Results 81 to 90 of about 79,424 (330)

Influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury [PDF]

Acta Cirúrgica Brasileira, 2016
PURPOSE: To analyze the influence of chlorpromazine on renal histology of rats submitted to ischemia and reperfusion injury. METHODS: Sixteen Wistar rats - split in two groups - have been used: control group, receiving 3 mg/kg isotonic saline solution ...
Júlio César Foiatto, Nicolau Gregori Czeczko, Eduardo Gabriel Guerber Wietzikoski, Osvaldo Malafaia, Thadeu Brenny Filho, André Matos de Oliveira, Regina de Paula Xavier Gomes   +6 more
doaj   +2 more sources

Effects of antipsychotics on bone mineral density and prolactin levels in patients with schizophrenia: a 12-month prospective study

, 2014
Objective: Effects of conventional and atypical antipsychotics on bone mineral density (BMD) and serum prolactin levels (PRL) were examined in patients with schizophrenia.Methods: One hundred and sixty-three first-episode inpatients with schizophrenia ...
Cao, Bingyu, Hou, Ruihua, Jian, Jia, Mi, Guolin, Qiu, Huimin, Tang, Maoqin, Wang, Mengxin   +6 more
core   +1 more source

Antipsychotics and Torsadogenic Risk: Signals Emerging from the US FDA Adverse Event Reporting System Database [PDF]

, 2013
Background: Drug-induced torsades de pointes (TdP) and related clinical entities represent a current regulatory and clinical burden. Objective: As part of the FP7 ARITMO (Arrhythmogenic Potential of Drugs) project, we explored the publicly available US ...
A Bate, A Clarke, A Pariente, AK Chung, Ariola Koci, B Darpo, BJ Drew, C Meyer-Massetti, DM Roden, DW Hough, E Poluzzi, E Poluzzi, E Poluzzi, E Raschi, E Raschi, Edoardo Spina, Elijah R. Behr, Elisabetta Poluzzi, Emanuel Raschi, EP Puijenbroek van, ER Behr, F Ponti De, F Ponti De, F Rani, Fabrizio De Ponti, GC Alexander, GK Isbister, H Verdoux, J Nielsen, J Papay, K Jolly, K Titier, LC Wittkampf, LS Schneider, Miriam Sturkenboom, NP Tatonetti, P Kannankeril, P Manu, P Vigneault, RC Owens Jr, RR Shah, S Dhillon, S Hennessy, S Kongsamut, S Leucht, SM Straus, Ugo Moretti, W Crumb, W Crumb, WA Ray, WA Ray, WJ Crumb Jr, WP Stephenson, Y Suzuki   +53 more
core   +3 more sources

Nanofabricated Bacterial Cell Walls with Intrinsic Peroxidase‐Mimicking and Sonodynamic Activities for Cancer Combination Treatment

Advanced Science, EarlyView.
Bacterial cell walls (CWs) extracted from Porphyromonas gingivalis are nanofabricated to form the CW vesicles (CWV), which have intrinsic peroxidase‐mimicking and sonodynamic activities due to the presence of µ‐oxo bisheme and meanwhile retain a large amount of lipopolysaccharide.
Meng Yang, Yang Meng, Junling Li, Liya Bai, Yuanyuan Cheng, Yuanyuan Liu, Mingxin Cao, Xiaoying Yang, Yinsong Wang, Yang Liu   +9 more
wiley   +1 more source

Proteasome localization and activity in pig brain and in vivo small molecule screening for activators

Frontiers in Cellular Neuroscience
IntroductionLoss of proteasome function, proteinopathy, and proteotoxicity may cause neurodegeneration across the human lifespan in several forms of brain injury and disease.
Adriana Amrein Almira, May W. Chen, Nagat El Demerdash, Cameron Javdan, Dongseok Park, Jennifer K. Lee, Lee J. Martin, Lee J. Martin, Lee J. Martin, Lee J. Martin   +9 more
doaj   +1 more source

Strain-dependent porcine circovirus type 2 (PCV2) entry and replication in T-lymphoblasts [PDF]

, 2019
Porcine circovirus type 2 (PCV2) is the etiological agent of PCV2-associated diseases (PCVAD). PCV2 targets lymphoblasts, and pigs suffering from PCVAD display lymphocyte depletion in lymphoid tissues. PCV2 infection of lymphoblasts has not been studied.
Nauwynck, Hans, Van Renne, Nicolaas, Wei, Ruifang   +2 more
core   +1 more source

Clozapine v. chlorpromazine in treatment-naive, first-episode schizophrenia: 9-year outcomes of a randomised clinical trial.

The British journal of psychiatry : the journal of mental science, 2011
BACKGROUND The differential effects of so-called 'first- and second generation' antipsychotic medications, when given in the first episode, on the long-term outcome of schizophrenia remain to be elucidated.
R. Girgis, M. Phillips, Xiaodong Li, Kejin Li, Huiping Jiang, Chengjing Wu, N. Duan, Yajuan Niu, J. Lieberman   +8 more
semanticscholar   +1 more source

Bis[1]benzothieno[1,4]thiazine‐S‐oxides–Luminescence of the Anti‐Anti‐Regioisomer

Asian Journal of Organic Chemistry, EarlyView.
Three regioisomeric bis[1]benzothieno[1,4]thiazine‐S‐oxides were synthesized by mild oxidation. Crystal structures reveal S‐extra‐oxide, N‐intra conformers with paired‐like substructures, and intermolecular distances as low as 3.30 Å. UV–vis absorption and emission spectroscopy identifies the anti‐anti‐regioisomer as a strong blue light emitter ...
Simone T. Hauer, J. Maurice Pütz, Christian Ganter, Thomas J. J. Müller   +3 more
wiley   +1 more source

Gold Nanoclusters as Smart Nanoplatforms for Targeted Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
A folic acid‐targeted gold nanocluster platform is developed for tumor‐specific delivery and radiofrequency (RF)‐triggered release of doxorubicin. Enhanced uptake, nuclear localization, and therapeutic efficacy are confirmed in 2D and 3D spheroid models.
Samad Mussa Farkhani, David Rudd, Helmut Thissen, Muhammad A. Ali, Mehmet Yuce, Anna Cifuentes‐Rius, Nicolas H. Voelcker   +6 more
wiley   +1 more source

Bright light therapy as part of a multicomponent management program improves sleep and functional outcomes in delirious older hospitalized adults. [PDF]

, 2013
ObjectiveDelirium is associated with poor outcomes following acute hospitalization. A specialized delirium management unit, the Geriatric Monitoring Unit (GMU), was established.
Ancoli-Israel, Sonia, Chong, Mei Sian, Tan, Keng Teng, Tay, Laura, Wong, Yoke Moi   +4 more
core   +1 more source