Lipid Nanoparticle‐Mediated CRISPR‐Cas13a Delivery for the Control of Bacterial Infection
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.New formulations of lipid nanoparticles (LNPs) that can deliver nucleic acids to Gram‐negative bacteria are proposed to combat bacterial infection. The delivery of nucleic acids by LNPs is aided by LNP‐helpers which weaken the bacterial outer membrane. LNPs encapsulating the Cas13a/gRNA expression vector achieve an antibacterial effect in both in vivo ...
Bookun Kim +9 more
wiley +1 more source
Characterization of phospholipid-cholesterol bilayers as self-assembled amphiphile block polymers that contain headgroups [PDF]
arXivCholesterol is known to modulate the structure and function of biological membranes. In this study, we use self-consistent field theory (SCFT) to investigate phospholipid/cholesterol bilayer membranes modeled with two types of diblock copolymers. These copolymer-based bilayers serve as biomimetic platforms with applications in areas such as drug ...
arxiv
Age, Serum Cholesterol and Coronary Artery Disease
, 1950 Menard M. Gertler +2 more
openalex +1 more source
The effects of portacaval shunt upon hepatic cholesterol synthesis and cyclic AMP in dogs and baboons [PDF]
, 1980 Hepatic cholesterol synthesis, hepatic cyclic AMP, and portal and peripheral insulin and glucagon levels were investigated in nine dogs and three baboons after complete portacaval shunt.
Benichou, J +3 more
core
Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo +11 more
wiley +1 more source
THE MOLECULAR MICRODISTILLATION OF CHOLESTEROL AND CHOLESTEROL ESTERS
, 1949 Alfred E. Koehler, Elsie Hill
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EFFECT OF THE LEVEL AND TYPE OF DIETARY FAT ON THE METABOLISM OF CHOLESTEROL AND BETA LIPOPROTEINS IN THE CEBUS MONKEY [PDF]
, 1956 Oscar W. Portman +5 more
openalex +1 more source
GeneFishing to reconstruct context specific portraits of biological processes. [PDF]
, 2019 Rapid advances in genomic technologies have led to a wealth of diverse data, from which novel discoveries can be gleaned through the application of robust statistical and computational methods.
Ashuach, Tal +7 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Progestin drugs are loaded into a mesoporous silicon dioxide host by melt‐infiltration. Drugs that decompose at or close to their melting point can be loaded by the addition of cholesterol, which acts as a melting point suppressor. High mass loading of the drug is achieved, and dissolution of the composite is controlled by the nanoscale properties of ...
Geoffrey Hollett +13 more
wiley +1 more source
Genetic dissection in a mouse model reveals interactions between carotenoids and lipid metabolism
Journal of Lipid Research, 2016 Carotenoids affect a rich variety of physiological functions in nature and are beneficial for human health. However, knowledge about their biological action and the consequences of their dietary accumulation in mammals is limited.
Grzegorz Palczewski +4 more
doaj