British Journal of Clinical Pharmacology, EarlyView.Ileal bile acid transporter inhibitors (IBATi), including maralixibat and odevixibat, are a novel approach to the treatment of paediatric cholestatic liver diseases, such as Alagille syndrome (ALGS) and different forms of progressive familial intrahepatic cholestasis (PFIC).
Alise D. E. de Groot +5 more
wiley +1 more source
Idiopathic Intrahepatic Cholestasis as an Unusual Presentation of Hodgkin’s Disease
Case Reports in Hematology, 2015 Intrahepatic cholestasis in the form of paraneoplastic phenomena is an uncommon presentation of Hodgkin’s lymphoma (HL). Herein we report the diagnosis of mixed type HL-related idiopathic intrahepatic cholestasis in a 73-year-old man presenting with ...
Hande Atalay +6 more
doaj +1 more source
Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis
Nature Communications, 2016 Neonatal cholestasis is a potentially life-threatening condition requiring prompt diagnosis. Mutations in several different genes can cause progressive familial intrahepatic cholestasis, but known genes cannot account for all familial cases.
N. Gomez-Ospina +28 more
semanticscholar +1 more source
Potentially harmful advantage to athletes: a putative connection between UGT2B17 gene deletion polymorphism and renal disorders with prolonged use of anabolic androgenic steroids [PDF]
, 2010 : BACKGROUND AND OBJECTIVE: With prolonged use of anabolic androgenic steroids (AAS), occasional incidents of renal disorders have been observed. Independently, it has also been established that there are considerable inter-individual and inter-ethnic ...
Barker, James +5 more
core +3 more sources
Parenteral Nutrition-Induced Cholestasis in Neonates: Where Does the Problem Lie?
Gastroenterology Research and Practice, 2013 Background. Parenteral nutrition (PN) is an effective method of nourishing the neonate who is unable to receive full enteral feeds. Cholestasis can be a complication of PN and can lead to severe liver damage. Aim.
Kheira Jolin-Dahel +5 more
doaj +1 more source
Isolated cortisol deficiency: A rare cause of neonatal cholestasis
The Saudi Journal of Gastroenterology, 2012 For decades, congenital panhypopituitarism has been recognized to cause infantile cholestasis. However, the identity of the hormone whose deficiency causes such derangement of the liver is not clear. Here, we report four cases of isolated severe cortisol
Abdulrahman Al-Hussaini +4 more
doaj +1 more source
Microbiology Spectrum, 2022 Cholestasis is characterized by bile acid (BA) circulation disorders, which is usually related to damage of hepatocyte barrier function. Currently, patients with cholestasis face several obstacles in seeking diagnosis and therapy.
Wang Wang +6 more
doaj +1 more source
Logistics and technique for combined hepatic-intestinal retrieval [PDF]
, 1992 During a 13-month period, en bloc liver-small bowel cadaveric grafts were procured for seven children and one adult. All liver grafts functioned immediately, and all but one of the recipient patients recovered.
Abu-Elmagd, K +7 more
core +2 more sources
Bile acid-gut microbiota imbalance in cholestasis and its long-term effect in mice
mSystemsCholestasis is a common morbid state that may occur in different phases; however, a comprehensive evaluation of the long-term effect post-recovery is still lacking.
Xin Yang +9 more
doaj +1 more source
Preventive effect of ursodeoxycholic acid on parenteral nutrition-associated liver disease in infants [PDF]
Srpski Arhiv za Celokupno Lekarstvo, 2014 Introduction. Parenteral nutrition-associated cholestasis is well recognized phenomenon in the term and preterm infant receiving long-term parenteral nutrition. Objectives. The aim of this study was to evaluate the effect of ursodeoxycholic acid
Simić Dušica +8 more
doaj +1 more source