Results 1 to 10 of about 35,002 (214)
Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences [PDF]
The Journal of Poultry ScienceGlucose is the primary substrate for cellular energy production, and its blood concentration is tightly regulated. This study investigated the effect of glucose supplementation during the first three days post-hatching on growth performance and ...
Kazuki Kimura +6 more
doaj +2 more sources
Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice [PDF]
, 2014 Duchenne muscular dystrophy (DMD) is a neuromuscular disease that arises from mutations in the dystrophin-encoding gene. Apart from muscle pathology, cognitive impairment, primarily of developmental origin, is also a significant component of the disorder.
Gorecki, Dariusz C. +3 more
core +10 more sources
Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics
Frontiers in Endocrinology, 2021 Cholecystokinin is a gastrointestinal peptide hormone with important roles in metabolic physiology and the maintenance of normal nutritional status, as well as potential roles in the prevention and management of obesity, currently one of the dominant ...
Laurence J. Miller +3 more
doaj +1 more source
Single-chain Fragment variable antibody targeting cholecystokinin-B receptor for pain reduction
Neurobiology of Pain, 2021 The cholecystokinin B receptor and its neuropeptide ligand are upregulated in chronic neuropathic pain models. Single-chain Fragment variable antibodies were generated as preferred non-opioid targeting therapy blocking the cholecystokinin B receptor to ...
K.N. Westlund +7 more
doaj +1 more source
CCK2 receptors in chronic pain
Neurobiology of Pain, 2022 The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a historic target for pain management that has shown limited success. However, new approaches to target CCK2R have incited fresh enthusiasm for this target.
Justin E. LaVigne, Sascha R.A. Alles
doaj +1 more source
Molecular Metabolism, 2022 Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications to reduce appetite and body weight. These actions are centrally mediated; however, the neuronal substrates involved are poorly understood.
Alessia Costa +13 more
doaj +1 more source
Stress, 2023 The heart is the main organ of the circulatory system and requires fatty acids to maintain its activity. Stress is a contributor to aggravating cardiovascular diseases and even death, and exacerbates the abnormal lipid metabolism.
Zhi-Hua Zhang +6 more
doaj +1 more source
Cholecystokinin-A signaling regulates automaticity of pacemaker cardiomyocytes
Frontiers in Physiology, 2023 Aims: The behavior of pacemaker cardiomyocytes (PCs) in the sinoatrial node (SAN) is modulated by neurohormonal and paracrine factors, many of which signal through G-protein coupled receptors (GPCRs).
Hongmei Ruan +7 more
doaj +1 more source
Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization. [PDF]
PLoS ONE, 2013 Schizophrenia is a psychiatric disorder associated with atypical handedness and language lateralization. However, the molecular mechanisms underlying these functional changes are still poorly understood.
Sebastian Ocklenburg +5 more
doaj +1 more source
The Cholecystokinin Type 2 Receptor, a Pharmacological Target for Pain Management
Pharmaceuticals, 2021 Over the past decades, accumulating evidence has demonstrated a pivotal role of cholecystokinin type 2 receptor (CCK2R) in pain modulation. The established role of CCK2R activation in directly facilitating nociception has led to the development of ...
Amandine Bernard +7 more
doaj +1 more source