Results 181 to 190 of about 2,436,233 (271)

Optimization of loop mediated isothermal amplification assay (LAMP) for detection of chloroquine resistance in P. vivax malaria. [PDF]

Sci Rep
Kaur D, Kaur U, Bhusal CK, Tak V, Sehgal R.   +4 more
europepmc   +1 more source

Selective AUTAC‐mediated ATP7B degradation unlocks cuproptosis vulnerability in pancreatic ductal adenocarcinoma

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
ATP7B is aberrantly upregulated in PDAC cells, contributing to the maintenance of copper homeostasis. We designed ATAUTAC, a targeted autophagy‐dependent degradation molecule that selectively eliminates ATP7B. By disrupting copper balance, ATAUTAC sensitizes PDAC cells to cuproptosis, thereby amplifying copper‐induced metabolic stress and effectively ...
Zihan Zhang, Min Li, Jiale Feng, Jian‐Ang Li, Lei Zhang   +4 more
wiley   +1 more source

Rapid and supersensitive allele detection of Plasmodium falciparum chloroquine resistance via a Pyrococcus furiosus argonaute-triggered dual-signal biosensing platform. [PDF]

Parasit Vectors
Chen L, Chen W, Wei H, Lin W, Zhang C, Hu H, Wang C, Chen J, Liang X, Zhu D, Wang J, Lin Z, Wei Y, Li J, Lin M.   +14 more
europepmc   +1 more source

Epigenetic silencing of PDLIM4 promotes colorectal cancer by impairing BTF3 autophagic degradation and activating PI3K/Akt signalling

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
• DNMT3A‐mediated PDLIM4 promoter hypermethylation is an early event in colorectal tumorigenesis. • Restoring PDLIM4 suppresses CRC proliferation and stemness while promoting apoptosis in vitro and in vivo. • PDLIM4 promotes the autophagic‐lysosomal degradation of BTF3 and restrains PI3K/Akt signalling.
Jiaxing Wang, Chuan‐Guo Guo, Lingyu Qi, Songyuan Hou, Boshen Lin, Tong Ye, Ye Zong, Shutian Zhang, Nan Zhang, Peng Li, Si Liu   +10 more
wiley   +1 more source

γ‐T3 Increases the Sensitization of Gastric Cancer Cells to OXA by a Regulation of ARHGAP29

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
γ‐T3 combined with oxaliplatin (OXA) inhibited the proliferation of gastric cancer cells by induction autophagy via ARHGAP29/GSK‐3β/β‐Catenin pathways. γ‐T3 combined with low‐dose of OXA could exert synergistic effects on induction autophagy‐related gastric cancer cell death, which is partially mediated by down‐regulation of the ARHGAP29/GSK‐3β/β ...
Hao Zhu, Fa‐Lin Wang, Shuang Zhang, Ting‐Ting Yang, Guang‐Qiang Gao, Hong Tian, Li Xue, Hong‐Wei Dong, Qi Wang, Shu‐Jun Zhang, Ming Liu, Jia‐Ren Liu   +11 more
wiley   +1 more source

Investigation of Mutations in the crt-o and mdr1 Genes of Plasmodium vivax for the Molecular Surveillance of Chloroquine Resistance in Parasites from Gold Mining Areas in Roraima, Brazil. [PDF]

Microorganisms
de Aguiar Barros J, Granja F, Abreu-Fernandes R, de Queiroz LT, E Silva DDS, Citó AC, Mocelin NKA, Daniel-Ribeiro CT, Ferreira-da-Cruz MF.   +8 more
europepmc   +1 more source

Empagliflozin Modulates Apoptosis and Autophagy Pathways in Lung Cancer Through Network Pharmacology and In Vitro Analysis

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
An integrated computational and in vitro approach was used to investigate the anticancer activity of empagliflozin (EMPA) in A549 and HOP‐92 lung cancer cells and its interaction with hydroxychloroquine (HCQ). Network pharmacology identified 239 shared EMPA–lung cancer targets, while molecular docking predicted favorable interactions with ANXA8, SQSTM1/
Ola A. El‐Feky, Sara M. Hamouda, Manar Mohammed El Tabaa, Sally E. Abu‐Risha, Ahmed B. M. Mehany, Othman F. Abdelzaher, Samar A. El‐Adawy   +6 more
wiley   +1 more source

An amino acid transporter AAT1 plays a pivotal role in chloroquine resistance evolution in malaria parasites

, 2022
Amambua-Ngwa A, Button-Simons KA, Li X, Kumar S, Brenneman KV, Ferrari M, Checkley LA, Haile MT, Shoue DA, McDew-White M, Tindall SM, Reyes A, Delgado E, Dalhoff H, Larbalestier JK, Amato R, Pearson RD, Taylor AB, Nosten FH, D’Alessandro U, Kwiatkowski D, Cheeseman IH, Kappe SHI, Avery SV, Conway DJ, Vaughan AM, Ferdig MT, Anderson TJC.   +27 more
europepmc   +1 more source

Current advances in 2025: A critical review of selected topics by the Association for the Advancement of Blood and Biotherapies (AABB) Clinical Transfusion Medicine Committee

Transfusion, EarlyView.
Nabiha H. Saifee, Jennifer Andrews, Mary Berg, Stella T. Chou, Mischa Covington, Elizabeth P. Crowe, Ruchika Goel, Juliana A. Guarente, Tina Ipe, Jeremy W. Jacobs, Jessica Jacobson, Cyril Jacquot, Jenna Khan, Thane A. Kubik, Theodros Mamo, Michael F. Murphy, Kerry O'Brien, Monica B. Pagano, Anil K. Panigrahi, Jacqueline N. Poston, Scott E. Potter, Simon J. Stanworth, Moritz Stolla, Alyssa Ziman, Ryan A. Metcalf   +24 more
wiley   +1 more source

Sepsis: Epidemiology, Pathophysiology, and Management

MedComm, Volume 7, Issue 11, November 2026.
Sepsis remains a major global health burden characterized by substantial geographical heterogeneity and a considerable disease burden in China. Its pathophysiology reflects an interconnected network involving excessive inflammation, oxidative stress, immune imbalance and immunoparalysis, mitochondrial damage, endothelial injury, gut dysbiosis ...
Guang‐Tao Pan, Yu Deng, Lin‐Rui Ma, Yu‐Tong Li, Yu Qian, Yi‐Hua Ma, Hai‐Wei Rao, Yi‐Zhun Zhu, Pei‐Yu Yan   +8 more
wiley   +1 more source