Targeting the Mitochondrial Chaperone TRAP1 Alleviates Vascular Pathologies in Ischemic Retinopathy
Advanced Science, Volume 11, Issue 2, January 12, 2024.This study reveals that the mitochondrial chaperone TRAP1 is vital for stabilizing HIF1α, a key transcription factor in pathologic microvascular changes in ischemic retinopathies. Therefore, inhibiting TRAP1 genetically or pharmacologically alleviates retinal vascular pathologies by inducing HIF1α proteolytic degradation, indicating that TRAP1 can be a
So‐Yeon Kim +10 more
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Predictive In-Vitro Evaluation of Food Effect on The In-Vivo Performance of Chlorpropamide Tablet
, 2012 This study compared the disintegration time and dissolution profile of the hypoglyceamic drug product, chlorpropamide marketed in Nigeria as Chlorbinese in simulated gastric fluid (SGF), simulated intestinal fluid SIF, and in food modified gastric fluid (
Uwanta, Emaime Jimmy +4 more
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Antidiabetic Effect of Chloroform - Methanol Extract of Abrus Precatorius Linn Seed in Alloxan Diabetic Rabbit [PDF]
, 2005 The antidiabetic effect of chloroform - methanol extract of Abrus precatorious seed, was studied in alloxan diabetic rabbits. The effect was compared to that of chlorpropamide - a known antidiabetic drug in the class of sulphonylurea and a control ...
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Basal normoglycemia attained with chlorpropamide in mild diabetes.
, 1978 Sixteen adult-onset diabetics, who were thought by current criteria to be well controlled on diet alone, had substantially elevated overnight, basal plasma glucose concentrations. Chlorpropamide had a sufficiently prolonged stimulatory effect on the beta
Turner, RC, Holman, RR, Holman, Rury
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, 2017 Most diabetes mellitus patients practice self-administration of herbal products along with their conventional drugs without the knowledge of their physicians.
Benjamin O. Emikpe +7 more
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, 2004 Objective: This study was conducted to compare the potential inhibitory effect of ATP-dependent K+ channel blockers, glibenclamide and chlorpropamide on diazoxide-induced relaxation of isolated rat ileum.
J. Mohiti, A. Babaei
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Dataset: CSP-generated crystal structures of chlorpropamide
Dataset in support of the journal article 'Pushing technique boundaries to probe conformational polymorphism' to be published in Crystal Growth and Design This dataset contains: Crystal structures of the flexible drug molecule chlorpropamide,
Day, Graeme, Taylor, Christopher
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Proposal for a systematic naming convention for liamocins
Journal of Surfactants and Detergents, Volume 27, Issue 3, Page 459-461, May 2024.
Till Tiso +6 more
wiley +1 more source
Comparative Bioavailability study with two chlorpropamide tablet formulations in healthy volunteers
, 2015 Objective. The aim of this study was the assessment of the bioequivalence of two formulations (250 mg tablet) of chlorpropamide (CAS 94-20-2) in 36 healthy volunteers of both sexes.
Reyar, S +7 more
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Comparative Study Of The Hypoglycemic And Biochemical Effects Of Catharanthus Roseus (Linn) G. Apocynaceae (Madagascar Periwinkle) And Chlorpropamide (Diabenese) On Alloxan-induced Diabetic Rats [PDF]
, 2005 The effect of the aqueous extracts of Catharanthus roseus and chlorpropamide (Diabenese) on the levels of serum cholesterol, total protein, lipid peroxidation, blood glucose and liver enzymes were compared in alloxan-induced diabetic rats.
Okeke, C. U. +3 more
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