Results 1 to 10 of about 15,107 (222)
Menin-MLL inhibitors as a new therapeutic target for middle ear cholesteatoma [PDF]
Scientific ReportsMiddle ear cholesteatoma (cholesteatoma), also known as a cholesteatomatous chronic otitis media, is concerning because it expands into the middle ear with bone destruction and causes irreversible hearing loss.
Tomomi Yamamoto-Fukuda +2 more
doaj +2 more sources
European Annals of Otorhinolaryngology, Head and Neck Diseases, 2010 Although cholesteatoma was first described in 1683, its etiopathogeny remains unexplained. In children, there are two forms: acquired cholesteatoma, resembling the adult form, and congenital cholesteatoma. The acquired form has become less frequent in recent years, thanks to progress in the treatment of childhood otitic pathology.
Nevoux, J. +5 more
exaly +3 more sources
Identification of altered protein abundances in cholesteatoma matrix via mass spectrometry-based proteomic analysis [PDF]
Journal of Otolaryngology - Head and Neck Surgery, 2015 Background Cholesteatoma are cyst-like structures lined with a matrix of differentiated squamous epithelium overlying connective tissue. Although epithelium normally exhibits self-limited growth, cholesteatoma matrix erodes mucosa and bone suggesting ...
Derrick R. Randall +2 more
doaj +2 more sources
The significance of the expression of cell proliferation and inflammation markers in the development of acquired middle ear cholesteatoma [PDF]
Vojnosanitetski Pregled, 2018 Background/Aim. Permanent proliferation and periodical infection are the main clinical characteristics of acquired middle ear cholesteatoma. The aim of this study was to research immunohistochemical characteristics of the skin along with the ...
Erdoglija Milan +5 more
doaj +1 more source
Use of artificial intelligence for the diagnosis of cholesteatoma
Laryngoscope Investigative Otolaryngology, 2023 Objectives Accurate diagnosis of cholesteatomas is crucial. However, cholesteatomas can easily be missed in routine otoscopic exams. Convolutional neural networks (CNNs) have performed well in medical image classification, so we evaluated their use for ...
Christopher C. Tseng +2 more
doaj +1 more source
Establishment and Characterization of an Model for Cholesteatoma [PDF]
Clinical and Experimental Otorhinolaryngology, 2008 ObjectivesExperimental models are of importance to study the pathogenesis of middle ear cholesteatoma, however, they were not established until now.
Alexander M. Raynov +4 more
doaj +1 more source
Cholesteatoma and family history: An international survey [PDF]
, 2020 Objective To explore the relative frequency of a family history of cholesteatoma in patients with known cholesteatoma, and whether bilateral disease or earlier diagnosis is more likely in those with a family history.
Clark, Allan +6 more
core +1 more source
Congenital cholesteatoma [PDF]
Current Opinion in Otolaryngology & Head and Neck Surgery, 2004 Congenital cholesteatomas have historically been considered a rare disorder. However, a review of the literature reveals an incidence ranging from 4 to 24%, and these values are probably underestimated. This article summarizes the general diagnostic criteria of congenital cholesteatomas, their usual presenting symptoms and findings, perioperative ...
Ken, Kazahaya, William P, Potsic
openaire +4 more sources
BioMedical Engineering OnLine, 2021 Background Middle ear cholesteatoma is characterized by hyper-proliferation of keratinocytes. Circular RNA (circRNA) plays an essential role in the pathogenesis of many proliferative diseases.
Shumin Xie +4 more
doaj +1 more source
Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity [PDF]
Clinical and Experimental Otorhinolaryngology, 2017 Objectives Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity.
Mahmood A. Hamed +11 more
doaj +1 more source