Molecular recombination and the repair of DNA double-strand breaks in CHO cells [PDF]
Michael A. Resnick, Peter D. Moore
openalex +1 more source
This study demonstrates a molecular strategy to enhance the stretchability of conjugated polymers by incorporating plasticizing molecular additives (PMAs). PMAs reduce the persistence length and promote chain entanglement, enabling deformable thin films with preserved electrical performance. A systematic analysis combining rheology, neutron scattering,
Sein Chung+11 more
wiley +1 more source
RNA methylation and control of eukaryotic RNA biosynthesis: processing and utilization of undermethylated tRNAs in CHO cells [PDF]
François Amalric+2 more
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Dimensions of the Ascending and Descending Sets in Complex Stratified Morse Theory [PDF]
We present a new construction of gradient-like vector fields in the setting of Morse theory on a complex analytic stratification. We prove that the ascending and descending sets for these vector fields possess cell decompositions satisfying the dimension bounds conjectured by M. Goresky and R. MacPherson. Similar results by C.-H. Cho and G.
arxiv
Glucocorticoids Alter Bone Microvascular Barrier via MAPK/Connexin43 Mechanisms
Osteoporosis induced by Glucocorticoids (GCs) is a common complication of long‐term GC use in patients with inflammatory and autoimmune conditions, often leading to an increased fracture risk. A 3D bicellular endo‐osteo microfluidic platform is developed to explore pathogenic mechanisms underlying GCs‐induced osteoporosis, highlighting a novel MAPK ...
Eun‐Jin Lee+10 more
wiley +1 more source
Re-engineering of CHO cells using genome editing and the overexpression of multiple helper genes is the central track for obtaining better cell lines for the production of biopharmaceuticals.
Nadezhda Alexandrovna Orlova+5 more
doaj +1 more source
Multiple glycerol shocks increase the calcium phosphate transfection of non-synchronized CHO cells [PDF]
The exposure of CHO DG44 cells to an osmotic shock, after DNA uptake, results in a cellular volume decrease of approx. 55%. Repetitive osmotic shocks targeted different sub-populations of cells as was demonstrated using two different fluorescent reporter
Bertschinger, Martin+3 more
core
SYNCHRONIZATION OF MITOCHONDRIAL DNA SYNTHESIS IN CHINESE HAMSTER CELLS (LINE CHO) DEPRIVED OF ISOLEUCINE [PDF]
Kenneth D. Ley, Marilyn M. Murphy
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An Enrichment Method for Obtaining Biologically Significant Genes from Statistically Significant Differentially Expressed Genes in Comparative Transcriptomics [PDF]
Cells coordinate adjustments in genome expression to accommodate changes in their environment. A drug in culture media for in vitro preclinical testing sometimes cause drastic regime shifting of genome expression system depending on the concentrations; e.g.
arxiv
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto+2 more
wiley +1 more source