Results 11 to 20 of about 116,093 (277)
CHRONIC CHOLESTASIS IN INFANCY [PDF]
Romanian Journal of Pediatrics, 2009 This article focuses on the few disorders that produce chronic cholestasis in infants. The author presents: definition and pathophysiology of cholestasis; the consequences of cholestasis; an approach to diagnosis of cholestasis in infancy and childhood;
Daniela Patrichi
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Frontiers in Pediatrics, 2023 AimThis study aimed to summarize and show the characteristics and evolutionary process of neonatal cholestasis caused by McCune–Albright syndrome (MAS), as neonatal cholestasis may be the initial manifestation of MAS before other classic clinical ...
Weiyuan Fang +3 more
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Biomarkers of Cholestasis [PDF]
Biomarkers in Medicine, 2021 Cholestasis is a major pathological manifestation, often resulting in detrimental liver conditions, which occurs in a variety of indications collectively termed cholestatic liver diseases. The frequent asymptomatic character and complexity of cholestasis, together with the lack of a straightforward biomarker, hampers early detection and treatment of ...
Pieters, Alanah +5 more
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AJOG Global Reports, 2021 BACKGROUND: Gestational diabetes and obstetrical cholestasis are common clinical conditions seen in clinical practice. There is evidence suggesting a coexisting relationship that could have a potential clinical implication related to stillbirth outcomes.
Manoj Mohan, MRCOG +3 more
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Neonatal Cholestasis: Updates on Diagnostics, Therapeutics, and Prevention.
NeoReviews, 2021 Cholestatic jaundice is a common presenting feature of hepatobiliary and/or metabolic dysfunction in the newborn and young infant. Timely detection of cholestasis, followed by rapid step-wise evaluation to determine the etiology, is crucial to identify ...
Amy G. Feldman, R. Sokol
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Seminars in Pediatric Surgery, 2000 In simplest terms, cholestasis is defined as a decrease in bile flow. The clinical manifestations of cholestasis occur because of accumulation of substances normally excreted in the bile; namely bilirubin, bile acids, and cholesterol. Accumulation of bilirubin leads to jaundice and dark urine. Accumulation of bile acids is associated with pruritus, and
F M, Karrer, D D, Bensard
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BJOG: an International Journal of Obstetrics and Gynaecology, 2021 To determine the optimal total serum bile acid (TSBA) threshold and sampling time for accurate intrahepatic cholestasis of pregnancy (ICP) diagnosis.
Alice L. Mitchell +12 more
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The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives
Frontiers in Pharmacology, 2021 Estrogens are steroid hormones with a wide range of biological activities. The excess of estrogens can lead to decreased bile flow, toxic bile acid (BA) accumulation, subsequently causing intrahepatic cholestasis.
Y. Zu +3 more
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BMC Pregnancy and Childbirth, 2022 Background Intrahepatic cholestasis of pregnancy is a pregnancy-specific liver disease. In this study, we sought to explore the distribution of lipopolysaccharide in the maternal body, and its effect on the fetal body in the intrahepatic cholestasis of ...
Xiaomei Huang +3 more
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Newer variants of progressive familial intrahepatic cholestasis
World Journal of Hepatology, 2021 Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of disorders characterized by defects in bile secretion and presentation with intrahepatic cholestasis in infancy or childhood. The most common types include PFIC 1 (deficiency
Vignesh Vinayagamoorthy +2 more
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