Results 1 to 10 of about 13,754 (204)

Menin-MLL inhibitors as a new therapeutic target for middle ear cholesteatoma [PDF]

Scientific Reports
Middle ear cholesteatoma (cholesteatoma), also known as a cholesteatomatous chronic otitis media, is concerning because it expands into the middle ear with bone destruction and causes irreversible hearing loss.
Tomomi Yamamoto-Fukuda, Naotaro Akiyama, Hiromi Kojima   +2 more
doaj   +2 more sources

The Global Burden of Cholesteatoma: A Systematic Review and Meta-analysis. [PDF]

Otolaryngol Head Neck Surg
Abstract Objective This systematic review and meta‐analysis sought to estimate the global and World Health Organization (WHO) regional prevalence and burden of cholesteatoma. Data Sources PubMed, APA PsycINFO, the Cochrane Library, Embase, and WHO International Clinical Trials Registry Platform (ICTRP) from 2010 to 2025.
Melariri H, Balakrishna Y, Mukhtar A, Joseph E, Labuschagne S, Hapunda-Chibanga R, Finestone S, Bosman A, Ukaegbe O, Werkineh HB, Merven M, Seguya A, Melariri B, Mokoh L, Els T, Tharratt D, Murtaza A, Moosajee M, Harris T, Onotai L, Amir I, Melariri P.   +21 more
europepmc   +2 more sources

HMGB1 Carried by Small Extracellular Vesicles Potentially Plays a Role in Promoting Acquired Middle Ear Cholesteatoma [PDF]

Diagnostics, 2023
Cholesteatoma is a specific medical condition involving the abnormal, non-cancerous growth of skin-like tissue in the middle ear, potentially leading to a collection of debris and even infections. The receptor for advanced glycation (RAGE) and its ligand,
Michał W. Łuczak, Karolina Dżaman, Łukasz Zaręba, Katarzyna Czerwaty, Jacek Siewiera, Alicja Głuszko, Ewa Olszewska, Jacek Brzost, Ireneusz Kantor, Mirosław J. Szczepański, Nils Ludwig   +10 more
doaj   +2 more sources

Increased Risk of Cholesteatoma in Individuals With Alpha-1 Antitrypsin Deficiency: A Cohort Study. [PDF]

Laryngoscope
Patients with AATD had a 3.6‐fold increased risk of cholesteatoma surgery (HR: 3.62) compared to controls. These findings suggest that AATD may contribute to the development of cholesteatoma. ABSTRACT Objective To estimate the risk of cholesteatoma in patients with alpha‐1 antitrypsin deficiency (AATD) compared to the general population using time‐to ...
Ali A, Ravn HA, Dahl M, Djurhuus BD.
europepmc   +2 more sources

Quantitative Analysis of Cochlear-Carotid Recesses Based on HRCT in Endoscope-Assisted Management of Massive Petrous Bone Cholesteatoma. [PDF]

J Otolaryngol Head Neck Surg
Ma MY, Gao Z, Li FT, Zhang WX, Jia XH, Yuan YS.   +5 more
europepmc   +2 more sources

The significance of the expression of cell proliferation and inflammation markers in the development of acquired middle ear cholesteatoma [PDF]

Vojnosanitetski Pregled, 2018
Background/Aim. Permanent proliferation and periodical infection are the main clinical characteristics of acquired middle ear cholesteatoma. The aim of this study was to research immunohistochemical characteristics of the skin along with the ...
Erdoglija Milan, Grgurević Uglješa, Cerović Snežana, Jović Milena, Baletić Nenad, Sotirović Jelena   +5 more
doaj   +1 more source

Use of artificial intelligence for the diagnosis of cholesteatoma

Laryngoscope Investigative Otolaryngology, 2023
Objectives Accurate diagnosis of cholesteatomas is crucial. However, cholesteatomas can easily be missed in routine otoscopic exams. Convolutional neural networks (CNNs) have performed well in medical image classification, so we evaluated their use for ...
Christopher C. Tseng, Valerie Lim, Robert W. Jyung   +2 more
doaj   +1 more source

Establishment and Characterization of an Model for Cholesteatoma [PDF]

Clinical and Experimental Otorhinolaryngology, 2008
ObjectivesExperimental models are of importance to study the pathogenesis of middle ear cholesteatoma, however, they were not established until now.
Alexander M. Raynov, Yun-Hoon Choung, Hun Yi Park, Seong Jun Choi, Keehyun Park   +4 more
doaj   +1 more source

Congenital cholesteatoma [PDF]

Current Opinion in Otolaryngology & Head and Neck Surgery, 2004
Congenital cholesteatomas have historically been considered a rare disorder. However, a review of the literature reveals an incidence ranging from 4 to 24%, and these values are probably underestimated. This article summarizes the general diagnostic criteria of congenital cholesteatomas, their usual presenting symptoms and findings, perioperative ...
Ken, Kazahaya, William P, Potsic
openaire   +4 more sources

Classification and Stages of Middle Ear Cholesteatoma at the Southern Philippines Medical Center Using the European Academy of Otology and Neurotology / Japan Otological Society (EAONO / JOS) System

Philippine Journal of Otolaryngology Head and Neck Surgery, 2021
Objective: To determine the stage of middle ear cholesteatoma of patients who underwent middle ear surgery at the Southern Philippines Medical Center from January to December 2019, based on European Academy of Otology and Neurotology / Japan ...
Dominador Toral, Chris Robinson Laganao
doaj   +1 more source