Results 81 to 90 of about 25,411 (289)
Nutrients, 2019 Vitamin D metabolism is actively modulated in adipose tissue during obesity. To better investigate this process, we develop a specific LC-HRMS/MS method that can simultaneously quantify three vitamin D metabolites, i.e., cholecalciferol, 25 ...
Laurianne Bonnet +7 more
semanticscholar +1 more source
Advanced Functional Materials, Volume 36, Issue 3, 8 January 2026.A biofabricated 3D in vitro model recapitulating endochondral ossification (ECO) is described, mimicking the steps from condensation to chondrogenesis and hypertrophy, culminating with vascularization of the hypertrophic construct. As a model proof of concept application, Ewing Sarcoma cells are seeded in the model, showing modifications in their ...
Maria Vittoria Colombo +13 more
wiley +1 more source
Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids
Advanced Science, Volume 13, Issue 4, 19 January 2026.Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang +6 more
wiley +1 more source
Burosumab in Unidentifiable Tumor‐Induced Osteomalacia
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Tumor‐induced osteomalacia (TIO) can be challenging due to underlying tumors being either unresectable or unidentifiable. Burosumab, an anti‐FGF23 monoclonal antibody, has been proven to be effective in treating TIO but is currently not subsidized for this indication in Australia.
Yi Shan Der +5 more
wiley +1 more source
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Cognitive impairment in Sjögren's disease (SD) is typically attributed to autoimmune mechanisms or small vessel disease. However, its overlap with neurodegenerative pathology remains poorly understood. We report a 74‐year‐old woman with clinically diagnosed SD presenting with progressive memory decline.
Eliza Georgiou +6 more
wiley +1 more source
Cholesteryl Fatty Acid Esters and Free Cholesterol in Food of Animal Origin
European Journal of Lipid Science and Technology, Volume 128, Issue 1, January 2026.Cholesterol occurs in free (bioavailable) and esterified (transport/storage) forms. Here, we present a method that allows both forms to be determined independently. Finally, the quantities of free and esterified cholesterol were determined in several meat, animal fat, and cheese samples.
Vanessa Hermann‐Ene +3 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 1, January 2026.The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima +15 more
wiley +1 more source
Journal of Cellular Physiology, Volume 241, Issue 1, January 2026.ABSTRACT Patients with chronic kidney disease, and particularly those under hemodialysis, are prone to develop cardiovascular complications, mostly due to the exacerbation of vascular calcification. Vascular calcification relies on the transdifferentiation of vascular smooth muscle cells into calcifying cells.
Najwa Skafi +16 more
wiley +1 more source