Results 221 to 230 of about 2,770,733 (305)

Association of rs2000999 in the haptoglobin gene with total cholesterol, HDL-C, and LDL-C levels in Mexican type 2 diabetes patients. [PDF]

Medicine (Baltimore), 2019
Suarez-Sanchez F, Vazquez-Moreno M, Herrera-Lopez E, Gomez-Zamudio JH, Peralta-Romero JJ, Castelan-Martinez OD, Cruz M, Parra EJ, Valladares-Salgado A.   +8 more
europepmc   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Predictive value of non-high-density lipoprotein cholesterol and remnant cholesterol for progression of non-culprit coronary lesions with QFR ≤ 0.80: A retrospective cohort study. [PDF]

Medicine (Baltimore)
Ruan G, Guan Q, Li J, Li G, Ren H.
europepmc   +1 more source

Bell's Palsy in 11,255 Cases: Cardiometabolic Associations in a Population‐Based Healthcare Database

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To estimate Bell's palsy incidence and evaluate the prevalence and associations with diabetes and other cardiometabolic conditions. Study Design Population‐based cohort study. Setting Clalit Health Services, the largest healthcare provider organization in Israel (2005‐2022).
Tomer Boldes, Ori Cohen Michael, Ortal Fallek Boldes, Firas Kassem, Benny Nageris, Ameen Biadsee   +5 more
wiley   +1 more source

Regulatory Bottlenecks Linking HDL Dysfunction, Inflammation, and Oxidative Stress: A Petri Net-Based Systems Analysis. [PDF]

Int J Mol Sci
Formanowicz D, Rynkiewicz AA, Formanowicz P.   +2 more
europepmc   +1 more source

The role of tryptophan hydroxylase‐1 in metabolic dysfunction‐associated steatotic liver disease

Pediatric Investigation, EarlyView.
Silencing hepatic tryptophan hydroxylase 1 (TPH1) alleviated diet‐induced steatotic liver disease by reducing lipid accumulation, oxidative stress, inflammation, fibrosis, and hepatocyte apoptosis. These protective effects were mediated, at least in part, through restoration of Parkin‐dependent mitochondrial autophagy, identifying hepatic TPH1 as a ...
Shuangzhen Jia, Xiaolin Ye, Zhaoxia Wang, Jie Wu   +3 more
wiley   +1 more source

Tangier Disease. [PDF]

Curr Atheroscler Rep
Sasidharan Pillai S, Brar PC, Ashraf AP.
europepmc   +1 more source

Recompensation of Cirrhosis: A New Treatment‐Related Disease State

Portal Hypertension &Cirrhosis, EarlyView.
This perspective article conceptualizes recompensation of cirrhosis as a distinct treatment‐related disease state rather than mere transient clinical improvement after etiology‐directed therapy, and further proposes a four‐state classification including compensated cirrhosis, stable recompensation, unstable recompensation, and persistent decompensation
Wentao Tan, Zhiying He, Shuai Xia, Luqi Tang, Hong You, Bingqiong Wang   +5 more
wiley   +1 more source

Associations of plasma HDL subclasses with incident dementia risk in older adults. [PDF]

Alzheimers Dement
An B, Ali S, Smith K, Roemhild S, Neumann L, Stoll DR, Li L, Lutsey PL, Mielke MM, Yu F, Hoogeveen RC, Zhang L, Alonso A, Li D.   +13 more
europepmc   +1 more source

Modeling of Disease Progression of Type 2 Diabetes Using Real‐World Data: Quantifying Competing Risks of Morbidity and Mortality

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 606-615, March 2025.
ABSTRACT Type 2 diabetes (T2D) is a progressive metabolic disorder that could be an underlying cause of long‐term complications that increase mortality. The assessment of the probability of such events could be essential for mortality risk management. This work aimed to establish a framework for risk predictions of macrovascular complications (MVC) and
Hanna Kunina, Stefan Franzén, Maria C. Kjellsson   +2 more
wiley   +1 more source