Results 191 to 200 of about 2,244,050 (276)

Atmospheric Aerosol Neurotoxicity and Parkinson's Disease: Mechanisms and Perspectives

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Schematic overview of the pathways and pathological mechanisms connecting atmospheric aerosol exposure to PD. Atmospheric aerosols, including PM2.5 and nanometer/ultrafine particles loaded with metal particles, persistent organic pollutants (POPs), polycyclic aromatic hydrocarbons (PAHs) and dioxins, enter the body predominantly via pulmonary ...
Yitian Gao, Minxiang Dong, Chenyang Duan, Xiaohan Zheng, Liming Qu   +4 more
wiley   +1 more source

Investigation of Mutations in the crt-o and mdr1 Genes of Plasmodium vivax for the Molecular Surveillance of Chloroquine Resistance in Parasites from Gold Mining Areas in Roraima, Brazil. [PDF]

Microorganisms
de Aguiar Barros J, Granja F, Abreu-Fernandes R, de Queiroz LT, E Silva DDS, Citó AC, Mocelin NKA, Daniel-Ribeiro CT, Ferreira-da-Cruz MF.   +8 more
europepmc   +1 more source

In Vitro Antiplasmodium and Chloroquine Resistance Reversal Effects of Andrographolide. [PDF]

Evid Based Complement Alternat Med, 2019
Ibraheem ZO, Majid RA, Sidek HM, Noor SM, Yam MF, Abd Rachman Isnadi MF, Basir R.   +6 more
europepmc   +1 more source

Inhibition of NHE1 Overcomes Temozolomide‐Resistance in Glioblastoma via ROS‐AKT/ERK Axis‐Mediated Autophagy Suppression

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
NHE1 inhibition via HOE‐642 suppresses autophagy through the ROS‐AKT/ERK axis, reversing temozolomide resistance in glioblastoma by disrupting the autophagy‐apoptosis balance and enhancing TMZ sensitivity in vitro and in vivo. ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with temozolomide (TMZ) resistance being a ...
Dan Li, Yuhui Li, Xuan Zheng, Zhuo Wang, Yang Wang, Jun Zhang, Jianxiong Guo, Lei Wang, Jingwu Li, Yongliang Liu, Yufeng Li   +10 more
wiley   +1 more source

An amino acid transporter AAT1 plays a pivotal role in chloroquine resistance evolution in malaria parasites

, 2022
Amambua-Ngwa A, Button-Simons KA, Li X, Kumar S, Brenneman KV, Ferrari M, Checkley LA, Haile MT, Shoue DA, McDew-White M, Tindall SM, Reyes A, Delgado E, Dalhoff H, Larbalestier JK, Amato R, Pearson RD, Taylor AB, Nosten FH, D’Alessandro U, Kwiatkowski D, Cheeseman IH, Kappe SHI, Avery SV, Conway DJ, Vaughan AM, Ferdig MT, Anderson TJC.   +27 more
europepmc   +1 more source

Lanthionine Ketenamine Derivative Enhances Early Functional Recovery Following Skeletal Muscle Ischemia‐Reperfusion Injury Through Modulation of Autophagy and Oxidative Stress

Journal of Orthopaedic Research, Volume 44, Issue 9, September 2026.
ABSTRACT Ischemia‐reperfusion injury (IRI) induces skeletal muscle damage through oxidative stress, impaired autophagy, and satellite cell (SC) dysfunction, ultimately compromising regenerative capacity and functional recovery. We investigated whether the naturally occurring autophagy‐stimulating compound 2‐n‐hexyl lanthionine ketenamine phosphonate (2‐
Valentina Barrera, Jose H. Treviño III, Travis T. Denton, Blake B. Rasmussen, Christopher Rathbone, Yulieth Soto, Maria A. Gonzalez Porras, Hugo Giambini   +7 more
wiley   +1 more source

My Love Story With HIFs in the Disc: A Journey to the Humboldt Research Award

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACT The intervertebral disc is a prime example of tissue adaptation to metabolic and mechanical extremes. As the largest avascular organ in the human body, the disc and the central nucleus pulposus (NP) endure constant compressive loading while sustaining a hypoxic, relatively acidic, and hyperosmotic microenvironment that would be inhospitable to
Makarand V. Risbud
wiley   +1 more source

Antimalarial agents: mechanism of chloroquine resistance [PDF]

Antimicrobial Agents and Chemotherapy, 1988
D J, Krogstad, P H, Schlesinger, B L, Herwaldt   +2 more
openaire   +2 more sources

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Unraveling Key Chloroquine Resistance-Associated Alleles Among Plasmodium falciparum Isolates in South Darfur State, Sudan Twelve Years After Drug Withdrawal. [PDF]

Infect Drug Resist
Magboul AM, Nour BYM, Tamomh AG, Abdul-Ghani R, Albushra SM, Eltahir HB.   +5 more
europepmc   +1 more source