Results 131 to 140 of about 331,698 (221)

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

Advanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du, Akiko Mizokami, Junjun Ni, Simeng Zhang, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Isei Tanida, Takashi Kanematsu   +8 more
wiley   +1 more source

Ionic liquid-iontophoresis mediates transdermal delivery of sparingly soluble drugs. [PDF]

Drug Deliv
Gao W, Xing W, Tang Z, Wang Q, Yu W, Zhang Q.   +5 more
europepmc   +1 more source

Serrated Leaf‐Like N‐Doped Copper Sulfide Enabling Bifunctional Oxygen Reduction/Evolution via Dual‐Mode Cathode Reactions for High Energy Density and Cycle Stability in Zinc–Air Batteries

Advanced Science, EarlyView.
A serrated leaf‐like nitrogen‐doped copper sulfide (N‐CuS) cathode with hybridized N 2p – S 3p orbitals is presented, mesopores for oxygen transport, and a five times larger electrochemical active surface area than Cu. In aerobic conditions, a zinc–air battery with N‐CuS achieves 788 mAh g⁻¹ and 916 Wh kg⁻¹, outperforming Pt/C+RuO₂.
Do Hwan Jung, Yong Hak Park, Dong Won Kim, Jong Hui Choi, Seungrae Cho, Keon‐Han Kim, Dong Gyu Park, Byungchan Han, Jeung Ku Kang   +8 more
wiley   +1 more source

Elite collegiate swimmers do not meet sport nutrition recommendations during heavy training: effects of sex and within-day nutrient timing. [PDF]

J Int Soc Sports Nutr
Lundstrom EA, De Souza MJ, Khen KM, Williams NI.   +3 more
europepmc   +1 more source

Ultrasound‐Assisted H2 Transmitter Enables Hydrogen‐Gene Therapy to Prevent Anesthesia/Surgery‐Induced Cognitive Impairment

Advanced Science, EarlyView.
Postoperative cognitive dysfunction (POCD) remains a challenge with no effective treatments. This study introduces a novel hydrogen‐gene therapy strategy, combining focused ultrasound and siRNA delivery via hydrogen emitters, to repair neuroinflammation in a precise and controlled manner.
Ruonan Zhan, Yan Fang, Chuyun Lou, Nan Chen, Xuan Mo, Bo Jiao, Mengke Liu, Yangxi Zhao, Weichen Xu, Huixiong Xu, Haohao Yin, Yi Zhang   +11 more
wiley   +1 more source

TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism

Advanced Science, EarlyView.
TRIM25‐mediated ubiquitination of INSIG1 serves as a key driver of lipid metabolism dysregulation in MASH progression. It identifies a novel small‐molecule inhibitor, C27H26N2O4S, which effectively inhibits TRIM25 activity, reducing lipid accumulation and inflammation.
Hao Zhang, Xiangxu Kong, Wei Wang, Huaxin Zhou, Haoran Qu, Zhengyao Guan, Honglei Wu, Xiangyu Zhai, Bin Jin   +8 more
wiley   +1 more source

Magnetic resonance spectroscopy for enhanced multiparametric MRI characterization of [¹⁸F]FET PET-negative gliomas. [PDF]

EJNMMI Res
Li X, Xiao X, Han X, Cheng Y, Cui B, Zhang M, Liu H, Lu J.   +7 more
europepmc   +1 more source

Minimizing Energy Loss by Designing Multifunctional Solid Additives to Independent Regulation of Donor and Acceptor Layers for Efficient LBL Polymer Solar Cells

Advanced Science, EarlyView.
The simultaneous incorporation of multifunctional solid additives into both D18 and L8‐BO layers can not only effectively enhance the crystallinity and molecular stacking of D18, but also form an appropriate phase separation morphology, which will reduce ΔE2 and ΔE3 and achieve an excellent power conversion efficiency of 19.95% in layer‐by‐layer ...
Junying Wang, Min Deng, Haonan Chen, Wuke Qiu, Yuwei Duan, Chentong Liao, Ruipeng Li, Liyang Yu, Qiang Peng   +8 more
wiley   +1 more source

Fantastic genes and where to find them expressed in CHO. [PDF]

Comput Struct Biotechnol J
Riedl M, Ruggeri C, Marx N, Borth N.
europepmc   +1 more source

Multiple bioactivities of choerospondin obtained from blossom of Citrus aurantium L. Var. Amara engl. And its anti-inflammation and anti-atherosclerosis action pathways

Journal of Functional Foods
Nutritional intervention has been emerged as a popular strategy to improve quality of human life. Here we extracted and identified choerospondin (CHO), a dietary flavonoid glycoside from blossom of Citrus aurantium L. var. amara Engl.
Ke-Xin Hao, Chun-Yan Shen, Rui-Fang Zhong, Jian-Guo Jiang   +3 more
doaj