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European Annals of Otorhinolaryngology, Head and Neck Diseases, 2010 Although cholesteatoma was first described in 1683, its etiopathogeny remains unexplained. In children, there are two forms: acquired cholesteatoma, resembling the adult form, and congenital cholesteatoma. The acquired form has become less frequent in recent years, thanks to progress in the treatment of childhood otitic pathology.
Jérôme Nevoux +2 more
exaly +3 more sources
Menin-MLL inhibitors as a new therapeutic target for middle ear cholesteatoma [PDF]
Scientific ReportsMiddle ear cholesteatoma (cholesteatoma), also known as a cholesteatomatous chronic otitis media, is concerning because it expands into the middle ear with bone destruction and causes irreversible hearing loss.
Tomomi Yamamoto-Fukuda +2 more
doaj +2 more sources
Mesna in Otologic Surgery: Efficacy and Safety-A Scoping Review. [PDF]
LaryngoscopePRISMA flow diagram indicating the process of systematic inclusion and exclusion of articles. ABSTRACT Objective Mesna (Sodium 2‐mercaptoethanesulfonate) is widely used as a mucolytic agent and uroprotective agent. Recently, its disulfide bond‐breaking property has been applied in otologic surgery to facilitate safer dissection of cholesteatoma and ...
Atamian KH +4 more
europepmc +2 more sources
Mastoid Surgery Does Not Normalize Tympanometric Middle Ear Pressure in Children With Cholesteatoma. [PDF]
LaryngoscopeConflicting mechanism‐based hypotheses have been used to promote selection of different approaches to management of the mastoid in order to optimize middle ear pressure homeostasis after removal of cholesteatoma. For example: (a) conservation of mastoid mucosa and opening of ventilation pathways endoscopically to normalize function, (b) removal of ...
James AL.
europepmc +2 more sources
The significance of the expression of cell proliferation and inflammation markers in the development of acquired middle ear cholesteatoma [PDF]
Vojnosanitetski Pregled, 2018 Background/Aim. Permanent proliferation and periodical infection are the main clinical characteristics of acquired middle ear cholesteatoma. The aim of this study was to research immunohistochemical characteristics of the skin along with the ...
Erdoglija Milan +5 more
doaj +1 more source
Establishment and Characterization of an Model for Cholesteatoma [PDF]
Clinical and Experimental Otorhinolaryngology, 2008 ObjectivesExperimental models are of importance to study the pathogenesis of middle ear cholesteatoma, however, they were not established until now.
Alexander M. Raynov +4 more
doaj +1 more source
Use of artificial intelligence for the diagnosis of cholesteatoma
Laryngoscope Investigative Otolaryngology, 2023 Objectives Accurate diagnosis of cholesteatomas is crucial. However, cholesteatomas can easily be missed in routine otoscopic exams. Convolutional neural networks (CNNs) have performed well in medical image classification, so we evaluated their use for ...
Christopher C. Tseng +2 more
doaj +1 more source
BioMedical Engineering OnLine, 2021 Background Middle ear cholesteatoma is characterized by hyper-proliferation of keratinocytes. Circular RNA (circRNA) plays an essential role in the pathogenesis of many proliferative diseases.
Shumin Xie +4 more
doaj +1 more source
Cytokeratin 13, Cytokeratin 17, and Ki-67 Expression in Human Acquired Cholesteatoma and Their Correlation With Its Destructive Capacity [PDF]
Clinical and Experimental Otorhinolaryngology, 2017 Objectives Cholesteatoma is a nonneoplastic destructive lesion of the temporal bone with debated pathogenesis and bone resorptive mechanism. Both molecular and cellular events chiefly master its activity.
Mahmood A. Hamed +11 more
doaj +1 more source
Philippine Journal of Otolaryngology Head and Neck Surgery, 2021 Objective: To determine the stage of middle ear cholesteatoma of patients who underwent middle ear surgery at the Southern Philippines Medical Center from January to December 2019, based on European Academy of Otology and Neurotology / Japan ...
Dominador Toral, Chris Robinson Laganao
doaj +1 more source