Results 121 to 130 of about 17,265,580 (249)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Modelling departure time and mode choice [PDF]

As a result of increasing road congestion and road pricing, modelling the temporal response of travellers to transport policy interventions has rapidly emerged as a major issue in many practical transport planning studies.
Stephane Hess, Andrew Daly, John Polak, Charlene Rohr, Geoff Hyman   +4 more
core  

Reliability of computerized eye-tracking reaction time tests in non-athletes, athletes, and individuals with traumatic brain injury [PDF]

, 2018
Background: Eye tracking technologies and methodologies have advanced significantly in recent years. Specifically, the use of eye tracking to quantitatively measure oculomotor and psychophysiological constructs is gaining momentum. Reaction time has been
Lange, Belinda, Hunfalvay, Melissa, Murray, Nick, Roberts, Claire-Marie, Bolte, Takumi   +4 more
core  

Reaction time for externally-cued versus free-choice trials.

, 2019
Shows the mean reaction time across subjects for the right and left hands in externally-cued and free-choice trials. Both hands had similar reaction times which was higher for free-choice trials than for externally-cued trials.
Felix G. Contreras-Castro (8119826), Mark Hallett (192280), Nivethida Thirugnanasambandam (8119823)   +2 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Application of the Vienna Test System to Measure Training-Induced Changes in Choice Reaction Time in U20 Fencers: A 12-Week Training Program Pilot Study

Sports
This pilot study examined the effects of a 12-week reaction training program on physical and cognitive performance (choice reaction) in U20 Latvian fencers.
Lukass Edmunds Teteris, Sergejs Saulite, Renars Licis, Mara Greve, Behnam Boobani   +4 more
doaj   +1 more source