Results 21 to 30 of about 882,729 (197)
Journal of Lipid Research, 1990 The effects of dietary cholesterol and fatty acids on the plasma cholesterol level and rates of very low density lipoprotein (VLDL) cholesterol secretion and low density lipoprotein (LDL) transport through LDL receptors in the liver of the hamster were ...
H Ohtani +8 more
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Journal of Lipid Research, 2007 Endocytosis of LDL and modified LDL represents regulated and unregulated cholesterol delivery to macrophages. To elucidate the mechanisms of cellular cholesterol transport and egress under both conditions, various primary macrophages were labeled and ...
Ming-Dong Wang +5 more
doaj +1 more source
Existing and emerging therapies for the treatment of familial hypercholesterolemia
Journal of Lipid Research, 2021 Familial hypercholesterolemia (FH), an autosomal dominant disorder of LDL metabolism that is characterized by elevated LDL-cholesterol, is commonly encountered in patients with atherosclerotic coronary heart disease.
Robert S. Rosenson
doaj +1 more source
Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.
New England Journal of Medicine, 2020 BACKGROUND Inclisiran inhibits hepatic synthesis of proprotein convertase subtilisin-kexin type 9. Previous studies suggest that inclisiran might provide sustained reductions in low-density lipoprotein (LDL) cholesterol levels with infrequent dosing ...
K. Ray +10 more
semanticscholar +1 more source
Detection of quantitative trait loci affecting serum cholesterol, LDL, HDL, and triglyceride in pigs [PDF]
BMC Genetics, 2011 AbstractBackgroundSerum lipids are associated with many serious cardiovascular diseases and obesity problems. Many quantitative trait loci (QTL) have been reported in the pig mostly for performance traits but very few for the serum lipid traits. In contrast, remarkable numbers of QTL are mapped for serum lipids in humans and mice.
Uddin, Muhammad Jasim +7 more
openaire +7 more sources
Journal of Lipid Research, 1989 The rate of degradation of oxidatively modified low density lipoprotein (Ox-LDL) by human endothelial cells was similar to that of unmodified low density lipoprotein (LDL), and was approximately 2-fold greater than the rate of degradation of acetylated ...
I Jialal, A Chait
doaj +1 more source
Journal of Lipid Research, 2000 Oxidized low density lipoprotein (LDL) has been found to exhibit numerous potentially atherogenic properties, including transformation of macrophages to foam cells.
Baljinder S. Dhaliwal +1 more
doaj +1 more source
Cardiovascular Diabetology, 2023 Background Dyslipidemia measured as low-density lipoprotein (LDL)-cholesterol is an established risk factor of cardiovascular disease, which is more pronounced in diabetes population.
Yun Gi Kim +9 more
doaj +1 more source
The Relationship Between Childhood BMI and Adult Serum Cholesterol, LDL, and Ankle Brachial Index [PDF]
Clinical Medicine & Research, 2014 Effects of childhood overweight may persist into adulthood. We assessed the effect of childhood overweight on cardiovascular disease high risk factor levels in the same participants as adults, after controlling for adult body mass index (BMI) status.A subset of participants in an observational study (Heartwatch) were contacted approximately 26-27 years
M E, Sundaram +3 more
openaire +2 more sources
Time Course of LDL Cholesterol Exposure and Cardiovascular Disease Event Risk.
Journal of the American College of Cardiology, 2020 BACKGROUND Incident cardiovascular disease (CVD) increases with increasing low-density lipoprotein cholesterol (LDL-C) concentration and exposure duration. Area under the LDL-C versus age curve is a possible risk parameter.
M. Domanski +14 more
semanticscholar +1 more source