Results 91 to 100 of about 12,852,402 (297)
Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges
Advanced Functional Materials, EarlyView.Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley +1 more source
Advanced Functional Materials, EarlyView.We propose a suture‐complementary approach that integrates optical skin clearing with a strain‐programmable luminescent adhesive patch. Hyaluronic acid promotes transdermal delivery of tartrazine to improve optical clearing and stabilizes its interaction with a photosensitizer. Optical clearing increases the penetration depth of visible light into skin,
Seong‐Jong Kim +6 more
wiley +1 more source
Network reconstruction of the mouse secretory pathway applied on CHO cell transcriptome data [PDF]
, 2017 BACKGROUND: Protein secretion is one of the most important processes in eukaryotes. It is based on a highly complex machinery involving numerous proteins in several cellular compartments.
Andersen, Mikael Rørdam +6 more
core +3 more sources
Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells
mAbs, 2015 Linking the heavy chain (HC) and light chain (LC) genes required for monoclonal antibodies (mAb) production on a single cassette using 2A peptides allows control of LC and HC ratio and reduces non-expressing cells.
Jake Chng +8 more
semanticscholar +1 more source
Molecular and functional characteristics of seven-transmembrane-domain receptor APJ [PDF]
, 2001 APJ is a member of seven-transmembrane-domain receptors, but its ligand had not been identified for a long time. I prepared CHO cells expressing APJ (CHO-A10 cells), and searched for the endogenous ligand for APJ by monitoring specific signal ...
Hosoya Masaki, 細谷 昌樹
core
Production of α2,6-sialylated IgG1 in CHO cells
mAbs, 2015 The presence of α2,6-sialic acids on the Fc N-glycan provides anti-inflammatory properties to the IgGs through a mechanism that remains unclear. Fc-sialylated IgGs are rare in humans as well as in industrial host cell lines such as Chinese hamster ovary (
C. Raymond +5 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Bioprosthetic aortic valves have revolutionized the treatment of aortic stenosis, but their durability is limited by structural valve deterioration (SVD). This review focuses on the pericardial tissue at the heart of these valves, examining how its mechanical properties and calcification drive fatigue and failure.
Gabriele Greco +7 more
wiley +1 more source
CellsThe complex structure of monoclonal antibodies (mAbs) expressed in Chinese hamster ovary (CHO) cells may result in the accumulation of unfolded proteins, triggering endoplasmic reticulum (ER) stress and an unfolded protein response (UPR).
Chen Zhang +7 more
doaj +1 more source
PD-1 blockade augments anti-neuroblastoma immune response induced by anti-GD2 antibody ch14.18/CHO
OncoImmunology, 2017 Immunotherapy with anti-GD2 antibody (Ab) ch14.18/CHO is effective for treatment of high-risk neuroblastoma (NB) patients and is mainly based on GD2-specific Ab-dependent cellular cytotoxicity (ADCC).
Nikolai Siebert +4 more
doaj +1 more source
Frontiers in Physiology, 2016 Microcystin-LR (MC-LR) is a ubiquitous peptide that exhibits strong reproductive toxicity, although the mechanistic basis for such toxicity remains largely unknown.
Shenshen Zhang +7 more
doaj +1 more source