Results 51 to 60 of about 3,364 (147)

Predictive In-Vitro Evaluation of Food Effect on The In-Vivo Performance of Chlorpropamide Tablet [PDF]

, 2012
This study compared the disintegration time and dissolution profile of the hypoglyceamic drug product, chlorpropamide marketed in Nigeria as Chlorbinese in simulated gastric fluid (SGF), simulated intestinal fluid SIF, and in food modified gastric fluid (
Uwanta, Emaime Jimmy, Ayekormiogban, Nnamdi Jolly, Effiong, Ukpong Emmanuel, Umoren, Fabian James, Awofisayo, Sunday Olajide   +4 more
core   +1 more source

Solid solution polymorphs afford two high-soluble co-drug forms of tolbutamide and chlorpropamide

, 2023
The search for solid solutions of class-two insulin secretagogues, tolbutamide and chlorpropamide, reveals a rare case of monotropic polymorphism for the mixed crystals.
Enrico Spoletti (16714419), Vivek Verma (575280), Matteo Lusi (12346906), Chiara Cappuccino (6542351)   +3 more
core   +1 more source

Association between chronic diseases and severe periodontal disease progression: A retrospective cohort study in a city of Japan

Journal of General and Family Medicine, Volume 26, Issue 1, Page 54-64, January 2025.
This manuscript is a study demonstrating the association between the progression of severe periodontal diseases and chronic diseases commonly addressed in primary care. We used claims data and defined the outcome as the “progression of severe periodontitis” and followed patients for 4 years.
Sayaka Nin, Yu Sun, Takami Maeno, Chihiro Nishiura, Kento Taira, Kenji Fujimoto, Jun Hamano, Sachiko Ozone, Tetsuhiro Maeno   +8 more
wiley   +1 more source

Chlorpropamide treatment restores the reduced carrageenan-induced paw edema and pleural exudate volume in diabetic rats

, 2008
Objective and design: Knowing that hyperglycemia is a hallmark of vascular dysfunction in diabetes and that neonatal streptozotocin-induced diabetic rats (n-STZ) present reduced inflammatory response, we decided to evaluate the effect of chlorpropamide ...
CARVALHO, M. H., FORTES, Z. B., NIGRO, D., CUMAN, R. K. N., BERSANI-AMADO, C. A., SANTOS, R. A., PASSAGLIA, R. T., SARTORETTO, J. L., MELO, G. A., OLIVEIRA, M. A.   +9 more
core   +1 more source

Medications and Acute Hemolysis in G6PD‐Deficient Patients – A Real‐World Study

Clinical Pharmacology &Therapeutics, Volume 116, Issue 6, Page 1537-1543, December 2024.
Many drug labels contain precautions of use in G6PD‐deficient patients due to hemolytic concerns, but much of this is based on scarce clinical, epidemiological, or structural data. In this real‐world study, we aimed to examine if the administration of presumably risky medications for G6PD‐deficient patients was followed by hemolysis. The study is based
Naomi Gronich, Bar Rosh, Nili Stein, Walid Saliba   +3 more
wiley   +1 more source

The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media [PDF]

, 2016
The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium).
Zakharov, B. A., Hanfland, M., Paliwoda, D., Boldyreva, E. V., Seryotkin, Y. V., Kurnosov, A. V., Tumanov, N. A.   +6 more
core   +1 more source

Glyburide use is associated with a greater likelihood of mortality or rehospitalization after acute coronary syndrome compared to gliclazide use in adults with type 2 diabetes: A cohort study

Diabetes, Obesity and Metabolism, Volume 26, Issue 11, Page 5408-5419, November 2024.
Abstract Aim To examine the likelihood of mortality or rehospitalization following acute coronary syndrome with glyburide versus gliclazide use in adults with type 2 diabetes undergoing cardiac catheterization. Research Design and Methods This retrospective cohort study used clinical data linked with administrative health data from Alberta, Canada ...
Wentong Long, Peter E. Light, Scot H. Simpson   +2 more
wiley   +1 more source

The Effect of Serum Ca2+ Compensation on the Efficacy of Chlorpropamide in Alloxan-diabetic Rabbits

, 1992
A decrease in serum Ca2+ concentration was observed in alloxan-diabetic rabbits, with recovery of serum Ca2+ levels achieved following insulin therapy. This suggested that the diabetic condition directly relates to the decrease in serum Ca2+ levels.
Noboru Yata, Kiyoshi Sakai, Miyuki Fukui, Ayumi Tsutsumi, Toshiaki Nishihata   +4 more
core   +1 more source

Metabolomic identification of predictive and early biomarkers of cisplatin‐induced acute kidney injury in adult head and neck cancer patients

British Journal of Clinical Pharmacology, Volume 90, Issue 8, Page 1790-1803, August 2024.
Aim Cisplatin causes acute kidney injury (AKI) in approximately one third of patients. Serum creatinine and urinary output are poor markers of cisplatin‐induced AKI. Metabolomics was utilized to identify predictive or early diagnostic biomarkers of cisplatin‐induced AKI.
Yong Jin Lim, Steven G. Xiu, M. Sara Kuruvilla, Eric Winquist, Stephen Welch, Morgan Black, Lauren N. Faught, Jasmine Lee, Michael J. Rieder, Tom D. Blydt‐Hansen, Michael Zappitelli, Bradley L. Urquhart   +11 more
wiley   +1 more source

The Effects of Chlorpropamide in Diets of Gravid Gilts on Embryo Survival, Fetal Weight and Fetal and Dam Blood Sugar Levels [PDF]

, 1972
Seventy-six primiparous, crossbred gilts averaging approximately 125 to 135 kg were used in a series of two experiments to determine the effects of chlorpropamide upon reproductive and blood criteria.
Wachholz, Duane E.
core   +1 more source