Results 51 to 60 of about 3,073 (184)

Medications and Acute Hemolysis in G6PD‐Deficient Patients – A Real‐World Study

Clinical Pharmacology &Therapeutics, Volume 116, Issue 6, Page 1537-1543, December 2024.
Many drug labels contain precautions of use in G6PD‐deficient patients due to hemolytic concerns, but much of this is based on scarce clinical, epidemiological, or structural data. In this real‐world study, we aimed to examine if the administration of presumably risky medications for G6PD‐deficient patients was followed by hemolysis. The study is based
Naomi Gronich, Bar Rosh, Nili Stein, Walid Saliba   +3 more
wiley   +1 more source

Chlorpropamide Inhibition Of Excision Repair And Postreplication Repair Of Ultraviolet Damage In Chinese Hamster Ovary Cells

, 1980
Chlorpropamide, an oral hypoglycemic agent, was tested for effects on excision repair and postreplication repair of ultraviolet (UV) damage of DNA in CHO-K1 cells. The technique used to measure excision repair involved isopycnic centrifugation of density-
Brown, Roger F.
core   +1 more source

Glyburide use is associated with a greater likelihood of mortality or rehospitalization after acute coronary syndrome compared to gliclazide use in adults with type 2 diabetes: A cohort study

Diabetes, Obesity and Metabolism, Volume 26, Issue 11, Page 5408-5419, November 2024.
Abstract Aim To examine the likelihood of mortality or rehospitalization following acute coronary syndrome with glyburide versus gliclazide use in adults with type 2 diabetes undergoing cardiac catheterization. Research Design and Methods This retrospective cohort study used clinical data linked with administrative health data from Alberta, Canada ...
Wentong Long, Peter E. Light, Scot H. Simpson   +2 more
wiley   +1 more source

HPLC Determination of Chlorpropamide in Human Serum by Fluorogenic Derivatization Based on the Suzuki Coupling Reaction with Phenylboronic Acid

, 2013
A fluorogenic derivatization method for the determination of chlorpropamide in human serum was developed by means of high-performance liquid chromatography (HPLC) with fluorescence detection.
Hammad, Sherin Farouk, Kubo, Kimiko, Kuroda, Naotaka, Mabrouk, Mokhtar Mohamed, Ohyama, Kaname, Nakashima, Kenichiro, Kishikawa, Naoya   +6 more
core   +1 more source

Metabolomic identification of predictive and early biomarkers of cisplatin‐induced acute kidney injury in adult head and neck cancer patients

British Journal of Clinical Pharmacology, Volume 90, Issue 8, Page 1790-1803, August 2024.
Aim Cisplatin causes acute kidney injury (AKI) in approximately one third of patients. Serum creatinine and urinary output are poor markers of cisplatin‐induced AKI. Metabolomics was utilized to identify predictive or early diagnostic biomarkers of cisplatin‐induced AKI.
Yong Jin Lim, Steven G. Xiu, M. Sara Kuruvilla, Eric Winquist, Stephen Welch, Morgan Black, Lauren N. Faught, Jasmine Lee, Michael J. Rieder, Tom D. Blydt‐Hansen, Michael Zappitelli, Bradley L. Urquhart   +11 more
wiley   +1 more source

The effect of composition and ageing on the dissolution rates of chlorpropamide-urea solid dispersions

, 1977
Discs of chlorpropamide and urea have been prepared by (a) melting and (b) compression. Intrinsic and relative dissolution rates of the discs have been measured and the dissolution process investigated microscopically. Higher dissolution rates were found
James L Ford, Michael H Rubinstein
core   +1 more source

Current type 2 diabetes guidelines: Individualized treatment and how to make the most of metformin

Diabetes, Obesity and Metabolism, Volume 26, Issue S3, Page 55-74, August 2024.
Abstract Evidence‐based guidelines provide the premise for the delivery of quality care to preserve health and prevent disabilities and premature death. The systematic gathering of observational, mechanistic and experimental data contributes to the hierarchy of evidence used to guide clinical practice. In the field of diabetes, metformin was discovered
Juliana C. N. Chan, Aimin Yang, Natural Chu, Elaine Chow   +3 more
wiley   +1 more source

Prevalence of potentially inappropriate medications among newly treated patients with type 2 diabetes in UK primary care

British Journal of Clinical Pharmacology, Volume 90, Issue 6, Page 1376-1394, June 2024.
Abstract Aims The aim of this study was to estimate the prevalence of potentially inappropriate prescriptions (PIPs) in patients starting their first noninsulin antidiabetic treatment (NIAD) using two explicit process measures of the appropriateness of prescribing in UK primary care, stratified by age and polypharmacy status.
Maria Luisa Faquetti, Géraldine Frey, Dominik Stämpfli, Stefan Weiler, Andrea M. Burden   +4 more
wiley   +1 more source

Amounts of chlorpropamide, glibenclamide, gliclazide, glimepiride, metformin, nateglinide, pioglitazone, rosiglitazone, and vildagliptin in plasma of volunteers (n = 16).

, 2016
Amounts of chlorpropamide, glibenclamide, gliclazide, glimepiride, metformin, nateglinide, pioglitazone, rosiglitazone, and vildagliptin in plasma of volunteers (n = 16).
Thais Martins Guimarães de Francisco (700514), Roberto Pontarolo (354531), Letícia Bonancio Cerqueira (3387200), Mariana Millan Fachi (3387206), Letícia Paula Leonart (3387203)   +4 more
core   +1 more source

Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State

ChemistrySelect, Volume 9, Issue 11, March 18, 2024.
This study investigates the use of aqueous eutectic mixtures to enhance the solubility of carvedilol, a drug with low solubility and bioavailability. It was found that mixtures of citric acid and choline chloride increased the maximum solubility. Additionally, the stability of carvedilol in these mixtures was demonstrated.
Laura Lomba, Alejandra Polo, Nuria Martínez, Julia Alejandre, Beatriz Giner   +4 more
wiley   +1 more source