Results 11 to 20 of about 21,687 (230)
Archives of Medical Science, 2022 Introduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS).
Eva Drnovsek +6 more
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Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation [PDF]
Molecular Metabolism, 2022 Objective: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective medications to reduce appetite and body weight. These actions are centrally mediated; however, the neuronal substrates involved are poorly understood.
Alessia Costa +13 more
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Purification of the pancreatic cholecystokinin receptor [PDF]
Regulatory Peptides, 1989 We have previously shown that the pancreatic cholecystokinin (CCK) receptor can be solubilized in 1% digitonin. In this study, digitonin-solubilized CCK receptors from rat pancreas were purified using sequential affinity chromatography on ricin-II agarose and on AffiGel-CCK. Electrophoresis of the radioiodinated purified receptors on SDS-polyacrylamide
Szecowka, J. +3 more
openaire +4 more sources
Expression of gastrin and cholecystokinin B receptor in Lateolabrax maculatus
Aquaculture and Fisheries, 2023 Gastrin (gas) is a peptide hormone that stimulates gastric acid secretion by gastric parietal cells and stimulates gastric motility. The cholecystokinin B receptor (cckbr) can act as a receptor for gastrin, conveying regulatory information on gastrin ...
Tingwen Cui +3 more
doaj +2 more sources
Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences [PDF]
The Journal of Poultry ScienceGlucose is the primary substrate for cellular energy production, and its blood concentration is tightly regulated. This study investigated the effect of glucose supplementation during the first three days post-hatching on growth performance and ...
Kazuki Kimura +6 more
doaj +2 more sources
Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence [PDF]
BMC Neuroscience, 2012 Background Cholecystokinin octapeptide (CCK-8), the most potent endogenous anti-opioid peptide, has been shown to regulate the processes of morphine dependence.
Wen Di +6 more
doaj +2 more sources
Roles of Cholecystokinin in the Nutritional Continuum. Physiology and Potential Therapeutics
Frontiers in Endocrinology, 2021 Cholecystokinin is a gastrointestinal peptide hormone with important roles in metabolic physiology and the maintenance of normal nutritional status, as well as potential roles in the prevention and management of obesity, currently one of the dominant ...
Laurence J. Miller +3 more
doaj +1 more source
Single-chain Fragment variable antibody targeting cholecystokinin-B receptor for pain reduction
Neurobiology of Pain, 2021 The cholecystokinin B receptor and its neuropeptide ligand are upregulated in chronic neuropathic pain models. Single-chain Fragment variable antibodies were generated as preferred non-opioid targeting therapy blocking the cholecystokinin B receptor to ...
K.N. Westlund +7 more
doaj +1 more source
CCK2 receptors in chronic pain
Neurobiology of Pain, 2022 The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a historic target for pain management that has shown limited success. However, new approaches to target CCK2R have incited fresh enthusiasm for this target.
Justin E. LaVigne, Sascha R.A. Alles
doaj +1 more source
Stress, 2023 The heart is the main organ of the circulatory system and requires fatty acids to maintain its activity. Stress is a contributor to aggravating cardiovascular diseases and even death, and exacerbates the abnormal lipid metabolism.
Zhi-Hua Zhang +6 more
doaj +1 more source