Results 21 to 30 of about 113,305 (364)

CHRONIC CHOLESTASIS IN INFANCY [PDF]

Romanian Journal of Pediatrics, 2009
This article focuses on the few disorders that produce chronic cholestasis in infants. The author presents: definition and pathophysiology of cholestasis; the consequences of cholestasis; an approach to diagnosis of cholestasis in infancy and childhood;
Daniela Patrichi
doaj   +1 more source

Neonatal cholestasis as the onset symptom of McCune–Albright syndrome: case reports and a literature review

Frontiers in Pediatrics, 2023
AimThis study aimed to summarize and show the characteristics and evolutionary process of neonatal cholestasis caused by McCune–Albright syndrome (MAS), as neonatal cholestasis may be the initial manifestation of MAS before other classic clinical ...
Weiyuan Fang, Yanhui Zhang, Lian Chen, Xinbao Xie   +3 more
doaj   +1 more source

Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling

Hepatology, 2021
Cholestasis is characterized by increased total bile acid (TBA) levels, which are regulated by farnesoid X receptor (FXR)/FGF15. Patients with primary sclerosing cholangitis (PSC) typically present with inflammatory bowel disease (IBD). Mast cells (MCs) (
Vik Meadows, Lindsey Kennedy, B. Ekser, Konstantina Kyritsi, Debjyoti Kundu, Tianhao Zhou, Lixian Chen, L. Pham, Nan Wu, Jennifer Demieville, Laura A Hargrove, S. Glaser, G. Alpini, H. Francis   +13 more
semanticscholar   +1 more source

A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisAJOG Global Reports at a Glance

AJOG Global Reports, 2021
BACKGROUND: Gestational diabetes and obstetrical cholestasis are common clinical conditions seen in clinical practice. There is evidence suggesting a coexisting relationship that could have a potential clinical implication related to stillbirth outcomes.
Manoj Mohan, MRCOG, Sanjay Swargathmadhom Prabhu, MRCOG, Abdul Kareem Pullattayil, MSIt, Stephen Lindow, FRCOG   +3 more
doaj   +1 more source

Newer variants of progressive familial intrahepatic cholestasis

World Journal of Hepatology, 2021
Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of disorders characterized by defects in bile secretion and presentation with intrahepatic cholestasis in infancy or childhood. The most common types include PFIC 1 (deficiency
Vignesh Vinayagamoorthy, A. Srivastava, M. Sarma   +2 more
semanticscholar   +1 more source

The Pathological Mechanisms of Estrogen-Induced Cholestasis: Current Perspectives

Frontiers in Pharmacology, 2021
Estrogens are steroid hormones with a wide range of biological activities. The excess of estrogens can lead to decreased bile flow, toxic bile acid (BA) accumulation, subsequently causing intrahepatic cholestasis.
Y. Zu, Jin-yu Yang, Chengliang Zhang, Dong Liu   +3 more
semanticscholar   +1 more source

Intrahepatic cholestasis of pregnancy

Canadian Medical Association Journal, 2020
Intrahepatic cholestasis of pregnancy is a liver disorder that occurs in pregnant women. Cholestasis is a condition that impairs the release of a digestive fluid called bile from liver cells.
Sebastian R Hobson, Shital Gandhi, Mara Sobel   +2 more
semanticscholar   +1 more source

Distribution of endotoxin in maternal and fetal body with intrahepatic cholestasis of pregnancy and its association with adverse fetal outcome

BMC Pregnancy and Childbirth, 2022
Background Intrahepatic cholestasis of pregnancy is a pregnancy-specific liver disease. In this study, we sought to explore the distribution of lipopolysaccharide in the maternal body, and its effect on the fetal body in the intrahepatic cholestasis of ...
Xiaomei Huang, Lei Lei, Fan Feng, Yong Shao   +3 more
doaj   +1 more source

Progressive familial intrahepatic cholestasis

Definitions, 2020
Neonatal cholestasis is one of the commonest presentations in the field of pediatric hepatol‐ ogy and gastroenterology and constitutes the major indication for liver transplantation be‐ low two years of age. Unfortunately, in spite of being common, fewer
R. Khanna, V. Gautam
semanticscholar   +1 more source

Cholestasis-Associated Pruritus and Its Pruritogens

Frontiers in Medicine, 2021
Pruritus is a debilitating symptom of various cholestatic disorders, including primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) and inherited progressive familial intrahepatic cholestasis (PFIC). The molecular mechanisms leading to
Jacqueline Langedijk, U. Beuers, R. O. Oude Elferink   +2 more
semanticscholar   +1 more source