Results 51 to 60 of about 113,305 (364)

Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multicenter Observational Study

Hepatology Communications, 2020
Alagille syndrome (ALGS) is an autosomal dominant multisystem disorder with cholestasis as a defining clinical feature. We sought to characterize hepatic outcomes in a molecularly defined cohort of children with ALGS‐related cholestasis.
B. Kamath, W. Ye, N. Goodrich, K. Loomes, R. Romero, J. Heubi, D. Leung, N. Spinner, D. Piccoli, E. Alonso, S. Guthery, S. Karpen, C. Mack, J. Molleston, K. Murray, P. Rosenthal, J. Squires, J. Teckman, Kasper S. Wang, Richard J. Thompson, J. Magee, R. Sokol   +21 more
semanticscholar   +1 more source

Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in earlyand late-stage cholestasis [PDF]

, 2017
AIM: To ascertain whether cholestasis affects the expression of two CYP3A isoforms (CYP3A1 and CYP3A2) and of pregnane X receptor (PXR) and constitutive androstane receptor (CAR).
Albertoni, Laura, Baldo, Vincenzo, Baldovin, Tatjana, Carrara, Maria, DALLA POZZA, Arianna, De Martin, Sara, Floreani, Annarosa, Gabbia, Daniela, Lazzari, Roberta, Zigiotto, Giorgia   +9 more
core   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Effects of cytomegalovirus infection on the differential diagnosis between biliary atresia and intrahepatic cholestasis in a Chinese large cohort study

Annals of Hepatology, 2021
Introduction and objectives: Differentiating biliary atresia from other causes of neonatal cholestasis is challenging, particularly when cytomegalovirus (CMV) and biliary atresia occur simultaneously.
Dongying Zhao, Xiaohui Gong, Yahui Li, Xiaoang Sun, Yan Chen, Zhaohui Deng, Yongjun Zhang   +6 more
doaj   +1 more source

Pathologic analysis of liver transplantation for primary biliary cirrhosis [PDF]

, 1988
A retrospective histopathologic review of all pathologic specimens from 394 adult liver transplant patients was undertaken with clinical correlation to determine if primary biliary cirrhosis has affected the posttrans‐plant course compared to all other ...
Ballardini, Baum, Berg, Bernuau, Demetris, Demetris, Demetris, Demetris, Detre, Epstein, Epstein, Esquivel, Fennell, Fung, Haagsma, Iwatsuki, James, MacSween, McFarlane, McFarlane, Neuberger, Popper, Portmann, Portmann, Portmann, Vento   +25 more
core   +1 more source

Benign recurrent intrahepatic cholestasis

Definitions, 2020
Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodes of liver dysfunction called cholestasis. During these episodes, the liver cells have a reduced ability to release a digestive fluid called bile.
Alexander K. C. Leung, M. Schmitt, Christie P. Thomas, Cord Sunderkötter, M. Schiller, Thomas Schwarz, M. Berneburg, A. Kohlschütter, Lorenzo Cerroni, H. Direşkeneli, Kenneth Calamia, Gloria L. David, D. Zeldin, B. Schütte, Lee A. Denson, Andreas Erhardt, Ralf Kubitz, D. Häussinger, W. Sealey, Donald M. Mock, Barry Wolf, Johannes Schumacher, Peter Propping, D. Metze, Andrew L. Wong, M. Hengstschläger, Whitney A. High, Kenneth R. Shroyer, M. E. Mccready, Dennis E. Bulman, Ali R. Afzal, David B. Everman, C. Stoll, S. Darcan, Y. Kou, You Shuei Lin, Yoichi Suzuki, Keiya Tada, S. Kupka, Wolfgang Dietmaier, Arndt Hartmann, R. Hennekam, J. Belperio, Michael P. Keane, M. Iain Smith, Robert M. Strieter, Nestor A. Molfino, F. Sciandra, T. Rossenbacker, S. Priori, Marco Senzolo, Christos Triantos, Dimitrios Samonakis, E. Cholongitas, A. Burroughs, Marco Mura, Markus Braun-Falco, S. Hofmann, Leena Bruckner‐Tuderman   +58 more
semanticscholar   +1 more source

Discriminating Different Classes of Toxicants by Transcript Profiling [PDF]

, 2004
Male rats were treated with various model compounds or the appropriate vehicle controls. Most substances were either well-known hepatotoxicants or showed hepatotoxicity during preclinical testing.
Albertini, Silvio, Boess, Franziska, de Vera, Maria Cristina, Gasser, Rodolfo, Ruepp, Stefan, Steiner, Guido, Suter, Laura   +6 more
core   +2 more sources

Compound Heterozygous MYO5B Mutation, a Cause of Infantile Cholestasis: A Case Report

Journal of Nepal Medical Association, 2022
Infantile cholestasis is a common clinical problem in early infancy characterised by impairment in bile formation and/or flow. It requires prompt evaluation for underlying aetiology to initiate appropriate management.
Muna Khanal, Adarsh Kumar Jha, Arun Kumar Sharma   +2 more
doaj   +1 more source

A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis. [PDF]

, 2019
Primary biliary cholangitis (PBC) is typically associated with elevated serum bile acid levels and pruritus, but pruritus is often refractory to treatment with existing therapies.
Apostol, George, Bacon, Bruce, Bowlus, Christopher L, Dorenbaum, Alejandro, Gu, Joan, Hirschfield, Gideon M, Jones, David, Kennedy, Ciara, Levy, Cynthia, Luketic, Velimir, Mayo, Marlyn J, Medendorp, Sharon, Novak, Patricia, Patanwala, Imran, Pockros, Paul J, Vuppalanchi, Raj   +15 more
core   +2 more sources

Urinary porphyrin excretion in hepatitis C infection [PDF]

, 1999
A high prevalence of hepatitis C virus infection in porphyria cutanea tarda in some populations suggests a close link between viral hepatitis and alteration of porphyrin metabolism.
Jacob, Karl, Vogeser, Michael, Zachoval, Reinhart   +2 more
core   +1 more source