Results 201 to 210 of about 2,244,050 (276)

Plasmodium vivax chloroquine resistance links to pvcrt transcription in a genetic cross. [PDF]

Nat Commun, 2019
Sá JM, Kaslow SR, Moraes Barros RR, Brazeau NF, Parobek CM, Tao D, Salzman RE, Gibson TJ, Velmurugan S, Krause MA, Melendez-Muniz V, Kite WA, Han PK, Eastman RT, Kim A, Kessler EG, Abebe Y, James ER, Chakravarty S, Orr-Gonzalez S, Lambert LE, Engels T, Thomas ML, Fasinu PS, Serre D, Gwadz RW, Walker L, DeConti DK, Mu J, Bailey JA, Sim BKL, Hoffman SL, Fay MP, Dinglasan RR, Juliano JJ, Wellems TE.   +35 more
europepmc   +1 more source

Pediatric Use of Off‐Label Medicines and Nonevidence‐Based Supplements for COVID‐19: Findings From the 2015 Pelotas Birth Cohort Study (Brazil)

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 9, September 2026.
ABSTRACT Purpose Pediatric off‐label medicine use increased during the COVID‐19 pandemic, exposing children to nonevidence‐based treatments. We described the use of nonevidence‐based COVID‐19 medicines and supplements among children from the 2015 Pelotas Birth Cohort, according to sociodemographic and health‐related characteristics.
Andréa Dâmaso Bertoldi, Fernando Silva Guimarães, Alexandra Crispim Boing, Marysabel Pinto Telis Silveira, Pedro Curi Hallal, Mariângela Freitas da Silveira   +5 more
wiley   +1 more source

Reversal of Chloroquine Resistance of Plasmodium vivax in Aotus Monkeys. [PDF]

Antimicrob Agents Chemother, 2018
Obaldia N, Milhous WK, Kyle DE.
europepmc   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Emerging Chemical Upcycling and Repurposing Strategies for Waste Pharmaceuticals

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
What could be done with pharmaceutical waste from a circular chemistry perspective? A literature survey was conducted using the terms “recycling”, “upcycling”, “reuse”, “repurposing”, “pharmaceutical”, “expired drug”, “expired medicine”, “unused drug” and “unused medicine” in the databases Scopus, Web of Science and Periódicos CAPES to answer this ...
Letícia Ribeiro Magalhães, Lourena Mafra Veríssimo, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão   +3 more
wiley   +1 more source

En-route to the 'elimination' of genotypic chloroquine resistance in Western and Southern Zambia, 14 years after chloroquine withdrawal. [PDF]

Malar J, 2019
Sitali L, Mwenda MC, Miller JM, Bridges DJ, Hawela MB, Chizema-Kawesha E, Chipeta J, Lindtjørn B.   +7 more
europepmc   +1 more source

Combined MEK1/2 and Autophagy Inhibition Suppresses Tumor Growth via STING‐Mediated Type I Interferon Response in iCCA

Cancer Science, Volume 117, Issue 9, Page 2413-2425, September 2026.
Through bioinformatic analyses, iCCA cell models, and in vivo xenograft experiments, we show that autophagy inhibition sensitizes iCCA to MEK1/2 blockade by enhancing STING‐dependent type I interferon signaling. These findings support combined MEK1/2 and autophagy inhibition as a promising therapeutic strategy for iCCA. ABSTRACT The RAF–MEK–ERK pathway
Chengqiang Sun, Zheng Gao, Enfu Dong, Liangxia Ding, Shanru Feng, Jiafeng Chen, Pascal Kwangwari, Yinghong Shi, Weiren Liu, Xin Zhang, Ao Huang, Jian Zhou, Sheng Wang, Jia Fan, Xiutao Fu, ZhenBin Ding   +15 more
wiley   +1 more source

Hypericin Suppresses Liver Cancer Through Autophagic Degradation of AKT and Eliciting Antitumor Immune Response

Cancer Science, Volume 117, Issue 9, Page 2567-2585, September 2026.
Hypericin induces autophagic AKT degradation by promoting AKT‐HSPA5 interaction in an S473 phosphorylation‐dependent manner, suppressing HCC growth. It enhances CD8+ T cell‐mediated antitumor immunity and synergizes with anti‐PD‐L1 therapy, showing favorable safety for HCC treatment. ABSTRACT Hepatocellular carcinoma (HCC) is the most prevalent primary
Sien Ma, Qianqian Xu, Mengjuan Zhu, Xianming Ge, Jian Xu, Yan Pan, Mengli Wang, Yuting Zhu, Aoxuan Xu, Hanmeng Liu, GuangHai Xiang, Weipeng Gong, Bao Zhao   +12 more
wiley   +1 more source

Role of Toxoplasma gondii Chloroquine Resistance Transporter in Bradyzoite Viability and Digestive Vacuole Maintenance. [PDF]

mBio, 2019
Kannan G, Di Cristina M, Schultz AJ, Huynh MH, Wang F, Schultz TL, Lunghi M, Coppens I, Carruthers VB.   +8 more
europepmc   +1 more source

Design and Synthesis of Novel 1,2,3‐Triazole Conjugates Featuring Hydroxamic Acid and Sulfonamide Moieties: Exploring Dual Pharmacophores for Enhanced Biological Activity

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Design and synthesis of novel 1,2,3‐triazole conjugates featuring hydroxamic acid and sulfonamide moieties: exploring dual pharmacophores for enhanced biological activity. ABSTRACT A new series of N‐hydroxy‐1‐(4‐(aryl sulfonamido)phenyl)‐1H‐1,2,3‐triazole‐4‐carboxamide derivatives (8a‐j) were synthesized through a concise multistep route integrating ...
Dineshkumar Pagar, Ranjay Shaw, Hemant Suryavanshi, Dhanji Rajani, Sudhakar Patil   +4 more
wiley   +1 more source