Results 11 to 20 of about 35,026 (238)
Structural insights into human brain–gut peptide cholecystokinin receptors
Cell Discovery, 2022 The intestinal hormone and neuromodulator cholecystokinin (CCK) receptors CCK1R and CCK2R act as a signaling hub in brain–gut axis, mediating digestion, emotion, and memory regulation.
Yu Ding +11 more
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Molecular Models for Cholecystokinin‐A Receptor [PDF]
Pharmacology & Toxicology, 2002 Abstract: Numerous techniques have been used to elucidate the structural basis for interaction of cholecystokinin (CCK)‐related peptides with their hormone‐binding receptor, the CCK‐A receptor (CCK‐AR), including structure‐activity relationship studies, site‐directed mutagenesis, photoaffinity‐labeling, and solution NMR analysis of both CCK peptide ...
Eric S, Dawson +3 more
openaire +2 more sources
Archives of Medical Science, 2022 Introduction Cholecystokinin (CCK) is involved in several metabolic pathways, and CCK agonists are considered as a potential novel treatment option in populations with increased metabolic risk, including polycystic ovary syndrome (PCOS).
Eva Drnovsek +6 more
doaj +1 more source
The evolution and variety of RFamide-type neuropeptides: insights from deuterostomian invertebrates [PDF]
, 2014 Five families of neuropeptides that have a C-terminal RFamide motif have been identified in vertebrates: (1) gonadotropin-inhibitory hormone (GnIH), (2) neuropeptide FF (NPFF), (3) pyroglutamylated RFamide peptide (QRFP), (4) prolactin-releasing peptide (
Elphick, MR, Mirabeau, O
core +1 more source
Nature Communications, 2023 The underlying mechanisms of how obesity increases asthma prevalence and severity are not well understood. Here, the authors show that antagonizing cholecystokinin and its receptor, CCKAR, in the lung attenuates obesity-associated airway ...
Ronald Allan M. Panganiban +15 more
doaj +1 more source
Expression of gastrin and cholecystokinin B receptor in Lateolabrax maculatus
Aquaculture and Fisheries, 2023 Gastrin (gas) is a peptide hormone that stimulates gastric acid secretion by gastric parietal cells and stimulates gastric motility. The cholecystokinin B receptor (cckbr) can act as a receptor for gastrin, conveying regulatory information on gastrin ...
Tingwen Cui +3 more
doaj +1 more source
Bioactivity in Whey Proteins Influencing Energy Balance [PDF]
, 2012 Peer-reviewedObesity develops due to energy (food) intake exceeding energy expenditure. Nutrients that reduce the positive energy balance are thus being considered as therapies to combat obesity.
Cotter, Paul D. +4 more
core +1 more source
Animal, 2015 This study was conducted to investigate the effects of rumen-protected γ-aminobutyric acid (GABA) on feed intake, growth performance and expression of related genes in growing lambs.
D.M. Wang +5 more
doaj +1 more source
Lipase inhibition attenuates the acute inhibitory effects of oral fat on food intake in healthy subjects [PDF]
, 2003 The lipase inhibitor, orlistat, is used in the treatment of obesity and reduces fat absorption by about 30%. However, the mean weight loss induced by orlistat is less than expected for the degree of fat malabsorption.
Feinle-Bisset, C. +3 more
core +2 more sources
The peripheral cholecystokinin receptors
European Journal of Biochemistry, 1993 Cholecystokinin (CCK), one of the first discovered gastrointestinal hormones [1, 2] was originally isolated from the porcine duodenum as a 33-amino-acid peptide (CCK-33) [3–5]. The sequencing of CCK-33 in 1968 revealed that the peptide is structurally related to gastrin, another gut hormone characterized four years earlier [6]. Indeed, the two peptides
Silvente-Poirot, Sandrine +3 more
openaire +2 more sources