Results 211 to 220 of about 2,244,050 (276)

Phosphomimetic substitution at Ser-33 of the chloroquine resistance transporter PfCRT reconstitutes drug responses in Plasmodium falciparum. [PDF]

J Biol Chem, 2019
Sanchez CP, Moliner Cubel S, Nyboer B, Jankowska-Döllken M, Schaeffer-Reiss C, Ayoub D, Planelles G, Lanzer M.   +7 more
europepmc   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, Volume 59, Issue 9, September 2026.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

Persistence of chloroquine resistance alleles in malaria endemic countries: a systematic review of burden and risk factors. [PDF]

Malar J, 2019
Ocan M, Akena D, Nsobya S, Kamya MR, Senono R, Kinengyere AA, Obuku EA.   +6 more
europepmc   +1 more source

Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates. [PDF]

Malar J, 2020
Foguim FT, Bogreau H, Gendrot M, Mosnier J, Fonta I, Benoit N, Amalvict R, Madamet M, Wein S, Pradines B, French National Reference Centre for Imported Malaria Study Group.   +10 more
europepmc   +1 more source

PCK2 Inhibition Reverses Cisplatin Resistance of Non‐Small Cell Lung Cancer by Triggering Ferroptosis

The FASEB Journal, Volume 40, Issue 16, 31 August 2026.
Metabolic enzyme PCK2 is aberrantly upregulated in cisplatin‐resistant NSCLC cells, which inhibits ferroptosis and ultimately facilitates tumor chemoresistance. The small‐molecule inhibitor RGB‐286638 directly binds to the key R454 functional site of PCK2 protein, efficiently inhibits PCK2 expression, and rescues PCK2‐mediated ferroptosis suppression ...
Jing Liu, Ziyan Wang, Chen Gu, Yili Chen, Yang Yang, Jianjie Zhu, Yihua Zhang, Yuna Shao, Xiaodong Pang, Yujie Ge, Huiwen Qian, Jian‐an Huang, Zeyi Liu, Yuanyuan Zeng, Cheng Ji   +14 more
wiley   +1 more source

Lysosomotropism depends on glucose: a chloroquine resistance mechanism. [PDF]

Cell Death Dis, 2017
Gallagher LE, Radhi OA, Abdullah MO, McCluskey AG, Boyd M, Chan EYW.   +5 more
europepmc   +1 more source

Correction to: Polymorphisms in chloroquine resistance-associated genes in Plasmodium vivax in Ethiopia. [PDF]

Malar J, 2018
Golassa L, Erko B, Baliraine FN, Aseffa A, Swedberg G.   +4 more
europepmc   +1 more source

Analysis of Plasmodium vivax Chloroquine Resistance Transporter Mutant Isoforms. [PDF]

Biochemistry, 2017
Hassett MR, Riegel BE, Callaghan PS, Roepe PD.   +3 more
europepmc   +1 more source

An analysis of large structural variation in global Plasmodium falciparum isolates identifies a novel duplication of the chloroquine resistance associated gene. [PDF]

Sci Rep, 2019
Ravenhall M, Benavente ED, Sutherland CJ, Baker DA, Campino S, Clark TG.   +5 more
europepmc   +1 more source

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter. [PDF]

Sci Rep, 2018
Lee AH, Dhingra SK, Lewis IA, Singh MK, Siriwardana A, Dalal S, Rubiano K, Klein MS, Baska KS, Krishna S, Klemba M, Roepe PD, Llinás M, Garcia CRS, Fidock DA.   +14 more
europepmc   +1 more source