Results 201 to 210 of about 1,523,799 (296)

Cholesterol tunes lipid bilayer interactions. [PDF]

RSC Adv
Liu W, Zhong J, Yeung PWF, Xiao X, Zhao Z, Jiang H, Zhu Y, Ngai T.   +7 more
europepmc   +1 more source

SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport [PDF]

, 2014
Sokrates Stein, Maaike H. Oosterveer, Chikage Mataki, Pan Xu, Vera Lemos, Rick Havinga, Claudia Dittner, Dongryeol Ryu, Keir J. Menzies, Xu Wang, Alessia Perino, Sander M. Houten, Frauke Melchior, Kristina Schoonjans   +13 more
openalex   +1 more source

Cholesterol May be a Negative Whereas Triglycerides Positive Acute Phase Reactants in the Plasma

, 2021
Mehmet Rami Helvacı, Semih Salaz, Atilla Yalçın, Orhan Ekrem Muftuoglu, Abdulrazak Abyad, Lesley Pocock   +5 more
openalex   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Cholesterol Deficiency Directs Autophagy-Dependent Secretion of Extracellular Vesicles. [PDF]

J Extracell Vesicles
Yaeger JDW, Sengupta S, Walz AL, Morita M, Morgan TK, Vermeer PD, Francis KR.   +6 more
europepmc   +1 more source

The Assembly of GM1 Glycolipid- and Cholesterol-Enriched Raft-Like Membrane Microdomains Is Important for Giardial Encystation [PDF]

, 2015
Atasi De Chatterjee, Tavis L. Mendez, Sukla Roychowdhury, Siddhartha Das   +3 more
openalex   +1 more source

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Predictions for Cholesterol Interaction Sites on the A2A Adenosine Receptor [PDF]

, 2013
Ji Young Lee, Edward Lyman
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Cross-Ancestry Polygenic Prediction: Comparing Methods and Assessing Transferability Across Traits. [PDF]

Genet Epidemiol
Momin MM, Zhou X, Ahmed M, Hyppönen E, Benyamin B, Lee SH.   +5 more
europepmc   +1 more source