Results 1 to 10 of about 75,500 (262)

Cholestasis: exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies

Gut Microbes, 2023
Cholestasis is a condition characterized by the abnormal production or excretion of bile, and it can be induced by a variety of causes, the factors of which are extremely complex.
Leilei Yu, Yaru Liu, Shunhe Wang, Qingsong Zhang, Jianxin Zhao, Hao Zhang, Arjan Narbad, Fengwei Tian, Qixiao Zhai, Wei Chen   +9 more
doaj   +2 more sources

Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study.

PLoS ONE, 2020
INTRODUCTION:Previous studies of fetal effects have suggested that intrahepatic cholestasis of pregnancy is associated with a higher rate of adverse neonatal outcomes including preterm birth, neonatal respiratory distress syndrome, meconium-stained ...
Chloé Arthuis, Caroline Diguisto, Henri Lorphelin, Vincent Dochez, Emmanuel Simon, Franck Perrotin, Norbert Winer   +6 more
doaj   +2 more sources

New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications

Canadian Journal of Gastroenterology and Hepatology, 2018
Cholestasis is characterised by impaired bile secretion and accumulation of bile salts in the organism. Hereditary cholestasis is a heterogeneous group of rare autosomal recessive liver disorders, which are characterised by intrahepatic cholestasis ...
Eva Sticova, Milan Jirsa, Joanna Pawłowska   +2 more
doaj   +2 more sources

Gut microbiota alters host bile acid metabolism to contribute to intrahepatic cholestasis of pregnancy

Nature Communications, 2023
Intrahepatic cholestasis of pregnancy (ICP) is a female pregnancy-specific disorder that is characterized by increased serum bile acid and adverse fetal outcomes.
Bo Tang, Li Tang, Sheng-Yang Li, Shuang Liu, Jialin He, Pan Li, Sumin Wang, Min Yang, Longhui Zhang, Yuanyuan Lei, Dianji Tu, Xuefeng Tang, Hua Hu, Q. Ouyang, Xia Chen, Shiming Yang   +15 more
semanticscholar   +1 more source

Effect of transient obstructive cholestasis on liver histology: a cross-sectional study

São Paulo Medical Journal, 2021
BACKGROUND: The role of transient obstructive cholestasis on liver histology remains undetermined. OBJECTIVE: To investigate whether transient cholestasis impairs liver histology.
Thalita Mendes Mitsunaga, Laísa Simakawa Jimenez, Pedro França da Costa Soares, Martinho Antonio Gestic, Murillo Pimentel Utrini, Felipe David Mendonça Chaim, Francisco Callejas-Neto, Elinton Adami Chaim, Everton Cazzo   +8 more
doaj   +1 more source

Progressive cholestasis and associated sclerosing cholangitis are frequent complications of COVID‐19 in patients with chronic liver disease

Hepatology, 2022
Cholestasis is associated with disease severity and worse outcome in COVID‐19. Cases of secondary sclerosing cholangitis (SSC) after severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection have been described.
L. Hartl, Katharina Haslinger, Martin Angerer, G. Semmler, M. Schneeweiss-Gleixner, M. Jachs, B. Simbrunner, D. Bauer, E. Eigenbauer, R. Strassl, M. Breuer, O. Kimberger, D. Laxar, K. Lampichler, E. Halilbasic, A. Stättermayer, A. Ba-Ssalamah, M. Mandorfer, B. Scheiner, T. Reiberger, M. Trauner   +20 more
semanticscholar   +1 more source

CHRONIC CHOLESTASIS IN INFANCY [PDF]

Romanian Journal of Pediatrics, 2009
This article focuses on the few disorders that produce chronic cholestasis in infants. The author presents: definition and pathophysiology of cholestasis; the consequences of cholestasis; an approach to diagnosis of cholestasis in infancy and childhood;
Daniela Patrichi
doaj   +1 more source

Neonatal cholestasis as the onset symptom of McCune–Albright syndrome: case reports and a literature review

Frontiers in Pediatrics, 2023
AimThis study aimed to summarize and show the characteristics and evolutionary process of neonatal cholestasis caused by McCune–Albright syndrome (MAS), as neonatal cholestasis may be the initial manifestation of MAS before other classic clinical ...
Weiyuan Fang, Yanhui Zhang, Lian Chen, Xinbao Xie   +3 more
doaj   +1 more source

Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling

Hepatology, 2021
Cholestasis is characterized by increased total bile acid (TBA) levels, which are regulated by farnesoid X receptor (FXR)/FGF15. Patients with primary sclerosing cholangitis (PSC) typically present with inflammatory bowel disease (IBD). Mast cells (MCs) (
Vik Meadows, Lindsey Kennedy, B. Ekser, Konstantina Kyritsi, Debjyoti Kundu, Tianhao Zhou, Lixian Chen, L. Pham, Nan Wu, Jennifer Demieville, Laura A Hargrove, S. Glaser, G. Alpini, H. Francis   +13 more
semanticscholar   +1 more source

Newer variants of progressive familial intrahepatic cholestasis

World Journal of Hepatology, 2021
Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of disorders characterized by defects in bile secretion and presentation with intrahepatic cholestasis in infancy or childhood. The most common types include PFIC 1 (deficiency
Vignesh Vinayagamoorthy, A. Srivastava, M. Sarma   +2 more
semanticscholar   +1 more source