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Bailliere's Best Practice and Research in Clinical Gastroenterology, 2010
Progressive familial intrahepatic cholestasis (PFIC) type 1, 2 and 3 are due to mutations in ATP8B1, ABCB11 and ABCB4, respectively. Each of these genes encodes a hepatocanalicular transporter, which is essential for the proper formation of bile. Mutations in ABCB4 can result in progressive cholestatic disease, while mutations in ATP8B1 and ABCB11 can ...
Saskia W C Van Mil +2 more
exaly +4 more sources
Progressive familial intrahepatic cholestasis (PFIC) type 1, 2 and 3 are due to mutations in ATP8B1, ABCB11 and ABCB4, respectively. Each of these genes encodes a hepatocanalicular transporter, which is essential for the proper formation of bile. Mutations in ABCB4 can result in progressive cholestatic disease, while mutations in ATP8B1 and ABCB11 can ...
Saskia W C Van Mil +2 more
exaly +4 more sources
Seminars in Perinatology, 2004
Any infant who is jaundiced beyond two to three weeks of life should be evaluated for neonatal cholestasis. Neonatal cholestasis is defined as accumulation of bile substances in blood due to impaired excretion. These infants should always have fractionated serum bilirubin levels checked to differentiate the conjugated hyperbilirubinemia of cholestasis ...
Sridevi, Venigalla, Glenn R, Gourley
exaly +5 more sources
Any infant who is jaundiced beyond two to three weeks of life should be evaluated for neonatal cholestasis. Neonatal cholestasis is defined as accumulation of bile substances in blood due to impaired excretion. These infants should always have fractionated serum bilirubin levels checked to differentiate the conjugated hyperbilirubinemia of cholestasis ...
Sridevi, Venigalla, Glenn R, Gourley
exaly +5 more sources
Clinics in Liver Disease, 1993
Why do patients with cholestasis itch? The answer to this fundamental question is unknown. It is inferred that substances that accumulate in plasma and other tissues, as a result of cholestasis, cause pruritus; however, the specific nature of the substances and the mechanism by which they cause pruritus has not been discerned.
E A, Jones, N V, Bergasa
openaire +3 more sources
Why do patients with cholestasis itch? The answer to this fundamental question is unknown. It is inferred that substances that accumulate in plasma and other tissues, as a result of cholestasis, cause pruritus; however, the specific nature of the substances and the mechanism by which they cause pruritus has not been discerned.
E A, Jones, N V, Bergasa
openaire +3 more sources
Pediatric Clinics of North America, 2017
Neonatal jaundice is common and usually not concerning when it is secondary to unconjugated hyperbilirubinemia, below the neurotoxic level, and resolves early. Primary care providers should be vigilant, however, about evaluating infants in whom jaundice presents early, is prolonged beyond 2 weeks of life, or presents at high levels.
Erin, Lane, Karen F, Murray
openaire +2 more sources
Neonatal jaundice is common and usually not concerning when it is secondary to unconjugated hyperbilirubinemia, below the neurotoxic level, and resolves early. Primary care providers should be vigilant, however, about evaluating infants in whom jaundice presents early, is prolonged beyond 2 weeks of life, or presents at high levels.
Erin, Lane, Karen F, Murray
openaire +2 more sources
The Pathogenesis of Cholestasis
Hospital Practice, 1990How does cholestasis develop when there is no obvious obstruction, destruction, or malformation of bile ducts? Recent findings on bile formation and flow are reviewed, and two models of intrahepatic cholestasis are presented: one of rapid onset, which is bile acid induced, and the other of slow onset, which is estrogen induced.
P, Zimniak, A, Radominska, R, Lester
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Clinics in Liver Disease, 1999
Sepsis-associated cholestasis should always be considered as part of the differential diagnosis of jaundice in the hospitalized or critically ill patient. The development of a disproportionate elevation of serum bilirubin in comparison with serum alkaline phosphatase and serum aminotransferases should be considered an early warning sign of an ...
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Sepsis-associated cholestasis should always be considered as part of the differential diagnosis of jaundice in the hospitalized or critically ill patient. The development of a disproportionate elevation of serum bilirubin in comparison with serum alkaline phosphatase and serum aminotransferases should be considered an early warning sign of an ...
openaire +3 more sources
Pathophysiology of cholestasis
Human Pathology, 1970Abstract Cholestasis is postulated to be a disturbance of the secretion of micelles of bile salts mixed with other solids. This disturbance results in alteration of bile canalicular microvilli, canalicular dilatation, whidening of the pericanalicular ectoplasm, enlargement of the Golgi zone, and increase in smooth endoplasmic reticulum. Cholestasis is
H, Popper, F, Schaffner
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Seminars in Liver Disease, 2004
Hepatic formation of bile is critical to survival and is one of the most easily disrupted liver functions. Liver biopsy is performed to obtain a definitive diagnosis of cause, to exclude potential etiologies, or simply to assist in development of a differential diagnosis. Parenchymal changes of cholestasis (feathery degeneration of hepatocytes, dilated
Melissa K, Li, James M, Crawford
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Hepatic formation of bile is critical to survival and is one of the most easily disrupted liver functions. Liver biopsy is performed to obtain a definitive diagnosis of cause, to exclude potential etiologies, or simply to assist in development of a differential diagnosis. Parenchymal changes of cholestasis (feathery degeneration of hepatocytes, dilated
Melissa K, Li, James M, Crawford
openaire +2 more sources
Obstetrics and Gynecology Clinics of North America, 2010
Intrahepatic cholestasis (ICP) of pregnancy is a disease that is likely multifactorial in etiology and has a prevalence that varies by geography and ethnicity. The diagnosis is made when patients have a combination of pruritus and abnormal liver-function tests.
Bhuvan, Pathak +2 more
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Intrahepatic cholestasis (ICP) of pregnancy is a disease that is likely multifactorial in etiology and has a prevalence that varies by geography and ethnicity. The diagnosis is made when patients have a combination of pruritus and abnormal liver-function tests.
Bhuvan, Pathak +2 more
openaire +2 more sources