Results 141 to 150 of about 1,474,337 (344)

The Influence of Lipid Electric Charge on the Binding of Aβ(1–42) Amyloid Peptide to Bilayers in the Liquid-Ordered State

Biomolecules
The amyloidogenic Aβ peptides are widely considered as a pathogenic agent in Alzheimer’s disease. Aβ(1-42) would form aggregates of amyloid fibrils on the neuron plasma membranes, thus perturbing neuronal functionality.
Hasna Ahyayauch, Massimo E. Masserini, Félix M. Goñi, Alicia Alonso   +3 more
doaj   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Lipid metabolism in overweight/obese children vs. normal weight children in a north-eastern region of Spain

Advances in Laboratory Medicine
Obesity and overweight have increased in children and adolescents in Europe in the recent years, accounting for a major global public health problem.
Cuenca Alcocel José, Villalba-Heredia Lorena, Martínez Redondo Inés, Gallego Royo Alba, Casajús José A., Arbonés-Mainar José M., Calmarza Pilar   +6 more
doaj   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

Fundamentals of lipoprotein(a) request and quantification in the clinical laboratory

Advances in Laboratory Medicine
Cardiovascular diseases keep being the leading cause of mortality in Spain. Efforts should be intensified to identify new risk factors that may contribute to increasing cardiovascular risk.
Velilla Teresa Arrobas, Prendes Carla Fernández, Grau Núria Amigó, Calmarza Pilar, Anguila Silvia Camós, Estébanez Beatriz Candas, Castro María José Castro, Ceacero David, Martínez Irene González, Palencia María Martín, Foncillas José Puzo, Román Carlos Romero,   +12 more
doaj   +1 more source

Free‐Form Microfluidic Microneedle Array Patches

Advanced Functional Materials, EarlyView.
Microfluidic microneedle array patches (MAPs) integrate hollow microneedles with embedded microfluidic channels, fabricated using high‐resolution 3D printing, to enable controlled transdermal delivery of liquid, mixed, or reconstituted therapeutics.
Ian A. Coates, Madison M. Driskill, Netra U. Rajesh, Gabriel Lipkowitz, Dan Ilyn, Yue Xu, Maria T. Dulay, Gunilla B. Jacobson, John R. Tumbleston, Jillian L. Perry, Shaomin Tian, Joseph M. DeSimone   +11 more
wiley   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Unraveling the Heterogeneity of Cargo Distribution in the Exogenous Association of Proteins With Extracellular Vesicles

Advanced Healthcare Materials, EarlyView.
We characterized the distribution of cargo proteins associated with extracellular vesicles using various exogenous loading methods. In all cases, single‐particle analysis revealed that the distribution of protein content per EV is heterogeneous, following an exponential decay function.
Karl Normak, Marcell Papp, Carolina Paganini, Andrea Zendrini, Paolo Bergese, Dorothea Pinotsi, Paolo Arosio   +6 more
wiley   +1 more source

Advanced Oral Delivery Systems for Nutraceuticals

Advanced Healthcare Materials, EarlyView.
Emerging delivery technologies are explored to overcome barriers to oral nutraceutical absorption. Traditional carriers are compared with novel platforms including biodegradable polymers, MOFs, MPNs, and 3D printing. These systems enhance bioavailability, control release, and enable personalized nutrition.
Xin Yang, Linzixuan Zhang, Zhiling Zheng, Robert Langer, Ana Jaklenec   +4 more
wiley   +1 more source