Results 81 to 90 of about 51,092 (216)

Mortality and Associated Factors Among Adult Tetanus Patients Admitted at Public Hospitals in Bahir Dar City, Ethiopia: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Tetanus, caused by Clostridium tetani, results in rigor spasms and remains as major cause of mortality in areas with poor vaccination and sanitation. Mortality has been cited to be 20%–55% in Ethiopia, possibly due to variation in healthcare, immunization, and intensive care access.
Mulugeta Tesfaw, Hailemariam Awoke Engedaw, Teshome Alene, Zemenu Shiferaw Yadita   +3 more
wiley   +1 more source

Chlorpromazine activates cGAS-STING signaling and reprograms the immune response in glioblastoma

Frontiers in Immunology
BackgroundGlioblastoma (GBM), the most common and aggressive primary brain tumor in adults, poses a formidable therapeutic challenge, due to its intrinsic radio- and chemoresistance and its ability to create a hostile, immunosuppressive tumor ...
Giulia Fanelli, Luisa Gesualdi, Barbara Ascione, Francesca Paolini, Lucrezia Gambardella, Andrea Sacconi, Marco G. Paggi, Paola Matarrese, Claudia Abbruzzese   +8 more
doaj   +1 more source

The Fatty Acid Transporter CD36 Mediates Uptake, Biodistribution, and Cardioprotection by Small Extracellular Vesicles From HEK293 Cells

Journal of Extracellular Vesicles, Volume 15, Issue 3, March 2026.
ABSTRACT Extracellular vesicles (EVs) are nanoscale carriers of bioactive molecules that mediate intercellular communication. Small EVs (sEVs) have shown cardioprotective effects in models of myocardial infarction (MI), but their uptake and biodistribution remain incompletely understood.
Elias Sulaiman, Derek M. Yellon, Sean M. Davidson   +2 more
wiley   +1 more source

Pathology of single dose cadmium toxicity and investigations of protective effect of simultaneous chlorpromazine administrations in rats [PDF]

Eurasian Journal of Veterinary Sciences
Aim: This study was carried out to determine pathology of cadmium toxicity and protective effects of chlorpromazine in rats, simultaneously. Materials and Methods: Totally 64 Sprague-Dawley rats were divided into four equal groups.
Tuna Erdem, Fatih Hatipoğlu
doaj  

Electrochemical oxidation of Fe (II) using chlorpromazine drug at boron-doped diamond electrode: application to in vivo mechanism study interaction of chlorpromazine on hemoglobin iron and evaluation of some biomolecules

Materials Research Express
In this study, the electrochemical properties of aqueous chlorpromazine hydrochloride (CPZ) in the presence of Fe (II) were investigated by cyclic voltammetry at a boron-doped diamond (BDD) electrode.
Nader Amini, Kazhal Naderi, Abbas Ahmadi, Kambiz Hassanzadeh, Mohammad-Nazir Menbari, Mohammad Abdi, Ebrahim Ghaderi, Mohammad-Rezgar Zarehbin   +7 more
doaj   +1 more source

Macromolecule‐Loaded Hybrid Extracellular Vesicles via Ionic Lipid–Based Post‐Loading for Intracellular Delivery: Functional Evaluation for Neurodegenerative Therapy

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Extracellular vesicles (EVs) are natural carriers that show promise as drug delivery systems (DDS). We developed a non‐invasive post‐loading method to encapsulate macromolecules in EVs using our proprietary ionic lipid base (ILB), which enables electrostatically driver hybridisation without disrupting EV structure.
Lin Cui, Fumiyasu Ono, Tomoko Ichinose, Masahiro Goto, Kohei Ishihama   +4 more
wiley   +1 more source

Determination of Trace Levels of Nitrite in Beverages Samples Through Micellar Improved Catalytic Kinetic Spectrophotometry

Cumhuriyet Science Journal, 2017
In this study, a simple and sensitive catalytic kineticspectrophotometry method for determination of nitrite has been described. Themethod is based on the oxidation of chlorpromazine by nitrite in presence ofmixed surfactants in acidic medium, which ...
Adil Elik, Nail Altunay, Ramazan Gürkan
doaj   +1 more source

Safety of MRI Examinations Under Sedation: A Nationwide Survey in Japan

Journal of Magnetic Resonance Imaging, Volume 63, Issue 3, Page 798-810, March 2026.
ABSTRACT Background MRI is performed under sedation for patients requiring immobility or for those already sedated for clinical management. Although specialist guidelines advocate for anesthesiologist‐led care, non‐anesthesiologist‐led adult sedation is a common practice worldwide. Furthermore, the increase in risk attributable to sedation has not been
Shiori Amemiya, Masako Kataoka, Tsukasa Doi, Toshinori Hirai, Takayuki Obata, Kagayaki Kuroda   +5 more
wiley   +1 more source

An Engineered Extracellular Vesicle With Enhanced Tumor and Lymph Nodes Targeting as siRNA Delivery System for Robust Tumor Immunotherapy

MedComm, Volume 7, Issue 3, March 2026.
Simple incubation with DP7‐C enables the generation of extracellular vesicles (DP‐EVs) with enhanced both tumor and lymph nodes targeting properties. DP‐EVs/siPD‐L1 can effectively inhibit tumor growth and greatly prolong the survival of tumor bearing mice through immune response activation and tumor microenvironment reprogramming.
Yusi Wang, Rui Zhang, Xuejing Zhou, Lin Tang, Die Hu, Yibing Zhang, Yuling Yang, Bailing Zhou, Li Yang   +8 more
wiley   +1 more source

A multipurpose Voltammetric Sensor for the Determination of Chlorpromazine in Presence of Acetaminophen, Uric Acid, Dopamine and Ascorbic Acid

International Journal of Electrochemical Science, 2012
We report the fabrication and characterization of a voltammetric sensor for the determination of chlorpromazine (CPM) based on multiwalled carbon nanotube-polyethyleneimine (MWCNT-PEI) composite modified glassy carbon electrode (GCE).
Binesh Unnikrishnan, Pei-Chi Hsu, Shen-Ming Chen   +2 more
doaj   +1 more source