Results 121 to 130 of about 4,711,608 (247)
Applied Microbiology and BiotechnologyAbstract Histone methylation–mediated epigenetic modification significantly influences gene transcription and expression regulation. This study examined the effects of histone 3 lysine 9 trimethylation (H3K9me3) methyltransferase SUV39H1 and its specific
Lu-Lu Yang +9 more
doaj +1 more source
Giant Bulk Photovoltaic Effect in Two‐Dimensional Topological Ferroelectric Semimetal
Advanced Science, EarlyView.ABSTRACT Ferroelectric (FE) metals have attracted growing interest because they combine ferroelectricity with metallic behavior and enable polarization‐controlled band topology near the Fermi level. However, the number of known ferroelectric metals is still limited.
Jianhua Wang +8 more
wiley +1 more source
Advanced Science, EarlyView.Sinapic acid, a bio‐derived phytophenol, serves as a multifunctional additive for methylammonium (MA)‐free Sn─Pb perovskites, coordinating with Sn2+/Pb2+ to regulate crystallization and mitigate defects. Its electron‐rich groups suppress Sn oxidation and passivate deep traps, improving band alignment and reducing VOC losses. Resulting devices achieve a
Seojun Lee +12 more
wiley +1 more source
Биопрепараты: Профилактика, диагностика, лечение, 2018 Perfusion cultivation process for CHO cells producing recombinant B-domen deleted coagulation factor VIII was developed. Cell culture medium and feed supplement were optimized by screening of big panel of prototype media and supplements.
A. N. Morozov +4 more
doaj
Sliding Ferroelectricity Driven Spin‐Layertronics in Altermagnetic Multilayers
Advanced Science, EarlyView.Integrating sliding ferroelectricity with altermagnetism enables nonvolatile electrical control of spin and layer degrees of freedom. In bilayer CuF2, interlayer translation reverses layer‐locked spin‐split bands, establishing a multifunctional “spin‐layertronic” platform.
Rui Peng +5 more
wiley +1 more source
Advanced Science, EarlyView.A rational architectural design of hierarchical, CNT‐interwoven hollow carbon microclusters unlocks and stabilizes a unique monoclinic Co3Se4‐mediated conversion–insertion pathway for potassium storage. This structural confinement effectively guides the reaction kinetics and accommodates severe mechanical strain.
Ho Rim Kim +8 more
wiley +1 more source
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
Bipolar Palladium Membrane Enabling Crossover‐Free Selective Proton Transport
Advanced Science, EarlyView.This study introduces a crossover‐free bipolar palladium membrane that transports protons selectively via reversible Pd/PdHx absorption–desorption and lattice hydrogen diffusion, overcoming the conductivity–selectivity trade‐off of polymer membranes. It enables water‐fed Li‐mediated ammonia synthesis, achieving 51% Faradaic efficiency and stable 12 h ...
Jiyeon Baek +11 more
wiley +1 more source
Advanced Science, EarlyView.USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen +7 more
wiley +1 more source