Clastogenic effects of two tyrosine kinase inhibitors, Tyrphostin 23 and Tyrphostin 46, on a transformed (CHO-K1) and on a primary embryonic Chinese hamster cell line (CHE) [PDF]
, 2000 Loredana Bassi
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Advanced Science, EarlyView.Patch‐clamp experiments are fundamental to the measurement and understanding of ion currents that underlie physiological functions from neural activity to muscle contraction. Via a mathematical model of the experimental apparatus, this article highlights how artifact effects can be as large as some reported mutation and drug effects, and enables ...
Chon Lok Lei +8 more
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Increased glycoprotein hormone yield in stably transfected CHO cells using human serum albumin signal peptide for beta-chains. [PDF]
PeerJSinegubova MV +3 more
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Stress-induced increase of monoclonal antibody production in CHO cells. [PDF]
Eng Life Sci, 2022 Schellenberg J +6 more
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CHO Cell Antibody Drug Production
Therapeutic antibodies are highly regarded for their high affinity, specificity, low immunogenicity, and ability to target a wide range of biological molecules. Currently, mammalian cells, including Sp2/0, NS0, HEK293, and CHO cells, are primarily used for the production of therapeutic antibodies, with CHO cells accounting for over 70% of the ...
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Advanced Microfluidics for Single Cell‐Based Cancer Research
Advanced Science, EarlyView.Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro +10 more
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A novel dual-epigenetic inhibitor enhances recombinant monoclonal antibody expression in CHO cells. [PDF]
Appl Microbiol BiotechnolHan MM +9 more
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High-efficiency and multilocus targeted integration in CHO cells using CRISPR-mediated donor nicking and DNA repair inhibitors. [PDF]
Biotechnol Bioeng, 2023 Hamaker NK, Lee KH.
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Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation. [PDF]
, 2000 Martin Fussenegger +6 more
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