Results 1 to 10 of about 116,093 (277)

Cholestasis: exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies

Gut Microbes, 2023
Cholestasis is a condition characterized by the abnormal production or excretion of bile, and it can be induced by a variety of causes, the factors of which are extremely complex.
Leilei Yu, Yaru Liu, Shunhe Wang, Qingsong Zhang, Jianxin Zhao, Hao Zhang, Arjan Narbad, Fengwei Tian, Qixiao Zhai, Wei Chen   +9 more
doaj   +2 more sources

Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study.

PLoS ONE, 2020
INTRODUCTION:Previous studies of fetal effects have suggested that intrahepatic cholestasis of pregnancy is associated with a higher rate of adverse neonatal outcomes including preterm birth, neonatal respiratory distress syndrome, meconium-stained ...
Chloé Arthuis, Caroline Diguisto, Henri Lorphelin, Vincent Dochez, Emmanuel Simon, Franck Perrotin, Norbert Winer   +6 more
doaj   +2 more sources

Pathophysiology of sepsis‐induced cholestasis: A review

JGH Open, 2022
Sepsis is a critical condition resulting from the excessive activation of the inflammatory/immune system in response to an infection, with high mortality if treatment is not administered promptly. One of the many possible complications of sepsis is liver
Maria Iuliana Ghenu, Dorin Dragoş, Maria Mirabela Manea, Dorin Ionescu, Lucian Negreanu   +4 more
doaj   +2 more sources

Severe cholestasis in neonatal extracorporeal membrane oxygenation [PDF]

The Journal of ExtraCorporeal Technology
Introduction: Cholestasis is a common complication of Extracorporeal Membrane Oxygenation (ECMO) secondary to patient physiology and circuit-induced factors.
Jancaric Michelle, Langworthy Benjamin, Guiang Sixto, Segura Bradley, Wallace Rachel, Larson-Nath Catherine, Satrom Katherine M.   +6 more
doaj   +2 more sources

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications

Canadian Journal of Gastroenterology and Hepatology, 2018
Cholestasis is characterised by impaired bile secretion and accumulation of bile salts in the organism. Hereditary cholestasis is a heterogeneous group of rare autosomal recessive liver disorders, which are characterised by intrahepatic cholestasis ...
Eva Sticova, Milan Jirsa, Joanna Pawłowska   +2 more
doaj   +2 more sources

Outcomes of 38 patients with PFIC3: Impact of genotype and of response to ursodeoxycholic acid therapy

JHEP Reports, 2023
Background & Aims: Progressive familial intrahepatic cholestasis type 3 (PFIC3) is a rare liver disease caused by biallelic variations in ABCB4. Data reporting on the impact of genotype and of response to ursodeoxycholic acid (UDCA) therapy on long ...
Emmanuel Gonzales, Antoine Gardin, Marion Almes, Amaria Darmellah-Remil, Hanh Seguin, Charlotte Mussini, Stéphanie Franchi-Abella, Mathieu Duché, Oanez Ackermann, Alice Thébaut, Dalila Habes, Bogdan Hermeziu, Martine Lapalus, Thomas Falguières, Jean-Philippe Combal, Bernard Benichou, Sonia Valero, Anne Davit-Spraul, Emmanuel Jacquemin   +18 more
doaj   +1 more source

Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy

Nature Communications, 2023
Intrahepatic cholestasis of pregnancy (ICP) is a female pregnancy-specific disorder that is characterized by increased serum bile acid and adverse fetal outcomes.
Bo Tang, Li Tang, Sheng-Yang Li, Shuang Liu, Jialin He, Pan Li, Sumin Wang, Min Yang, Longhui Zhang, Yuanyuan Lei, Dianji Tu, Xuefeng Tang, Hua Hu, Q. Ouyang, Xia Chen, Shiming Yang   +15 more
semanticscholar   +1 more source

Effect of transient obstructive cholestasis on liver histology: a cross-sectional study

São Paulo Medical Journal, 2021
BACKGROUND: The role of transient obstructive cholestasis on liver histology remains undetermined. OBJECTIVE: To investigate whether transient cholestasis impairs liver histology.
Thalita Mendes Mitsunaga, Laísa Simakawa Jimenez, Pedro França da Costa Soares, Martinho Antonio Gestic, Murillo Pimentel Utrini, Felipe David Mendonça Chaim, Francisco Callejas-Neto, Elinton Adami Chaim, Everton Cazzo   +8 more
doaj   +1 more source

Runt-related transcription factor-1 ameliorates bile acid–induced hepatic inflammation in cholestasis through JAK/STAT3 signaling

Hepatology, 2023
Background and Aims: Bile acids trigger a hepatic inflammatory response, causing cholestatic liver injury. Runt-related transcription factor-1 (RUNX1), primarily known as a master modulator in hematopoiesis, plays a pivotal role in mediating inflammatory
Liangjun Zhang, Qiong-Jing Pan, Lu Zhang, Haihan Xia, Junwei Liao, Xiaoxun Zhang, Nan Zhao, Qiaoling Xie, Min Liao, Ya Tan, Qiao Li, Jinfei Zhu, Ling Li, Shijun Fan, Jianwei Li, Chengcheng Zhang, Shi-Ying Cai, J. Boyer, Jin Chai   +18 more
semanticscholar   +1 more source

Progressive cholestasis and associated sclerosing cholangitis are frequent complications of COVID‐19 in patients with chronic liver disease

Hepatology, 2022
Cholestasis is associated with disease severity and worse outcome in COVID‐19. Cases of secondary sclerosing cholangitis (SSC) after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection have been described.
L. Hartl, Katharina Haslinger, Martin Angerer, G. Semmler, M. Schneeweiss-Gleixner, M. Jachs, B. Simbrunner, D. Bauer, E. Eigenbauer, R. Strassl, M. Breuer, O. Kimberger, D. Laxar, K. Lampichler, E. Halilbasic, A. Stättermayer, A. Ba-Ssalamah, M. Mandorfer, B. Scheiner, T. Reiberger, M. Trauner   +20 more
semanticscholar   +1 more source