Results 71 to 80 of about 882,729 (197)

Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study

British medical journal, 2017
Objective To test the hypothesis that low density lipoprotein (LDL) cholesterol due to genetic variation in the genes responsible for LDL cholesterol metabolism and biosynthesis(PCSK9 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), respectively) is
M. Benn, B. Nordestgaard, R. Frikke-Schmidt, A. Tybjærg-Hansen   +3 more
semanticscholar   +1 more source

J-shaped association between LDL cholesterol and cardiovascular events: A longitudinal primary prevention cohort of over 2.4 million people nationwide

Journal of Advanced Research
Introduction: Low-density lipoprotein (LDL) cholesterol-lowering treatment is beneficial for the secondary or primary prevention of high-risk atherosclerotic cardiovascular disease (ASCVD).
Chan Soon Park, Han-Mo Yang, Kyungdo Han, Hee-Sun Lee, Jeehoon Kang, Jung-Kyu Han, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim   +9 more
doaj   +1 more source

Effects of age, gender, and menopausal status on plasma low density lipoprotein cholesterol and apolipoprotein B levels in the Framingham Offspring Study.

Journal of Lipid Research, 1994
Plasma low density lipoprotein (LDL) cholesterol, non-high density lipoprotein (HDL) cholesterol, and apolipoprotein (apo) B, the major protein constituent of LDL, were measured in 1,533 men (mean age 49 +/- 10 years) and 1,597 women (mean age 49 +/- 10 ...
E J Schaefer, S Lamon-Fava, S D Cohn, M M Schaefer, J M Ordovas, W P Castelli, P W Wilson   +6 more
doaj   +1 more source

Plasma Low-Density Lipoprotein Cholesterol Correlates With Heart Function in Individuals With Type 2 Diabetes Mellitus: A Cross-Sectional Study

Frontiers in Endocrinology, 2019
Background: Heart failure is a frequent complication of type 2 diabetes mellitus (T2DM). Plasma cholesterol, particularly the proatherogenic low-density lipoprotein (LDL) cholesterol, impairs heart function by promoting atheroma formation and ventricular
Po-Chung Cheng, Shang-Ren Hsu, Jung-Chi Li, Ching-Pei Chen, Szu-Chi Chien, Shih-Te Tu, Yun-Chung Cheng, Yu-Hsiu Liu, Jeng-Fu Kuo   +8 more
doaj   +1 more source

Incorporating a Genetic Risk Score into Coronary Heart Disease Risk Estimates: Effect on LDL Cholesterol Levels (the MIGENES Clinical Trial)

Circulation, 2016
Background Whether knowledge of genetic risk for coronary heart disease (CHD) affects health-related outcomes is unknown. We investigated whether incorporating a genetic risk score (GRS) in CHD risk estimates lowers low-density lipoprotein cholesterol ...
I. Kullo, H. Jouni, Erin Austin, Sherry‐Ann Brown, Teresa M Kruisselbrink, I. Isseh, Raad A. Haddad, Tariq S. Marroush, K. Shameer, J. Olson, U. Broeckel, R. Green, D. Schaid, V. Montori, K. Bailey   +14 more
semanticscholar   +1 more source

Quo vadis, LDL cholesterol?

Advances in Laboratory Medicine, 2023
Cobos Andrés, Valdivielso Pedro
doaj   +1 more source

Dependence on dietary cholesterol for n-3 polyunsaturated fatty acid-induced changes in plasma cholesterol in the Syrian hamster.

Journal of Lipid Research, 1992
Male Syrian hamsters consumed diets containing incremental increases in dietary n-3 fatty acids from fish oil with either low (0.015% w/w) or moderate (0.1% w/w) dietary cholesterol content.
ME Surette, J Whelan, GP Lu, KS Broughton, JE Kinsella   +4 more
doaj   +1 more source

Treatment with ETC-1002 alone and in combination with ezetimibe lowers LDL cholesterol in hypercholesterolemic patients with or without statin intolerance.

Journal of Clinical Lipidology, 2016
BACKGROUND ETC-1002 is an oral, once-daily, first-in-class medication being developed to treat hypercholesterolemia. OBJECTIVES To compare 2 doses of ETC-1002, alone or combined with ezetimibe 10 mg (EZE), vs EZE monotherapy for lowering low-density ...
P. Thompson, D. Macdougall, R. Newton, J. Margulies, J. Hanselman, D. Orloff, J. Mckenney, C. Ballantyne   +7 more
semanticscholar   +1 more source

Effects of lipoprotein lipase and statins on cholesterol uptake into heart and skeletal muscles⃞

Journal of Lipid Research, 2007
Regulation of cholesterol metabolism in cultured cells and in the liver is dependent on actions of the LDL receptor. However, nonhepatic tissues have multiple pathways of cholesterol uptake.
Masayoshi Yokoyama, Toru Seo, Taesik Park, Hiroaki Yagyu, Yunying Hu, Ni Huiping Son, Ayanna S. Augustus, Reeba K. Vikramadithyan, Rajasekhar Ramakrishnan, Leslie K. Pulawa, Robert H. Eckel, Ira J. Goldberg   +11 more
doaj   +1 more source

Discordance Between Apolipoprotein B and LDL-Cholesterol in Young Adults Predicts Coronary Artery Calcification: The CARDIA Study

Journal of the American College of Cardiology, 2016
BACKGROUND: High levels of apolipoprotein B (apoB) have been shown to predict atherosclerotic cardiovascular disease (CVD) in adults even in the context of low levels of low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein ...
J. Wilkins, Ron C. Li, A. Sniderman, Cheeling Chan, D. Lloyd-Jones   +4 more
semanticscholar   +1 more source