Results 141 to 150 of about 1,108,283 (319)

Patatin‐domain‐containing (phospho)lipases under control: Mammalian co‐regulators and pathogenic activation mechanisms

open access: yesFEBS Open Bio, EarlyView.
Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey   +2 more
wiley   +1 more source

Navigating the university minor choice: search strategies and the role of choice architecture

open access: yesDiscover Education
Academic trajectory building involves navigating a vast information space to identify potential future pathways. While research on choosing university minors often focuses on the final selection or completed trajectories, the exploration stage is ...
Ksenia Tenisheva   +3 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

open access: yesAging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

open access: yesAging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu   +8 more
wiley   +1 more source

ARCHITECTURE OF CHOICE – ADVICES OF BEHAVIORAL ECONOMICS

open access: yesJournal of Economic Development, Environment and People, 2017
THE NEW BOOK BY PROFESSOR DIMITAR KANEV  A book review by Venelin Terziev  Dimitar Kanev is professor and doctor of economic sciences. He is one of the known and established Bulgarian scientists, whose major interests are connected with the general ...
Venelin Terziev
doaj  

Varying Neighbourhood “Choice Architecture”

open access: yesA+BE: Architecture and the Built Environment, 2015
When evaluating the factors of urban form that contribute to emissions, we must also consider the difficult but critical subject of human behaviour and choices of consumption. There is indeed a body of research findings that gives us guidance on the “choice architecture” of neighbourhood design.
openaire   +1 more source

Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong   +7 more
wiley   +1 more source

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