Results 81 to 90 of about 82,153 (289)

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis

ChemistryOpen, EarlyView.
The study demonstrated that thidiazine compounds potentiated the action of antibiotics. The compounds associated with norfloxacin against S. aureus showed greater significance in relation to the other medications. The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of ...
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo   +15 more
wiley   +1 more source

Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis

BMC Complementary and Alternative Medicine, 2017
Background The hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereotypic behaviours suggesting ...
Patrick Amoateng, Samuel Adjei, Dorcas Osei-safo, Kennedy K. E. Kukuia, Emelia Oppong Bekoe, Thomas K. Karikari, Samuel B. Kombian   +6 more
doaj   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Electrochemical Behaviour and Sensing of Chlorpromazine at Polymer‐Free Kaolin‐Based Nanosodalite and Nanosodalite‐Graphene Foam Film modified Glassy Carbon Electrodes

ChemElectroChem
A nanosodalite (SOD) was synthesized utilizing Cameroonian kaolin and then used to prepare a nanocomposite (SOD‐GF) with graphene foam (GF). The as‐synthesized materials were characterized using X‐ray diffractometry (XRD), Fourier transform‐infrared (FT ...
Firmin Parfait Tchoumi, Cyrille Ghislain Fotsop, Guy Bertrand Tamne, Henrietta W. Langmi, Justin Claude Kemmegne‐Mbouguen, Emmanuel Ngameni   +5 more
doaj   +1 more source

Influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury [PDF]

Acta Cirúrgica Brasileira, 2016
PURPOSE: To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury. METHODS: Sixteen Wistar rats - split in two groups - have been used: control group, receiving 3 mg/kg isotonic saline solution ...
Júlio César Foiatto, Nicolau Gregori Czeczko, Eduardo Gabriel Guerber Wietzikoski, Osvaldo Malafaia, Thadeu Brenny Filho, André Matos de Oliveira, Regina de Paula Xavier Gomes   +6 more
doaj   +2 more sources

Comparative effects of Rauwolfia vomitoria and chlorpromazine on social behaviour and pain

North American Journal of Medicine and Science, 2011
Background: Rauwolfia vomitoria has been used in Nigeria to manage psychiatric disorders despite orthodox medicine. Aims: This research was therefore aimed at comparing the effects of R.
S. Bisong, R. Brown, E. Osim
semanticscholar   +1 more source

Antipsychotic dose escalation as a trigger for Neuroleptic Malignant Syndrome (NMS): literature review and case series report [PDF]

, 2012
Background: “Neuroleptic malignant syndrome” (NMS) is a potentially fatal idiosyncratic reaction to any medication which affects the central dopaminergic system. Between 0.5% and 1% of patients exposed to antipsychotics develop the condition.
AL Pelonero, BD Berman, D Berardi, D Bereardi, D Heyland, Daniel J Smith, Daniel Martin, F-GB Pajonk, H Itoh, J Ananth, J Delay, J Gill, JF Patterson, JN Trollor, JR Strawn, Julie Langan, K Otani, KL Hall, LF Viejo, LS Friedman, M Dave, MJ Bhanushali, P Adnet, P Sachdev, P Sachdev, PE Keek, PF Buckley, PI Rosebush, PJ Alexander, Polash Shajahan, RJ Gurrera, RJ Gurrera, RW Baker, S Caroff, S Madakasira   +34 more
core   +3 more sources

Mitophagy and Bip–PERK–eIF2α–ATF4 Axis‐Mediated ER Stress Mediate Miriplatin‐Loaded Liposome's Anti‐Colorectal Cancer Action

Cell Proliferation, EarlyView.
LMPt enters the cell mainly through caveolin‐mediated endocytosis, and then fuses with endosomes and lysosomes to deliver MPt to mitochondria and the endoplasmic reticulum to induce mitophagy based on the fusion of lysosomes and mitochondria, and endoplasmic reticulum stress and subsequent apoptosis via the Bip–PERK–eIF2α–ATF4 axis to exert an anti ...
Cong Zhao, Yuhan Qiu, Xiaowei Wang, Mengyan Wang, Li Liu, Xiaojun Zhao, Zixiang Gao, Rongguang Shao, Guimin Xia, Wuli Zhao   +9 more
wiley   +1 more source

Biochemical Pathways Triggered by Antipsychotics in Human Oligodendrocytes: Potential of Discovering New Treatment Targets

Frontiers in Pharmacology, 2019
Schizophrenia is a psychiatric disorder that affects more than 21 million people worldwide. It is an incurable disorder and the primary means of managing symptoms is through administration of pharmacological treatments, which consist heavily of ...
Caroline Brandão-Teles, Valéria de Almeida, Juliana S. Cassoli, Juliana S. Cassoli, Daniel Martins-de-Souza, Daniel Martins-de-Souza, Daniel Martins-de-Souza   +6 more
doaj   +1 more source

D1/D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2

The FEBS Journal, EarlyView.
Activation of dopamine receptor D1 (D1R) stimulates PKA and ERK pathways via dissociation of stimulatory and olfactory G protein alpha subunits (Gαs/olf). PKA relieves striatal‐enriched protein tyrosine phosphatase (STEP) inhibition of ERK, promoting cyclic adenosine monophosphate response element‐binding protein (CREB)‐driven transcription of ...
Kevin Chua, Yee Song Chong, Sreedharan Sajikumar   +2 more
wiley   +1 more source