Menin-MLL inhibitors as a new therapeutic target for middle ear cholesteatoma [PDF]
Scientific ReportsMiddle ear cholesteatoma (cholesteatoma), also known as a cholesteatomatous chronic otitis media, is concerning because it expands into the middle ear with bone destruction and causes irreversible hearing loss.
Tomomi Yamamoto-Fukuda +2 more
doaj +2 more sources
Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanism
Cell Communication and Signaling, 2021 Background Cholesteatoma disease is an expanding lesion in the middle ear. Hearing loss and facial paralysis alongside with other intracranial complications are found.
Matthias Schürmann +7 more
doaj +2 more sources
Transcanal Endoscopic Ear Surgery for Congenital Cholesteatoma [PDF]
Clinical and Experimental Otorhinolaryngology, 2018 Objectives As endoscopic instrumentation, techniques and knowledges have significantly improved recently, endoscopic ear surgery has become increasingly popular. Transcanal endoscopic ear surgery (TEES) can provide better visualization of hidden areas in
Joo Hyun Park, Jungmin Ahn, Il Joon Moon
doaj +2 more sources
The genetics of cholesteatoma. A systematic review using narrative synthesis [PDF]
Clinical Otolaryngology, 2018 Objective: A cholesteatoma is a mass of keratinising epithelium in the middle ear. It is a rare disorder that is associated with significant morbidity, and its causative risk factors are poorly understood; on a global scale up to a million people are ...
Al Balushi +51 more
core +2 more sources
Recurrence in cholesteatoma surgery: what have we learnt and where are we going? A narrative review
Acta otorhinolaryngologica italica, 2023 SUMMARY Treatment of cholesteatoma is surgical and has historically encompassed two main techniques: canal wall up (CWU) and canal wall down (CWD) tympanoplasty.
Chiara Bovi +5 more
semanticscholar +1 more source
JAMA Otolaryngology - Head and Neck Surgery, 2023 Key Points Question Is cholesteatoma in a first-degree relative associated with an increased risk of the disease? Findings In this nationwide case-control study of first-time cholesteatoma surgeries including 10 618 cases and 21 235 controls in Sweden ...
Åsa Bonnard +6 more
semanticscholar +1 more source
The significance of the expression of cell proliferation and inflammation markers in the development of acquired middle ear cholesteatoma [PDF]
Vojnosanitetski Pregled, 2018 Background/Aim. Permanent proliferation and periodical infection are the main clinical characteristics of acquired middle ear cholesteatoma. The aim of this study was to research immunohistochemical characteristics of the skin along with the ...
Erdoglija Milan +5 more
doaj +1 more source
Use of artificial intelligence for the diagnosis of cholesteatoma
Laryngoscope Investigative Otolaryngology, 2023 Objectives Accurate diagnosis of cholesteatomas is crucial. However, cholesteatomas can easily be missed in routine otoscopic exams. Convolutional neural networks (CNNs) have performed well in medical image classification, so we evaluated their use for ...
Christopher C. Tseng +2 more
doaj +1 more source
Establishment and Characterization of an Model for Cholesteatoma [PDF]
Clinical and Experimental Otorhinolaryngology, 2008 ObjectivesExperimental models are of importance to study the pathogenesis of middle ear cholesteatoma, however, they were not established until now.
Alexander M. Raynov +4 more
doaj +1 more source
Early non-EPI DW-MRI after cholesteatoma surgery
Ear, nose, & throat journal, 2021 Objective Middle ear cholesteatoma may lead to the erosion of the bony structures of the temporal bone, possibly causing intra- and extracranial complications.
M. Barbara +9 more
semanticscholar +1 more source