Results 191 to 200 of about 6,168,808 (307)

Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior. [PDF]

Elife
Yonk AJ, Linares-García I, Pasternak L, Juliani SE, Gradwell MA, George AJ, Margolis DJ.   +6 more
europepmc   +1 more source

The cone method: Inferring decision times from single-trial 3D movement trajectories in choice behavior. [PDF]

Behav Res Methods, 2021
Ulbrich P, Gail A.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Using recurrent neural network to estimate irreducible stochasticity in human choice behavior. [PDF]

Elife
Ger Y, Shahar M, Shahar N.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Choice childcare survey

, 2006
Long waiting lists and lack of choice over which days, the number of days and the type of childcare available were the major problems our survey respondents found when looking for childcare.

core  

Infection, Choice Behavior, and Cross-Infectivity of the Sculpted Damsel Bug, <i>Nabis roseipennis</i>, Offered the Tarnished Plant Bug, <i>Lygus lineolaris</i>, Infected with Entomopathogenic Nematodes. [PDF]

Insects
Glover JP, Spaulding N, Nufer MI, George J, Portilla M, Reddy GVP.   +5 more
europepmc   +1 more source

Remote, brain region-specific control of choice behavior with ultrasonic waves. [PDF]

Sci Adv, 2020
Kubanek J, Brown J, Ye P, Pauly KB, Moore T, Newsome W.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source