Results 41 to 50 of about 35,575 (190)

Flexible joint models for multivariate longitudinal and time-to-event data using multivariate functional principal components [PDF]

arXiv, 2023
The joint modeling of multiple longitudinal biomarkers together with a time-to-event outcome is a challenging modeling task of continued scientific interest. In particular, the computational complexity of high dimensional (generalized) mixed effects models often restricts the flexibility of shared parameter joint models, even when the subject-specific ...
arxiv  

Alveolar Echinococcosis in a Patient with Presumed Autoimmune Hepatitis and Primary Sclerosing Cholangitis: An Unexpected Finding after Liver Transplantation

Pathogens, 2023
Primary sclerosing cholangitis is an important reason for liver transplantation. Hepatic alveolar echinococcosis (AE) is caused by Echinococcus multilocularis and presents characteristic calcified conglomerates detected by ultrasound or computed ...
Florian Fronhoffs, Leona Dold, Marijo Parčina, Arne Schneidewind, Maria Willis, Thomas F. E. Barth, Tobias J. Weismüller, Taotao Zhou, Philipp Lutz, Julian A. Luetkens, Peter Gerlach, Steffen Manekeller, Jörg C. Kalff, Tim O. Vilz, Christian P. Strassburg, Glen Kristiansen   +15 more
doaj   +1 more source

Sclerosing Cholangitis in Behçet’s Disease

Case Reports in Medicine, 2013
Introduction. Sclerosing cholangitis is characterized by an inflammatory and fibrotic lesion of intra- and/or extrahepatic bile ducts. When a causal mechanism of a bile duct lesion is identified, the sclerosing cholangitis is considered secondary.
Aida Ben Slama Trabelsi, Dhilel Issaoui, Mehdi Ksiaa, Ahlem Souguir, Nadia Mama, Ahlem Brahem, Ali Jmaa, Salem Ajmi   +7 more
doaj   +1 more source

Atypical presentation of autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome associated with hypereosinophilia: a case report and review of the literature

Journal of Medical Case Reports, 2021
Background Autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome is a form of autoimmune hepatitis with cholestatic features and is characterized by negative anti-mitochondrial antibody and cholangiographic changes on magnetic resonance ...
Behzad Hatami, Hamide Rahmani Seraji, Mohaddese fallahi   +2 more
doaj   +1 more source

Outcomes in liver transplantation: does sex matter? [PDF]

, 2015
A growing literature has highlighted important differences in transplant-related outcomes between men and women. In the United States there are fewer women than men on the liver transplant waitlist and women are two times less likely to receive a ...
Berenguer, Marina, Sarkar, Monika, Terrault, Norah, Watt, Kymberly D   +3 more
core   +2 more sources

Liver involvement in pediatric celiac disease [PDF]

, 2015
Celiac disease (CD) is an intestinal inflammatory disease that manifests in genetically susceptible individuals when exposed to dietary gluten. It is a common chronic disorder, with a prevalence of 1% in Europe and North America.
Anania, Caterina, Chiesa, Claudio, De Castro, Giovanna, De Luca, Ester, Pacifico, Lucia   +4 more
core   +1 more source

Effect of Mild to Moderate Hepatic Impairment on Valemetostat Pharmacokinetics: An Open‐Label, Phase I Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana, Thuy Vu Craveiro, Thomas C. Marbury, Samuel Oberstein, George J. Atiee, Ben Tao, Takako Shimizu, Yvonne Lau, Malaz A. Abutarif   +8 more
wiley   +1 more source

A Gentleman with Anemia and Cholestasis

Case Reports in Medicine, 2010
Primary sclerosing cholangitis is a rare cause of cholestasis caused by progressive inflammation and fibrosis of both intrahepatic and extrahepatic bile ducts leading to multifocal ductal strictures.
Siu-Tong Law, Wai-Ki Lee, Michael Kin-Kong Li, Ka-Ho Lok   +3 more
doaj   +1 more source

Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholagnitis [PDF]

, 2018
The non-invasive differentiation of malignant and benign biliary disease is a clinical challenge. Carbohydrate antigen 19-9 (CA19-9), leucine-rich α2-glycoprotein (LRG1), interleukin 6 (IL6), pyruvate kinase M2 (PKM2), cytokeratin 19 fragment (CYFRA21.1)
Blyuss, O, Cuenco, J, Dawnay, A, Kazarian, A, Manns, MP, Menon, U, Pereira, SP, Timms, JF, Wehnert, N, Whitwell, HJ   +9 more
core   +2 more sources

Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci

Nature Communications
Genome-wide association studies of primary sclerosing cholangitis have identified 23 susceptibility loci. The majority of these loci reside in non-coding regions of the genome and are thought to exert their effect by perturbing the regulation of nearby ...
Elizabeth C. Goode, Laura Fachal, Nikolaos Panousis, Loukas Moutsianas, Rebecca E. McIntyre, Benjamin Yu Hang Bai, Norihito Kawasaki, Alexandra Wittmann, Tim Raine, Simon M. Rushbrook, Carl A. Anderson   +10 more
doaj   +1 more source