Results 41 to 50 of about 21,441 (140)

Incidence and Mortality Risks of Gastrointestinal Cancers During Working‐Age Period: Trends and Disparities in 204 Countries and Territories (1990–2021)

Med Research, EarlyView.
This comprehensive analysis of gastrointestinal (GI) cancer risk reveals that globally, one in 46 people will develop and one in 73 will die from GI cancers during working age (15–64 years), with 2021 incidence and mortality risks of 2.19% and 1.37%, respectively. Key findings demonstrate striking gender disparities, with males facing nearly double the
Yiming Song, Zhongge Ji, Xunbing Zhang, Qian Liang, Zeyu Li, Xiaojie Huang, Jinnan Chen, Yujie Zhou, Xinyuan Wang, Zhao Li, Liuyi Yang, Yixin Qian, Xiaolu Lin, Qingwei Zhang, Xiaobo Li   +14 more
wiley   +1 more source

Therapeutic potential of tetrahydroxylated bile acids in reducing liver injury: Insights from the Zfyve19−/− mouse model

Pediatric Investigation, EarlyView.
THBA (3α,6α,7α,12α‐Tetrahydroxy‐10β,13β‐pentanoic acid) administration can alleviate cholestatic liver injury, hepatocellular necrosis, inflammatory response, bile duct hyperplasia, and portal fibrosis in the Zfyve19−/− mouse model. This evaluation encompasses various parameters, including serum biochemistry, liver histology, immunostaining, and ...
Li Wang, Yue Yu, Jiayan Feng, Yanan Zhang, Renxue Wang, Huiyu She, Teng Liu, Victor Ling, Jianshe Wang   +8 more
wiley   +1 more source

Single‐cell RNA sequencing revealed the T‐cell heterogeneity and exhaustion subsets of Helicobacter pylori‐induced gastritis‐to‐cancer transformation

VIEW, EarlyView.
H. pylori infection is a major cause of stomach cancer, but its effect on immune cells in tumors is unclear. Using single‐cell sequencing, we mapped the stomach tumor environment and discovered a specific exhausted T‐cell subtype, marked by the FYB1 gene, that is abundant in H. pylori‐positive tumors and linked to patient prognosis. Our findings reveal
Yanhui Yang, Yanxia Liu, Xiaole Guo, Zhaorun Li, Ziyu Liu, Shuming Zhang, Yuma Yang, Jun Liu, Shoucheng Ma, Linke Ma, Xianmei Chen, Xue Li, Yuanyuan Tang, Xiaoling Ding, Xiaofei Li, Qian Hao, Yanjie You, Tingting Yang, Qingrui Li, Xue Zhang, Sihan Zhang, Hengjun Gao, Shengjuan Hu   +22 more
wiley   +1 more source

Biliary Glutathione as a Potential Marker for Viability Assessment of Cholangiocytes During Normothermic Machine Perfusion of Livers

Artificial Organs, EarlyView.
This study identifies biliary glutathione concentration during normothermic machine perfusion as a potential biomarker for biliary viability. Increasing GSH levels correlate with fewer biliary complications post‐transplant, supporting its role in assessing graft quality and improving decision‐making in liver transplantation.
Christina Bogensperger, Hannah Esser, Florian Ponholzer, Benno Cardini, Julia Hofmann, Franka Messner, Rupert Oberhuber, Thomas Resch, Dietmar Öfner, Stefan Schneeberger, Annemarie Weissenbacher   +10 more
wiley   +1 more source

High Risk of Colorectal Cancer After High‐Grade Dysplasia in Inflammatory Bowel Disease Patients

Alimentary Pharmacology &Therapeutics, EarlyView.
The advantages of colon‐sparing treatment for high‐grade dysplasia should be weighed against the higher risk of metachronous colorectal cancer and the subsequent need for stringent endoscopic surveillance. ABSTRACT Background There are limited data on colorectal cancer (CRC) risk after high‐grade dysplasia in inflammatory bowel disease.
Monica E. W. Derks, Maarten te Groen, Lauranne A. A. P. Derikx, Iris D. Nagtegaal, Frank Hoentjen   +4 more
wiley   +1 more source

Diabetes Mellitus is a Risk Factor for Hepatic Encephalopathy Following Transjugular Intrahepatic Portosystemic Shunt

Alimentary Pharmacology &Therapeutics, EarlyView.
Diabetes mellitus independently increases the risk of hepatic encephalopathy following TIPS placement in patients with cirrhosis. These findings emphasize the need for careful risk assessment in patients with cirrhosis and portal hypertension complications undergoing TIPS.
Michelle Spaan, Ellen Werner, Willemijn Dijkstra, Nicole E. Erler, Diederik Bijdevaate, Sarwa Darwish Murad, Milan J. Sonneveld, Caroline M. den Hoed, Anne van Eldere, Dave S. Sprengers, Willem‐Pieter Brouwer, Robert J. de Knegt, Harry L. A. Janssen, Kay Pieterman, Sandra Coenen, Raoel Maan, Adriaan J. van der Meer   +16 more
wiley   +1 more source

Characterisation and Prognostic Implication of Cholestasis After Burn Injury

Alimentary Pharmacology &Therapeutics, EarlyView.
In 532 burn ICU patients, we quantified trajectories of cholestasis markers and validated burn‐associated cholestasis definitions. Bilirubin dynamics, particularly hyperbilirubinemia ≥ 2× ULN within 14 days, independently predicted excess in‐hospital and overall mortality beyond burn and critical‐illness severity, identifying a high‐risk subgroup after
Lorenz Semmler, Georg Semmler, Andreas Langa, Sebastian Rihl, Sebastian Hofstetter, Melissa‐Patricia Mateas, Kevin Dilmen, Anton Borger, Paul Supper, Patrick Haselwanter, Emina Halilbasic, Christian Zauner, Albert Stättermayer, Gerald Ihra, Christine Radtke, Mathias Anselm Schneeweiss‐Gleixner, Michael Trauner   +16 more
wiley   +1 more source

Safety of Immune Checkpoint Inhibitors Prior to Liver Transplantation in Hepatocellular Carcinoma

Alimentary Pharmacology &Therapeutics, EarlyView.
Patients who received immune checkpoint inhibitors before liver transplant for the treatment of hepatocellular carcinoma had rejection and survival outcomes comparable to those without ICI exposure. Most rejection episodes were effectively managed with medical therapy.
L. Aceituno, C. Magyar, P. Tabrizian, R. Marino, K. Watt, D. Chascsa, G. Schnickel, V. Banz, F. Alconchel, Celia Martagon, C. Moctezuma, T. Baker, C. Nwaduru, F. J. Krendl, R. Oberhuber, L. Ruiz‐Ortega, C. Demers, R. Bucur, G. O'Kane, A. Vogel, B. Mínguez, G. Sapisochin   +21 more
wiley   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Steatotic Liver Disease: A Key Related Risk Factor in the Emergence of Metabolic Syndrome‐Related Disorders

Hepatology Research, EarlyView.
It is speculated that the onset of obesity‐related diseases follows the sequence of obesity → SLD → MetS‐related diseases. In this study, the contribution of SLD to each MetS‐related disease was large for T2D and hypertension and SLD contributed to the onset and new onset of the disease by the 7‐year follow‐up.
Yoshihiro Kamada, Makoto Fujii, Hitoshi Nishizawa, Shiro Fukuda, Makoto Yamada, Iichiro Shimomura, Eiji Miyoshi   +6 more
wiley   +1 more source