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Section 10: Cardiovascular Disease and Risk Management. [PDF]

Clin Diabetes
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Understanding the BP-Lowering Mechanism of Chlorthalidone in Advanced Kidney Disease.

Clin J Am Soc Nephrol
Jafar TH, Feng L.
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Chlorthalidone Versus Hydrochlorothiazide

Annals of Internal Medicine, 2013
TO THE EDITOR: Dhalla and colleagues state, "As typically prescribed, chlorthalidone in older adults was not associated with fewer adverse cardiovascular events or deaths than hydrochlorothiazide. However, it was associated with a greater incidence of electrolyte abnormalities, particularly hypokalemia." This observational cohort study is contrary to a
DiNicolantonio, James J., O'Keefe, James H., Lavie, Carl J.   +2 more
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Chlorthalidone: The Forgotten Diuretic

Postgraduate Medicine, 2012
Chlorthalidone's safety and efficacy in the management of hypertension has been demonstrated in landmark trials. Despite understanding the effects of thiazides on urinary sodium excretion and intravascular volume, the exact mechanism of their antihypertensive effects is not clearly understood. Common compensatory mechanisms for decreases in circulating
David S, Kountz, Andrew, Goldman, John, Mikhail, Mayer, Ezer   +3 more
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Automated Analysis of Chlorthalidone

Journal of Pharmaceutical Sciences, 1979
Chlorthalidone inhibition of the enzymatic hydrolysis rate of p-nitrophenyl acetate by bovine erythrocyte carbonic anhydrase was used as a basis for chlorthalidone determination in plasma and urine. For urinary samples, a completely automated, continuous flow system was developed to extract the samples and perform the enzymatic reaction.
M M, Johnston, M, Rosenberg, B, Kamath
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Chlorthalidone-Induced Hypercalcemia

JAMA: The Journal of the American Medical Association, 1975
To the Editor.— In the July 15 issue ofThe Journal(229:267, 1974), Palmer described a patient with hypercalcemia, presumedly secondary to chlorthalidone (Hygroton) administration. Previous reports have shown that thiazides and chlorthalidone can cause permanent hypercalcemia in patients with hyperparathyroidism.
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Incidence of Chlorthalidone-Induced Hypercalcemia

JAMA, 1978
To the Editor.— In 1974 a case of hypercalcemia secondary to the administration of chlorthalidone was reported (229:267, 1974). At that time the frequency of this phenomenon was unknown. To answer this question, 39 consecutive patients with untreated hypertension were placed on chlorthalidone therapy, 50 mg/ day.
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Probable chlorthalidone-induced hypokalemic rhabdomyolysis

Journal of the American Pharmacists Association
A case of hypokalemic rhabdomyolysis related to chlorthalidone use is reported CASE SUMMARY: A 52-year-old male was admitted to the hospital for acute onset generalized weakness and was found to have severe hypokalemia and rhabdomyolysis. The patient had been on chlorthalidone therapy with a dose increase from 25 mg daily to 50 mg daily 2 months prior ...
Gagandeep Singh, Caitlin Canton, Diana R. Langworthy   +2 more
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