daily injections of these drugs the growth of CQ-resistant and CQ-sensitive parasites was unaffected or affected ...
A, Miki +4 more
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