Results 171 to 180 of about 2,436,233 (271)

METTL7B‐Mediated m6A Modification of PLEKHA4 Suppresses Ferroptosis via Reducing AURKA Ubiquitination to Promote Papillary Thyroid Cancer Progression

Cancer Medicine, Volume 15, Issue 11, November 2026.
In PTC cells, METTL7B stabilizes PLEKHA4 mRNA through m6A modification; upregulated PLEKHA4 binds KLHL12 and inhibits KLHL12‐mediated ubiquitination and degradation of AURKA, thereby stabilizing AURKA protein. Elevated AURKA suppresses ferroptosis by upregulating GPX4 and xCT while downregulating ACSL4, leading to ferroptosis resistance and enhanced ...
Wei Lin, Kunlin Wu, Jinshu Chen, Zhaomei Yu, Huihao Zhang, Xiangjin Chen   +5 more
wiley   +1 more source

Molecular basis of the functional conflict between chloroquine and peptide transport in the Malaria parasite chloroquine resistance transporter PfCRT. [PDF]

Nat Commun
Tanner JD, Richards SN, Corry B.
europepmc   +1 more source

Divergent Roles of PIK3C3 in KRAS‐Wild‐Type and KRAS‐Mutant Advanced Colorectal Cancer: Implications for 5‐Fluorouracil Sensitivity and Prognosis

Cancer Medicine, Volume 15, Issue 11, November 2026.
PIK3C3 plays divergent roles in KRAS‐WT and KRAS‐mutant CRCs, viz. targeting PIK3C3 suppresses KRAS/ERK pathway in KRAS‐WT CRC, while enhancing 5‐FU sensitivity in KRAS‐mutant CRC. ABSTRACT Introduction Phosphatidylinositol 3‐kinase catalytic subunit type 3 (PIK3C3) is central to autophagy, which supports cancer adaptation to environmental stresses and
Chien‐An Chu, Nan‐Haw Chow, Jiu‐Yao Wang, Chen Chang, Peng‐Chan Lin, Yu‐Min Yeh, Bo‐Wen Lin, Yi‐Wen Wang, Yun‐Hao Dai, Yi‐Lin Chen, Po‐Chuan Chen, Shang‐Hung Chen, Ren‐Hao Chan, Chung‐Liang Ho, Che‐Wei Hsu, Chung‐Ta Lee   +15 more
wiley   +1 more source

Deletion of the chloroquine resistance transporter gene confers reduced piperaquine susceptibility to the rodent malaria parasite Plasmodium berghei. [PDF]

Antimicrob Agents Chemother
Hirai M, Arai M, Hayamichi S, Uchida A, Sudo M, Kubota R, Shinzawa N, Mita T.   +7 more
europepmc   +1 more source

Polymorphisms in Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and multidrug-resistant gene 1 (Pfmdr-1) in Nigerian children 10 years post-adoption of artemisinin-based combination treatments. [PDF]

Int J Parasitol, 2021
Kayode AT, Akano K, Ajogbasile FV, Uwanibe JN, Oluniyi PE, Bankole BE, Eromon PJ, Sowunmi A, Folarin OA, Volkman SK, McInnis B, Sabeti P, Wirth DF, Happi CT.   +13 more
europepmc   +1 more source

Unraveling Key Chloroquine Resistance-Associated Alleles Among Plasmodium falciparum Isolates in South Darfur State, Sudan Twelve Years After Drug Withdrawal

Abdalmoneim M Magboul,1 Bakri YM Nour,2 Abdelhakam G Tamomh,1 Rashad Abdul-Ghani,3,4 Sayed Mustafa Albushra,5 Hanan Babiker Eltahir6 1Department of Parasitology & Medical Entomology, Faculty of Medical Laboratory Sciences, University of El Imam El Mahdi,
Abdul-Ghani R, Magboul AM, Albushra SM, Tamomh AG, Nour BY, Eltahir HB   +5 more
core  

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

A CRISPR homing screen finds a chloroquine resistance transporter-like protein of the Plasmodium oocyst essential for mosquito transmission of malaria. [PDF]

Nat Commun
Balakrishnan A, Hunziker M, Tiwary P, Pandey V, Drew D, Billker O.   +5 more
europepmc   +1 more source

Epidemiology of malaria and chloroquine resistance in Mizoram, northeastern India, a malaria-endemic region bordering Myanmar. [PDF]

Malar J, 2020
Zomuanpuii R, Hmar CL, Lallawmzuala K, Hlimpuia L, Balabaskaran Nina P, Senthil Kumar N.   +5 more
europepmc   +1 more source

FSP1 as the convergent hub of autophagy and ubiquitination governing ferroptosis in monocrotaline‐induced pulmonary arterial hypertension

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Background: The crosstalk between autophagy and ferroptosis in pulmonary arterial hypertension (PAH) remains unclear. We investigated the role of FSP1 as a critical link between these processes. Methods and Findings: Mechanistically, we identified that FSP1 degradation is dually regulated by NBR1‐mediated autophagic flux and RNFT1‐dependent K63‐linked ...
Dandan Chen, Qi Jin, Lei Zhang, Wenzhi Pan, Daxin Zhou, Junbo Ge, Lihua Guan   +6 more
wiley   +1 more source