Results 111 to 120 of about 228,451 (311)
Advanced Healthcare Materials, EarlyView.A multivalent DNA nanostructure‐enabled lateral flow assay was developed for rapid, ultrasensitive detection of porcine epidemic diarrhea virus (PEDV) nucleocapsid protein. Designer net‐shaped DNA nanostructures (DNA‐Net) presenting PEDV‐specific aptamers achieved ~1000‐fold enhanced binding, enabling detection of viral copies with Ct ≤ 37.42 within 10
Saurabh Umrao +9 more
wiley +1 more source
The effects of both noradrenaline and CGP12177, mediated through human beta(1)-adrenoceptors, are reduced by PDE3 in human atrium but PDE4 in CHO cells [PDF]
, 2007 (-)-Noradrenaline and (-)-CGP12177 activate beta(1)-adrenoceptors through a high (H)- and low-affinity (L) site, respectively. The positive inotropic effects of (-)-noradrenaline are blunted by phosphodiesterase4 (PDE4) but not PDE3, while both PDE ...
Semmler, Annalese +3 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang +17 more
wiley +1 more source
Cholesterol level was higher in the CHO PS1 ΔE9 cells than in the PS1 WT cells. [PDF]
, 2019 (a) Free cholesterol was visualized by filipin staining from the CHO PS1 WT and ΔE9 cells. (b) Fluorescence intensities were compared between the PS1 WT (n = 11) and ΔE9 cells (n = 13).
Sungkwon Chung (71502) +4 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He +9 more
wiley +1 more source
Hyaluronan reduces migration and proliferation in CHO cells
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2001 Expression of the hyaluronan synthase gene in hyaluronan-deficient CHO cells changed the cell morphology from a spindle shape to a flattened epithelial-type form. Hyaluronan producing CHO cells showed reduced initial cell adhesion, migration, proliferation and density at contact inhibition, but no difference in random migration determined by the Boyden
Dübe, Birgit +3 more
openaire +2 more sources
Plasmonic Enhancement of Fluorescence and Protein Dynamics in Living Mammalian Cells
Advanced Materials, EarlyView.This study demonstrates plasmonic enhancement of the function of fluorescent voltage sensing proteins (genetically encoded voltage indicators, (GEVIs), QuasAr6) in live mammalian cells. Coupling to plasmonic nanoparticles does not just increase fluorescence, but influences the protein photocycle, creating a hybrid sensor with its response speed to ...
Marco Locarno +16 more
wiley +1 more source
Ferroelectric Quantum Dots for Retinomorphic In‐Sensor Computing
Advanced Materials, EarlyView.This work has provided a protocol for fabricating retinomorphic phototransistors by integrating ferroelectric ligands with quantum dots. The resulting device combines ferroelectricity, optical responsiveness, and low‐power operation to enable adaptive signal amplification and high recognition accuracy under low‐light conditions, while supporting ...
Tingyu Long +26 more
wiley +1 more source
High throughput, efficacious gene editing & genome surveillance in Chinese hamster ovary cells.
PLoS ONE, 2019 Chinese hamster ovary (CHO) cells are a common tool utilized in bioproduction and directed genome engineering of CHO cells is of great interest to enhance recombinant cell lines.
S C Huhn, Y Ou, A Kumar, R Liu, Z Du
doaj +1 more source
Binding of immune serum IgG to recombinant wild-type GPCRs expressed in CHO cells. [PDF]
, 2013 The ability of immune serum IgG from mice immunized against hNPFFR2 (upper panels), hKOR (middle panels) and hMOR (lower panels) to specifically bind to their corresponding receptors (i.e.
Lionel Moulédous (305345) +4 more
core +1 more source