Results 141 to 150 of about 40,327 (258)

Intrahepatic bile duct strictures in a liver allograft recipient mimicking recurrent primary sclerosing cholangitis - Follow-up of a case report [PDF]

, 1991
Demetris, AJ, Gordon, R, Hartman, GG, Lerut, J, Starzl, TE   +4 more
core   +1 more source

Abcb4 Haploinsufficiency Sensitises Mice to a Diet‐Induced PSC‐Like Hepatobiliary Phenotype With Gallstone Formation

Liver International Communications, Volume 7, Issue 2, June 2026.
ABSTRACT ABCB4 translocates phospholipids (PL) into bile to buffer the toxicity of bile acids (BA) and free cholesterol (CHOL). While recessively inherited ABCB4 deficiency causes childhood Progressive Familial Intrahepatic Cholestasis type 3, haploinsufficiency has been linked to adult‐onset hepatobiliary diseases.
Eric L. Bell, Youhwa Jo, Jennifer K. Truong, Nathan O. Fuller, John P. Miller, Alastair S. Garfield, Robert O. Hughes   +6 more
wiley   +1 more source

Dye-based chromoendoscopy detects more neoplasia than white light endoscopy in patients with primary sclerosing cholangitis and IBD

Endoscopy International Open
Background and study aims Patients with primary sclerosing cholangitis and inflammatory bowel disease (IBD) have a high risk of colorectal cancer.
Rodrigo V Motta, Vipin Gupta, Karen Hartery, Paul Bassett, Simon J Leedham, Roger W Chapman, Simon PL Travis, Emma L Culver, James E. East   +8 more
doaj   +1 more source

Metformin as a Multifaceted Therapeutic Agent for Gastrointestinal Diseases: Mechanisms, Clinical Efficacy, and Future Directions

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT The high prevalence of gastrointestinal (GI) diseases and their significant impact on the quality of life require new therapeutic strategies. The development of novel therapeutic strategies should prioritize targeting the fundamental pathophysiological mechanisms underlying these diseases, including inflammation, cellular proliferation, and ...
Sayedeh Azimeh Hosseini, Hassan Valadbeigi, Seyedeh Mahdieh Khoshnazar, Saeed Khoshnood, Shahab Falahi, Delsuz Rezaee, Ali Hematian, Mohammad Hossein Haddadi   +7 more
wiley   +1 more source

Relative Exchangeable and Exchangeable Copper: Emerging New Biomarkers for Diagnosis and Therapy Monitoring in Wilson's Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Wilson's disease (WD) is a genetic disorder of copper metabolism in which early diagnosis remains challenging, particularly in acute liver failure (ALF). Relative exchangeable copper (REC) and exchangeable copper (CuEXC) are emerging biomarkers for diagnosis and monitoring, but data from larger cohorts are limited.
Sebastian Köhrer, Antoan Rusev, Holger Zimmer, Silke Wolf, Jessica Langel, Andrea Langel, Thomas Longerich, Patrick Michl, Moritz Niesert, Alexander Fichtner, Isabelle Mohr   +10 more
wiley   +1 more source

A new paradigm of the pathogenesis of primary sclerosing cholangitis associated with ulcerative colitis: microbiota and system intestine-liver. A review

Терапевтический архив
The close relationship between primary sclerosing cholangitis and ulcerative colitis has given rise to a number of hypotheses aimed at deciphering their pathogenesis from the standpoint of bidirectional connections involving immune, endocrine and ...
Evgenia S. Sbikina, Elena V. Vinnitskaya, Asfold I. Parfenov   +2 more
doaj   +1 more source

Efficacy, safety, and relapse outcomes of MAPK inhibitors in pediatric Langerhans cell histiocytosis: A real‐world study

International Journal of Cancer, Volume 158, Issue 10, Page 2674-2683, 15 May 2026.
What's new? Mitogen‐activated protein kinase (MAPK) inhibitors are promising treatments for pediatric Langerhans cell histiocytosis (LCH), a rare heterogeneous neoplasm that often affects multiple organ systems. Which MAPK inhibitors are most effective against LCH remains uncertain.
Xue Tang, Jing‐jing Sun, Zhi Wan, Xiao‐yu Jing, Xia Guo, Ju Gao   +5 more
wiley   +1 more source

Pouch Surgery for Ulcerative Colitis: Navigating Complexity in the Modern Era

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA) remains the preferred surgical treatment for patients with ulcerative colitis (UC) who require surgery but wish to avoid a permanent ileostomy. Since its introduction in 1978, IPAA has undergone continuous refinement in response to advances in both medical therapy and ...
Gabriele Bislenghi, Caroline Nordenvall, Anthony de Buck van Overstraeten, Peter Kienle, Alaa El‐Hussuna   +4 more
wiley   +1 more source

Epidemiology, Risk Factors and Pathophysiology of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease: An Update

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) represent a unique clinical syndrome affecting up to 80% of PSC patients, characterised by distinct epidemiological patterns, pathophysiological mechanisms and clinical outcomes that differ substantially from either condition occurring independently ...
Luisa Bertin, Paul Henderson, Richard Pollok, Natália Queiroz, Luca Fabris, Edoardo Vincenzo Savarino, Iago Rodríguez‐Lago, Brigida Barberio   +7 more
wiley   +1 more source

Significant kidney impairment in pediatric inflammatory bowel disease and practice points for pediatric gastroenterologists

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 5, Page 1251-1260, May 2026.
Abstract Objectives Children with inflammatory bowel disease (IBD) have an increased risk of developing kidney disorders, which may cause significant kidney function impairment (SKI) or lead to chronic kidney disease (CKD). In this study we aimed to provide insights in causes and diagnoses of SKI cases and to provide recommendations for pediatric ...
Stephanie A. Vuijk, Renz C. W. Klomberg, Tobias Schwerd, Anne M. Griffiths, Séamus Hussey, Matthew W. Carroll, Petter Malmborg, Protima Deb, Margreet Wessels, Natalia Mouratidou, Stephanie van Biervliet, Michael Friedt, Susie Minson, Femke H. M. Vrieling‐Prince, Nicholas M. Croft, Lissy de Ridder, the PIBD‐SETQuality Safety Registry Collaborative Group   +16 more
wiley   +1 more source