Results 131 to 140 of about 1,976,779 (394)

ER-lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signaling in Niemann-Pick type C

Nature Cell Biology, 2019
Cholesterol activates the master growth regulator, mTORC1 kinase, by promoting its recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases).
Chun-Yan Lim, Oliver B. Davis, Hijai R. Shin, Justin Zhang, Charles A. Berdan, Xuntian Jiang, Jessica L. Counihan, D. Ory, Daniel K. Nomura, R. Zoncu   +9 more
semanticscholar   +1 more source

Virtual or In‐Person: Does It Matter? Comparing Pain, Function, Quality of Life, Self‐Efficacy, and Physical Function Outcomes of Virtual, Hybrid, and In‐Person Education and Exercise Program Participants

Arthritis Care &Research, EarlyView.
Objective This study aimed to determine if program format (in‐person, virtual, or hybrid) results in differences in 3‐month outcomes of pain, function, quality of life, self‐efficacy, and chair stands in a hip/knee osteoarthritis‐management program. Methods A secondary analysis of the Good Life with osteoArthritis in Denmark (GLA:D) Canada database was
Jill Van Damme, Vanina Dal Bello‐Haas, Ayse Kuspinar, Patricia Strachan, Michael Zywiel, James Young, Rhona McGlasson, Lisa C. Carlesso   +7 more
wiley   +1 more source

Nonlinear relationship between serum 25-hydroxyvitamin D and lipid profile in Chinese adults

Frontiers in Nutrition
BackgroundPrevious studies on the liner associations between serum 25-hydroxyvitamin D [25(OH)D] levels and lipid profiles revealed ambiguous findings.
Qianqian Wang, Qianqian Wang, Xinlei Miao, Manling Hu, Fei Xu, Guimin Tang, Yangxuan He, Ziping Song, Wan Zhao, Xiangjun Niu, Song Leng, Song Leng   +11 more
doaj   +1 more source

Genetic Variation in FADS Genes and Plasma Cholesterol Levels in 2-Year-Old Infants [PDF]

, 2013
Single nucleotide polymorphisms (SNPs) in genes involved in fatty acid metabolism (FADS1 FADS2 gene cluster) are associated with plasma lipid levels. We aimed to investigate whether these associations are already present early in life and compare the ...
Heinrich, Joachim, Jansen, Eugène, Koppelman, Gerard H., Mensink, Ronald P., Moltó-Puigmartí, Carolina, Mommers, Monique, Penders, John, Plat, Jogchum, Postma, Dirkje S., Standl, Marie, Thijs, Carel   +10 more
core   +1 more source

Response to allopurinol and febuxostat according to the fractional excretion of urate in men with gout

Arthritis Care &Research, Accepted Article.
Background Body mass index (BMI), glomerular filtration rate (GFR), and pretreatment urate levels have been reported to influence the urate‐lowering response to allopurinol. We investigated whether the fractional excretion of urate (FEUA) also modulates this response and relates to oxypurinol concentrations. We further evaluated its potential influence
Pascal Richette, Anouk Walter‐Petrich, Quang Dinh Nguyen, Matthieu Resche‐Rigon, Quang Huy Dinh Nguyen, Minh Duc Do, Thao Phuong Mai, Tuan Duc Nguyen, Fernando Perez‐Ruiz, Emmanuel Letavernier, Tristan Pascart, Augustin Latourte, Hang Korng Ea, Thomas Bardin   +13 more
wiley   +1 more source

Serum lipid profiles in acute myocardial infarction patients in Gorgan [PDF]

, 2012
Acute myocardial infarction is one of the important reasons of death and unhealthiness in the world. The present study was undertaken to investigate the changes in serum lipids and lipoproteins in patients with acute myocardial infarction. This study was
Marjani, A., Shirafkan, A., Zaker, F.
core  

Charge-induced phase separation in lipid membranes [PDF]

, 2014
The phase separation in lipid bilayers that include negatively charged lipids is examined experimentally. We observed phase-separated structures and determined the membrane miscibility temperatures in several binary and ternary lipid mixtures of ...
Andelman, David, Hamada, Tsutomu, Himeno, Hiroki, Komura, Shigeyuki, Shimokawa, Naofumi, Takagi, Masahiro   +5 more
core   +2 more sources

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study [PDF]

, 2013
Philippa J. Talmud, Sonia Shah, Ros Whittall, Marta Futema, Philip Howard, Jackie A. Cooper, Seamus C. Harrison, KaWah Li, Fotios Drenos, Fredrik Karpe, H. A. W. Neil, Olivier Descamps, Claudia Langenberg, Nicholas Lench, Mika Kivimäki, John C. Whittaker, Aroon D. Hingorani, Meena Kumari, Steve E. Humphries   +18 more
openalex   +1 more source

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

Nature Communications, 2019
Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER) is essential for cholesterol homoeostasis, but the mechanism and regulation of this transport remains poorly defined.
Doris Höglinger, Doris Höglinger, T. Burgoyne, Elena Sánchez-Heras, P. Hartwig, Alexandria Colaco, Jason C. Newton, C. Futter, S. Spiegel, F. Platt, Emily R. Eden   +10 more
semanticscholar   +1 more source

Infrared Neural Stimulation Elicits Distinct Molecular Pathways in Astrocytes Based on Laser Pulse Parameters

Advanced Biology, EarlyView.
Infrared (IR) light evokes distinct calcium and water transport responses in astrocytes, depending on stimulation duration and protocol. This study uses widefield imaging and pharmacology to reveal differential engagement of astroglial signaling pathways.
Wilson R. Adams, Ana I Borrachero‐Conejo, Pratheepa Kumari Rasiah, Emanuela Saracino, Roberto Zamboni, Eric Duco Jansen, Valentina Benfenati, Anita Mahadevan‐Jansen   +7 more
wiley   +1 more source