Results 1 to 10 of about 308 (140)

In vitro Antimicrobial Activity of Chlorquinaldol against Microorganisms Responsible for Skin and Soft Tissue Infections: Comparative Evaluation with Gentamicin and Fusidic Acid [PDF]

Frontiers in Microbiology, 2017
Skin and soft tissue infections (SSTIs) are a major therapeutic challenge for clinicians. The emergence of pathogens with decreased susceptibility to available therapies has become an emerging problem often associated with treatment failure. Hence, there
Alessandro Bidossi, Elena De Vecchi, Lorenzo Drago   +2 more
exaly   +12 more sources

Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase [PDF]

ACS Central Science
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with limited treatment options. Thus, it is essential to investigate potential druggable targets to improve IPF treatment outcomes. By screening a curated library of 201 small molecules, we have identified chlorquinaldol, a known antimicrobial drug, as a potential ...
Zhongjin Yang, Ping Sun, Wenhui Hu
exaly   +5 more sources

Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases [PDF]

Molecular Medicine
Background NLRP3 inflammasome immoderate activation results in the occurrence of various inflammatory diseases, but the clinic medications targeting NLRP3 inflammasome are still not available currently.
Zhilei Wang, Jingwen Liu, Yu Mou, Yuchen Li, Wenhao Liao, Menglin Yao, Ting Wang, Hongping Shen, Qin Sun, Jianyuan Tang   +9 more
doaj   +4 more sources

Chlorquinaldol, a topical agent for skin and wound infections: anti-biofilm activity and biofilm-related antimicrobial cross-resistance [PDF]

Infection and Drug Resistance, 2019
Alessandro Bidossi,1 Marta Bottagisio,1 Roberta De Grandi,1 Lorenzo Drago,2 Elena De Vecchi11Laboratory of Clinical Chemistry and Microbiology, IRCCS Orthopedic Institute Galeazzi, Milan, Italy; 2Laboratory of Clinical Microbiology, Department of ...
Bidossi A, Bottagisio M, De Grandi R, Drago L, De Vecchi E   +4 more
doaj   +4 more sources

Insight into the Mode of Action of 8-Hydroxyquinoline-Based Blockers on the Histamine Receptor 2 [PDF]

Biosensors, 2023
Histamine receptor 2 (HRH2) blockers are used to treat peptic ulcers and gastric reflux. Chlorquinaldol and chloroxine, which contain an 8-hydroxyquinoline (8HQ) core, have recently been identified as blocking HRH2.
Amisha Patel, Paola L. Marquez-Gomez, Lily R. Torp, Lily Gao, Pamela Peralta-Yahya   +4 more
doaj   +2 more sources

Evidence on the therapeutic role of thiolutin in imiquimod-induced psoriasis-like skin inflammation in mice. [PDF]

Immun Inflamm Dis, 2023
Studies speculated that NLRP3 inflammasome has a role in the pathogenesis of IMQ‐induced psoriasis‐like lesions in mice, and THL may alleviate psoriasis‐like manifestations in mice by inhibiting NLRP3 inflammasome. The study herein provides a new drug candidate for the treatment of psoriasiform skin inflammation, and sheds new light on the subsequent ...
Wang A, Ma X, Wei F, Li Y, Liu Q, Zhang H.   +5 more
europepmc   +2 more sources

Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation. [PDF]

Clin Transl Med, 2023
DUXAP8 mediated activation of SLC7A11 restrained the sensitivity of HCC to sorafenib induced ferroptosis. DUXAP8 facilitated the previously unknown palmitoylation of SLC7A11 and prevented SLC7A11 lysosomal degradation. Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in HCC.
Shi Z, Li Z, Jin B, Ye W, Wang L, Zhang S, Zheng J, Lin Z, Chen B, Liu F, Zhang B, Ding X, Yang Z, Shan Y, Yu Z, Wang Y, Chen J, Chen Q, Roberts LR, Chen G.   +19 more
europepmc   +2 more sources

GPA Peptide-Induced Nur77 Localization at Mitochondria Inhibits Inflammation and Oxidative Stress through Activating Autophagy in the Intestine. [PDF]

Oxid Med Cell Longev, 2020
Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disease affecting the colon, and its incidence is rising worldwide. Nur77, belongs to the NR4A subfamily of nuclear hormone receptors, plays a critical role in controlling the pathology of colitis.
Deng Z, Liu Q, Wang M, Wei HK, Wei HK, Peng J.   +5 more
europepmc   +2 more sources

GSH-Responsive Nano-Photosensitizer for Potentiating Photodynamic Therapy Through Multi-Pronged Synergistic Upregulation of Ferroptosis Sensitivity [PDF]

Antioxidants
Impeded by the limited light penetration of photodynamic therapy (PDT) to tissues and the hypoxic environment of solid tumors, the clinical therapeutic efficacy and application are below expectations.
Yunong Ma, Kexin Xu, Jing Feng, Xi Zhao, Peilin Tian, Jiayang Luo, Luyao Xu, Jiaxing Song, Cuixia Lu   +8 more
doaj   +2 more sources

Identification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library [PDF]

Pathogens, 2017
Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant threat for effective treatment of several difficult-to-treat infections in humans.
Hongxia Niu, Rebecca Yee, Peng Cui, Lili Tian, Shuo Zhang, Wanliang Shi, David Sullivan, Bingdong Zhu, Wenhong Zhang, Ying Zhang   +9 more
doaj   +2 more sources