Results 91 to 100 of about 604,059 (242)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Patients’ Preferences for the Treatment of a Single Missing Tooth in China: A Discrete Choice Experiment

Patient Preference and Adherence
Ming-yu Zhao,1,* Wen Zeng,2,* Sze Ngai Chan,3 Jianhao Du,4 Naman Rao,5 Taoran Liu,6 Wai-kit Ming6 1Department of Prosthodontics, State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine ...
Zhao MY, Zeng W, Chan SN, Du J, Rao N, Liu T, Ming WK   +6 more
doaj  

The Mediator Role of Attitudes in Fish Choice Behavior: A Turkish Market Survey. [PDF]

Foods, 2022
Güney OI, Özşahinoğlu I, Erçen Z, Yeldan H, Dikel Ç, Sangün L.   +5 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Preference for Street Environment Based on Route Choice Behavior While Walking. [PDF]

Front Public Health, 2022
Jin L, Lu W, Sun P.
europepmc   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Individual differences in the effects of midazolam on anxiety-like behavior, learning, reward, and choice behavior in male mice. [PDF]

Front Psychiatry, 2023
Jovita-Farias C, Follett ME, Dias-Junior BC, Serra YA, Kisaki ND, Barros-Santos T, de Jesus NMS, Rodrigues IRS, Macedo LEL, Malpezzi-Marinho ELA, Oliveira-Lima AJ, Marinho EAV, Rowlett JK, Berro LF.   +13 more
europepmc   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Impact of COVID-19 on mode choice behavior: A case study for Dhaka, Bangladesh. [PDF]

Transp Res Interdiscip Perspect, 2022
Paul T, Chakraborty R, Afia Ratri S, Debnath M.   +3 more
europepmc   +1 more source