Results 121 to 130 of about 1,768,620 (297)

Effect of transcranial static magnetic stimulation over unilateral or bilateral motor association cortex on performance of simple and choice reaction time tasks. [PDF]

Front Hum Neurosci, 2023
Matsumoto T, Watanabe T, Ito K, Horinouchi T, Shibata S, Kurumadani H, Sunagawa T, Mima T, Kirimoto H.   +8 more
europepmc   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Concussion history and virtual reality metrics predict core or lower extremity injury occurrence among high school athletes

Frontiers in Sports and Active Living
IntroductionA history of concussion is recognized as a risk factor for musculoskeletal injury, which is likely associated with physiological effects that warrant better understanding. This study aimed to assess the potential of measurements obtained from
Gary B. Wilkerson, Kimberly R. Wynn, Paige W. Dill, Shellie Acocello, Lynette M. Carlson, Jennifer Hogg   +5 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Comparing the Effect of Fatigue on Choice Reaction Time of Healthy Men and Women

Physical Treatments, 2017
Purpose: Reaction time is a good indicator of coordination between sensory motion and individual performance. It is the time interval from perceiving sudden stimulus until the reaction to that stimulus.
Mahnaz Tavahomi, Sanaz Shanbehzadeh, Iraj Abdollahi   +2 more
doaj  

Effect of Choice Stepping Reaction Time (CSRT) Training using Act-React on Reaction Time and Coordination in a Parkinson’s Disease Patient: A Case Study

International Journal of Physiotherapy
Background: Parkinson’s disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, and postural instability, which contribute to delayed reaction times and poor coordination. This study aimed to evaluate
Krutee Kalpesh Sangani, Himanshu Devki Nandan Sharma, Himani Swami, Sandeep Kumar Gurjar   +3 more
doaj   +1 more source

An adaptive paradigm for detecting the individual duration of the preparatory period in the choice reaction time task. [PDF]

PLoS One, 2022
Soghoyan G, Aksiotis V, Rusinova A, Myachykov A, Tumyalis A.   +4 more
europepmc   +1 more source

Screening for Parkinson’s Disease with Response Time Barriers: A Pilot Study [PDF]

, 2004
Background: Although significant response time deficits (both reaction time and movement time) have been identified in numerous studies of patients with Parkinson’s disease (PD), few attempts have been made to evaluate the use of these measures in ...
Almeida, Quincy J., Grantier, Linda L., Jog, Mandar S., Johnson, Andrew M., Singarayer, Rene, Vernon, Philip A.   +5 more
core   +1 more source

A Toy Model for Testing Finite Element Methods to Simulate Extreme-Mass-Ratio Binary Systems

, 2006
Extreme mass ratio binary systems, binaries involving stellar mass objects orbiting massive black holes, are considered to be a primary source of gravitational radiation to be detected by the space-based interferometer LISA.
Alpert B, Arnold D N, Babuška I Strouboulis T, Bank R, Bank R, Bank R E, Bank R E, Barack L, Barack L, Barack L, Bayliss A, Bayliss A, Beijing FEGEN Software Co. Ltd, Carlos F Sopuerta, Chen L, Chen L Xu J, Ciarlet P G, Cutler C, Danzmann K, Danzmann K, Detweiler S, Dolejsi V, Drasco S, Field D A, Freitag L A Jones M T Plassmann P E, Gair J R, Hough J Rowan S Sathyaprakash B, Hughes S A, Hughes S A, Hughes T J R, Jinchao Xu, Kornhuber R, Krivan W, Lau S R, Lawson C L, Lopez-Aleman R, Lousto C O, Lousto C O, Lousto C O, Metzger J, Mino Y, Mino Y, Mino Y, Mino Y, Misner C W, Morin P, Pablo Laguna, Pengtao Sun, Poisson E, Poisson E, Prince T, Quinn T C, Rivara M C, Rivara M C, Rivara M C, Sago N, Scheel M A, Shapiro S L, Shapiro S L, Shephard M, Shoemaker D, Strang G, Tanaka T, Teukolsky S A, Vitale S, Wahlbin L B, Xu J, Zienkiewicz O C, Zienkiewicz O C, Zienkiewicz O C   +69 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source