Results 61 to 70 of about 18,704 (213)

Evidence for a Direct Interaction between the Penultimate Aspartic Acid of Cholecystokinin and Histidine 207, Located in the Second Extracellular Loop of the Cholecystokinin B Receptor [PDF]

, 1999
International audienceRecently, we reported that the mutation of His(207) to Phe located in the second extracellular loop of the cholecystokinin B receptor strongly affected cholecystokinin (CCK) binding (Silvente-Poirot, S., Escrieut, C., and Wank, S. A.
Silvente-Poirot, Sandrine, Bouisson, Michelle, Martinez, Jean, Maigret, Bernard, Escherich, Achim, Vaysse, Nicole, Escrieut, Chantal, Wank, Stephen, Fourmy, Daniel, Fehrentz, Jean-Alain, Moroder, Luis, Galès, Céline   +11 more
core   +1 more source

Fluorescence studies on the binding between 1-47 fragment of cholecystokinin receptor CCKA-R(1-47) and nonsulfated cholecystokinin octapeptide CCK8 [PDF]

, 2001
The interaction between the 1-47 N-terminus fragment of the cholecystokinin receptor and the nonsulfated cholecystokinin octapeptide, CCK8, is monitored by fluorescence emission.
PEDONE C., RAGONE R., DE LUCA S., TESAURO, DIEGO, MORELLI, GIANCARLO   +4 more
core   +2 more sources

Kidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway [PDF]

Diabetes & Metabolism Journal
Background Both sodium-glucose cotransporters (SGLTs) and Na+/H+ exchangers (NHEs) rely on a favorable Na-electrochemical gradient. Gastrin, through the cholecystokinin B receptor (CCKBR), can induce natriuresis and diuresis by inhibiting renal NHEs ...
Xue Zhang, Yuhan Zhang, Yang Shi, Dou Shi, Min Niu, Xue Liu, Xing Liu, Zhiwei Yang, Xianxian Wu   +8 more
doaj   +1 more source

Energy Metabolism and Turnover Are Increased in Mice Lacking the Cholecystokinin-B Receptor [PDF]

The Journal of Nutrition, 2002
Cholecystokinin (CCK) is an important gastrointestinal hormone as well as a neurotransmitter. Two types of CCK receptors, types A and B, have been identified. The CCK-A receptor is involved in satiety, food intake and behavior, whereas the B receptor is involved in anxiety.
Kyoko, Miyasaka, Mineko, Ichikawa, Minoru, Ohta, Setsuko, Kanai, Yuki, Yoshida, Masao, Masuda, Aki, Nagata, Toshimitsu, Matsui, Tetsuo, Noda, Soichi, Takiguchi, Yutaka, Takata, Takako, Kawanami, Akihiro, Funakoshi   +12 more
openaire   +2 more sources

Glucocorticoids and HPA axis regulation in the stress–obesity connection: A comprehensive overview of biological, physiological and behavioural dimensions

Clinical Obesity, Volume 15, Issue 2, April 2025.
Summary Chronic stress, characterized by increased long‐term exposure to the glucocorticoid hormone cortisol, is increasingly linked to obesity development. Still, various knowledge gaps persist, including on underlying pathophysiological mechanisms. The aim of the current review is to provide the latest insights on the connection between stress and ...
Robin Lengton, Myrte Schoenmakers, Brenda W. J. H. Penninx, Mariëtte R. Boon, Elisabeth F. C. van Rossum   +4 more
wiley   +1 more source

The melanocortin receptors and their accessory proteins. [PDF]

, 2013
The five melanocortin receptors (MCRs) named MC1R-MC5R have diverse physiological roles encompassing pigmentation, steroidogenesis, energy homeostasis and feeding behavior as well as exocrine function.
Adrian J. L. Clark, Li eChan, Clark, AJ, Rebecca J. Gorrigan, Shwetha Ramachandrappa, Rebecca eGorrigan, Adrian eClark, Shwetha eRamachandrappa, Ramachandrappa, S, Gorrigan, RJ, Li F. Chan, Chan, LF, Clark, AJL   +12 more
core   +1 more source

The Role of Cholecystokinin in Peripheral Taste Signaling in Mice

Frontiers in Physiology, 2017
Cholecystokinin (CCK) is a gut hormone released from enteroendocrine cells. CCK functions as an anorexigenic factor by acting on CCK receptors expressed on the vagal afferent nerve and hypothalamus with a synergistic interaction between leptin.
Ryusuke Yoshida, Ryusuke Yoshida, Misa Shin, Misa Shin, Keiko Yasumatsu, Keiko Yasumatsu, Shingo Takai, Mayuko Inoue, Mayuko Inoue, Noriatsu Shigemura, Soichi Takiguchi, Seiji Nakamura, Yuzo Ninomiya, Yuzo Ninomiya, Yuzo Ninomiya   +14 more
doaj   +1 more source

Postponement of Satiety by Blockade of Brain Cholecystokinin (CCK-B) Receptors

Science, 1989
Exogenous cholecystokinin (CCK) decreases food intake and causes satiety in animals and man. However, it has not been established that endogenous CCK causes satiety or whether the response is mediated by peripheral-type (CCK-A) or brain-type (CCK-B) receptors.
Dourish, C, Rycroft, W, Iversen, S
openaire   +2 more sources

Significant reduction of activity retention in the kidneys via optimized linker sequences in radiohybrid-based minigastrin analogs

EJNMMI Research
Background We recently introduced radiohybrid (rh)-based minigastrin analogs e.g., DOTA-rhCCK-18 (DOTA-D-Dap(p-SiFA)-(D-γ-Glu)8-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2), that revealed substantially increased activity retention in the tumor.
Nadine Holzleitner, Sebastian Fischer, Isabel Maniyankerikalam, Roswitha Beck, Constantin Lapa, Hans-Jürgen Wester, Thomas Günther   +6 more
doaj   +1 more source

The Expressing Patterns of Opioid Peptides, Anti-opioid Peptides and Their Receptors in the Central Nervous System Are Involved in Electroacupuncture Tolerance in Goats

Frontiers in Neuroscience, 2018
To investigate dynamic processes of enkephalin (ENK), cholecystokinin octapeptide (CCK-8), orphanin FQ (OFQ) and their receptors (μ opioid receptor, MOR; CCK B type receptor, CCKBR and opioid receptor-like 1 receptor, OPRL1) in the central nerve system ...
Juan Wan, Zhengying Qiu, Zhengying Qiu, Yi Ding, Sha Nan, Mingxing Ding   +5 more
doaj   +1 more source