Results 21 to 30 of about 21,687 (230)
Cholecystokinin-A signaling regulates automaticity of pacemaker cardiomyocytes
Frontiers in Physiology, 2023 Aims: The behavior of pacemaker cardiomyocytes (PCs) in the sinoatrial node (SAN) is modulated by neurohormonal and paracrine factors, many of which signal through G-protein coupled receptors (GPCRs).
Hongmei Ruan +7 more
doaj +1 more source
Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization. [PDF]
PLoS ONE, 2013 Schizophrenia is a psychiatric disorder associated with atypical handedness and language lateralization. However, the molecular mechanisms underlying these functional changes are still poorly understood.
Sebastian Ocklenburg +5 more
doaj +1 more source
The Cholecystokinin Type 2 Receptor, a Pharmacological Target for Pain Management
Pharmaceuticals, 2021 Over the past decades, accumulating evidence has demonstrated a pivotal role of cholecystokinin type 2 receptor (CCK2R) in pain modulation. The established role of CCK2R activation in directly facilitating nociception has led to the development of ...
Amandine Bernard +7 more
doaj +1 more source
Structural insights into human brain–gut peptide cholecystokinin receptors
Cell Discovery, 2022 The intestinal hormone and neuromodulator cholecystokinin (CCK) receptors CCK1R and CCK2R act as a signaling hub in brain–gut axis, mediating digestion, emotion, and memory regulation.
Yu Ding +11 more
doaj +1 more source
Molecular Models for Cholecystokinin‐A Receptor [PDF]
Pharmacology & Toxicology, 2002 Abstract: Numerous techniques have been used to elucidate the structural basis for interaction of cholecystokinin (CCK)‐related peptides with their hormone‐binding receptor, the CCK‐A receptor (CCK‐AR), including structure‐activity relationship studies, site‐directed mutagenesis, photoaffinity‐labeling, and solution NMR analysis of both CCK peptide ...
Eric S, Dawson +3 more
openaire +2 more sources
Regulation of fat-stimulated neurotensin secretion in healthy subjects [PDF]
, 2008 CONTEXT: Cholecystokinin (CCK) and neurotensin are stimulated during meal intake by the presence of fat in the small intestine. The sequence of events suggests that fat hydrolysis is crucial for triggering the release.
Drewe, J. +3 more
core +1 more source
Animal, 2015 This study was conducted to investigate the effects of rumen-protected γ-aminobutyric acid (GABA) on feed intake, growth performance and expression of related genes in growing lambs.
D.M. Wang +5 more
doaj +1 more source
Nature Communications, 2023 The underlying mechanisms of how obesity increases asthma prevalence and severity are not well understood. Here, the authors show that antagonizing cholecystokinin and its receptor, CCKAR, in the lung attenuates obesity-associated airway ...
Ronald Allan M. Panganiban +15 more
doaj +1 more source
The peripheral cholecystokinin receptors
European Journal of Biochemistry, 1993 Cholecystokinin (CCK), one of the first discovered gastrointestinal hormones [1, 2] was originally isolated from the porcine duodenum as a 33-amino-acid peptide (CCK-33) [3–5]. The sequencing of CCK-33 in 1968 revealed that the peptide is structurally related to gastrin, another gut hormone characterized four years earlier [6]. Indeed, the two peptides
Silvente-Poirot, Sandrine +3 more
openaire +2 more sources
Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor
Scientific Reports, 2022 The cholecystokinin-2 receptor (CCK2R) is a G protein-coupled receptor (GPCR) that is expressed in peripheral tissues and the central nervous system and constitutes a promising target for drug development in several diseases, such as gastrointestinal ...
Mohammad Sadegh Taghizadeh +8 more
doaj +1 more source