Results 191 to 200 of about 644,201 (301)

Hybrid modeling for optimizing cell cultivation in mAb production using a small‐scale automated experimental platform

AIChE Journal, EarlyView.
Abstract This work presents the optimization of cell cultivation for monoclonal antibody (mAb) production. We developed a hybrid model describing the effects of multiple process variables on antibody productivity and impurity generation. An automated platform with 12 × 250 mL bioreactors was set up.
Kosuke Nemoto, Yuki Yoshiyama, Mizuki Morisasa, Junshin Iwabuchi, Yusuke Hayashi, Sara Badr, Hirokazu Sugiyama   +6 more
wiley   +1 more source

Proactive Robotic Grasp Stability via Tactile Safety Margin Feedback

Advanced Intelligent Systems, EarlyView.
We introduce the tactile safety margin (TSM), defined as the ratio between applied friction force (Ffric) and maximum friction (Fmax) derived from grip force. A bilayer E‐skin with decoupled temperature, strain, and pressure sensing enables real‐time grasp stability monitoring through measured TSM values, allowing robots to proactively adjust grip ...
Yebin Park, Jaehyun Kim, Taeyeong Kim, Woosung Cho, Junchen Luo, Myeongryun Seong, Chaeyong Park, Anna Lee, Seungmoon Choi, Insang You, Unyong Jeong   +10 more
wiley   +1 more source

Production of Recombinant S1 Protein of Porcine Epidemic Diarrhea Virus in Recombinant CHO Cells for Application in Indirect ELISA. [PDF]

J Microbiol Biotechnol
Lee EJ, Kim S, Kim TH, Heo NY, Kim HS, Ryu SH, Koo SJ, Won H, Kim YG.   +8 more
europepmc   +1 more source

Integrating Artificial Intelligence With Droplet‐Based Microfluidics: Advances, Challenges, and Emerging Opportunities

Advanced Intelligent Systems, EarlyView.
Droplet‐based microfluidics enables precise, high‐throughput microscale reactions but continues to face challenges in scalability, reproducibility, and data complexity. This review examines how artificial intelligence enhances droplet generation, detection, sorting, and adaptive control and discusses emerging opportunities for clinical and industrial ...
Junyan Lai, Sukrit Gaira, Rongfeng Wang, Qingtian Zhang, Ming Li, Liao Wu, Diangeng Li, Yi Li, Chengchen Zhang, Jinhong Guo, Shi‐Yang Tang   +10 more
wiley   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +2 more sources

Comprehensive genome-scale CRISPR knockout screening of CHO cells. [PDF]

Sci Data
Shin SW, Kim SH, Gasselin A, Lee GM, Lee JS.   +4 more
europepmc   +1 more source

Hidden in the Labour Market: An Intersectional Latent Class Analysis of Discouraged Workers in Australia

Australian Journal of Social Issues, EarlyView.
ABSTRACT This study employs an intersectionality‐informed latent class analysis (LCA) to examine the hidden diversity of discouraged workers in Australia. Drawing on nationally representative data from the Household, Income and Labour Dynamics in Australia Survey, we identified six empirically distinct subgroups defined by intersecting demographic and ...
Sora Lee, Woojin Kang
wiley   +1 more source

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

Angewandte Chemie, EarlyView.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara, Rio Takaiso, Shota Kawaguchi, Atsunori Oshima, Masaki Kita   +4 more
wiley   +2 more sources

Structural and Functional Characterization of Anti-SARS-CoV-2 Spike Monoclonal Antibodies Produced via Bicistronic Expression in CHO Cells. [PDF]

Antibodies (Basel)
Marsili FF, de Aquino FB, Arruda HRDS, Marques MA, Cabral KMDS, Almeida MDS, de Oliveira GAP, Maranhão AQ, Carvalho RS, Castilho LDR.   +9 more
europepmc   +1 more source

Uncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR‐F508del Rabbit Model

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder frequently associated with impaired mucociliary clearance and bacterial infection. Individuals carrying a single cystic fibrosis transmembrane conductance regulator (CFTR) mutation exhibit partial CFTR dysfunction and are increasingly recognized as being at risk ...
Do‐Yeon Cho, Alexis E. McFeely, Daniel Skinner, Shaoyan Zhang, Justin Hedvat, Weslee Ping‐ay, Daniel M. Beswick, Justin H. Turner, Bradford A. Woodworth, Jie Xu   +9 more
wiley   +1 more source