Results 81 to 90 of about 3,700 (219)

Mechanochemische Methoden mit Anwendung in der Late‐Stage Modifizierung Pharmazeutisch Wirksamer Verbindungen

open access: yesAngewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Dieser Review diskutiert mechanochemische Strategien zur späten Modifizierung bioaktiver Wirkstoffe und bietet zugleich eine wertvolle Übersicht zur Auswahl geeigneter Substrate, um das pharmazeutische Potenzial neuer und bestehender (mechano)chemischer Verfahren zu evaluieren.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Сerebrotendinous xanthomatosis

open access: yesАнналы клинической и экспериментальной неврологии, 2017
Cerebrotendinous xanthomatosis is a rare autosomal recessivedisorder of cholesterol and bile acid metabolism associated withthe sterol 27-hydroxylase gene CYP27A1.
G. E. Rudenskaya, E. Yu. Zakharova
doaj   +1 more source

Analysis of phytosterols in foods [PDF]

open access: yes, 2006
Phytosterols are bioactive compounds, one of their most studied and outstanding properties being their cholesterol-lowering activity. This explains the growing interest in the phytosterol contents of foods as either intrinsic or added components.
Farré Rovira, Rosaura   +2 more
core   +1 more source

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

open access: yesAnnals of Neurology, Volume 98, Issue 3, Page 448-470, September 2025.
[Color figure can be viewed at www.annalsofneurology.org] Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical ...
Brent L. Fogel   +10 more
wiley   +1 more source

Characteristics of Lipid Biomarkers (N-alkanes, Fatty Acids, Sterols, N-alkanols and Isoprenoid) in Estuarine Sediments of Muara Angke Jakarta Bay and Cilintang-ujung Kulon [PDF]

open access: yes, 2014
Lipid biomarkers as specific organic compounds can be used to evaluate the possible contribution of organic carbon from different sources or to trace the biological origin of molecules.
Nugraha, M. A. (Mohammad)   +2 more
core  

Recent Advances in Detergent Chemistry and Handling Support Membrane Protein Analysis Including Lipid Interactions

open access: yesChemistry – A European Journal, Volume 31, Issue 49, September 1, 2025.
Detergent design parameters determine experimental successes in membrane protein research. Recent progresses in detergent chemistry are reviewed to promote the top‐down design of non‐ionic detergents for the purification and analysis of intact membrane proteins, including lipid interactions.
Katharina Alker   +2 more
wiley   +1 more source

The intracellular distribution of sterols in Eurycotis floridana and its possible relation to subcellular membrane structures

open access: yesJournal of Lipid Research, 1966
The roach Eurycotis floridana was reared on a semisynthetic diet containing minimal cholesterol-4-14C (0.005%) supplemented with cholestanol-7α-3H (0.1%), and various tissues of the insect were separated into ``nuclear,'' ``mitochondrial,'' and ...
N.L. Lasser, R.B. Clayton
doaj   +1 more source

Deposition of Cholesterol and Cholestanol in Experimental Rabbit Atherosclerosis.

open access: yesExperimental Biology and Medicine, 1961
SummaryContrary to the original findings it is established that cholesterol-C14 and cholesterol-H3 are deposited in tissues of rabbits in exactly the same way. The reason for the discrepancy in deposition of the two substances in earlier experiments was found in the presence of chemically negligible traces of cholestanol-H3 which had then not been ...
E, SCHWENK, Y, OMORI, E, JOACHIM
openaire   +2 more sources

Increased plasma cholestanol and 5 alpha-saturated plant sterol derivatives in subjects with sitosterolemia and xanthomatosis.

open access: yesJournal of Lipid Research, 1985
We have measured plasma sterol composition in 14 subjects with sitosterolemia and xanthomatosis. In addition to elevated plasma phytosterol (campesterol 16 +/- 7 mg/dl and sitosterol 35 +/- 16 mg/dl) and normal to moderately high cholesterol levels (258 +
G Salen   +7 more
doaj   +1 more source

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