Results 51 to 60 of about 4,931 (189)

Pharmacogenetics of oral antidiabetic drugs [PDF]

, 2013
Oral antidiabetic drugs (OADs) are used for more than a half-century in the treatment of type 2 diabetes. Only in the last five years, intensive research has been conducted in the pharmacogenetics of these drugs based mainly on the retrospective register
Becker, Matthijs L., Pearson, Ewan R., Tkáč, Ivan   +2 more
core   +5 more sources

Association between chronic diseases and severe periodontal disease progression: A retrospective cohort study in a city of Japan

Journal of General and Family Medicine, Volume 26, Issue 1, Page 54-64, January 2025.
This manuscript is a study demonstrating the association between the progression of severe periodontal diseases and chronic diseases commonly addressed in primary care. We used claims data and defined the outcome as the “progression of severe periodontitis” and followed patients for 4 years.
Sayaka Nin, Yu Sun, Takami Maeno, Chihiro Nishiura, Kento Taira, Kenji Fujimoto, Jun Hamano, Sachiko Ozone, Tetsuhiro Maeno   +8 more
wiley   +1 more source

From bench to bedside: Tracing the payback forwards from basic or early clinical research – A preliminary exercise and proposals for a future study [PDF]

, 2010
EXECUTIVE SUMMARY Chapter 1 : Introduction • The members of the research team from HERG and the Wellcome Trust have conducted previous studies showing that it is possible both to assess the payback from applied health research, and to use bibliometrics
Buxton, MJ, Frame, I, Grant, J, Green, P, Hanney, S   +4 more
core  

Medications and Acute Hemolysis in G6PD‐Deficient Patients – A Real‐World Study

Clinical Pharmacology &Therapeutics, Volume 116, Issue 6, Page 1537-1543, December 2024.
Many drug labels contain precautions of use in G6PD‐deficient patients due to hemolytic concerns, but much of this is based on scarce clinical, epidemiological, or structural data. In this real‐world study, we aimed to examine if the administration of presumably risky medications for G6PD‐deficient patients was followed by hemolysis. The study is based
Naomi Gronich, Bar Rosh, Nili Stein, Walid Saliba   +3 more
wiley   +1 more source

Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis. [PDF]

, 2017
Debate exists regarding the safety of metformin and the risk of metformin-associated lactic acidosis, particularly in the setting of kidney dysfunction.
Kalantar-Zadeh, Kamyar, Rhee, Connie M
core   +1 more source

Glyburide use is associated with a greater likelihood of mortality or rehospitalization after acute coronary syndrome compared to gliclazide use in adults with type 2 diabetes: A cohort study

Diabetes, Obesity and Metabolism, Volume 26, Issue 11, Page 5408-5419, November 2024.
Abstract Aim To examine the likelihood of mortality or rehospitalization following acute coronary syndrome with glyburide versus gliclazide use in adults with type 2 diabetes undergoing cardiac catheterization. Research Design and Methods This retrospective cohort study used clinical data linked with administrative health data from Alberta, Canada ...
Wentong Long, Peter E. Light, Scot H. Simpson   +2 more
wiley   +1 more source

Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. [PDF]

, 2016
Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an important factor during development of diabetes.
Ahlstedt, I., Elhachmane, M., Gopel, S., Pedersen, MORTEN GRAM   +3 more
core   +1 more source

Metabolomic identification of predictive and early biomarkers of cisplatin‐induced acute kidney injury in adult head and neck cancer patients

British Journal of Clinical Pharmacology, Volume 90, Issue 8, Page 1790-1803, August 2024.
Aim Cisplatin causes acute kidney injury (AKI) in approximately one third of patients. Serum creatinine and urinary output are poor markers of cisplatin‐induced AKI. Metabolomics was utilized to identify predictive or early diagnostic biomarkers of cisplatin‐induced AKI.
Yong Jin Lim, Steven G. Xiu, M. Sara Kuruvilla, Eric Winquist, Stephen Welch, Morgan Black, Lauren N. Faught, Jasmine Lee, Michael J. Rieder, Tom D. Blydt‐Hansen, Michael Zappitelli, Bradley L. Urquhart   +11 more
wiley   +1 more source

A Repeat Random Survey of the Prevalence of Falsified and Substandard Antimalarials in the Lao PDR: A Change for the Better. [PDF]

, 2015
In 2003, a stratified random sample survey was conducted in the Lao People's Democratic Republic (Laos) to study the availability and quality of antimalarials in the private sector.
Allan, Elizabeth Louise, Culzoni, María Julia, Dwivedi, Prabha, Fernández, Facundo M, Green, Michael D, Kaur, Harparkash, Khanthavong, Maniphone, Mayxay, Mayfong, Newton, Paul N, Phonlavong, Chindaphone, Sengaloundeth, Sivong, Sichanh, Chanvilay, Swamidoss, Isabel, Tabernero, Patricia, Vilayhong, Chantala, Yeuchaixiong, Sengchanh   +15 more
core   +2 more sources

Current type 2 diabetes guidelines: Individualized treatment and how to make the most of metformin

Diabetes, Obesity and Metabolism, Volume 26, Issue S3, Page 55-74, August 2024.
Abstract Evidence‐based guidelines provide the premise for the delivery of quality care to preserve health and prevent disabilities and premature death. The systematic gathering of observational, mechanistic and experimental data contributes to the hierarchy of evidence used to guide clinical practice. In the field of diabetes, metformin was discovered
Juliana C. N. Chan, Aimin Yang, Natural Chu, Elaine Chow   +3 more
wiley   +1 more source