Results 241 to 250 of about 1,976,779 (394)

Regulation of sterol metabolism by gut microbiota and its relevance to disease. [PDF]

Gut Microbes
Huang C, Wu Q, Wang J, Cai J, Wang Z, You L, Zhu Z, Ding Y.   +7 more
europepmc   +1 more source

Cholesterol, inflammation and innate immunity

Nature reviews. Immunology, 2015
A. Tall, L. Yvan-Charvet
semanticscholar   +1 more source

Therapeutic Antibodies for Mosquito‐Borne Orthoflavivirus Infections: Discovery, Engineering Approaches, and Advances in mRNA‐Based Delivery Systems

Advanced Therapeutics, EarlyView.
This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli, Lucas Silva Rodrigues, Maria Clara Moura Pinheiro, Sylvia Barbosa Pinhate, Marcelo de Macedo Brígido, Andréa Queiroz Maranhão   +5 more
wiley   +1 more source

Abnormal cholesterol-cholesteryl ester metabolism impairs mouse oocyte quality during ovarian aging. [PDF]

Cell Mol Biol Lett
Zhang S, Guo B, Fang J, Wang S, Liu Y, Wu D, Kang N, Zhang Y, Zhen X, Yan G, Ding L, Sun H, Liu C.   +12 more
europepmc   +1 more source

Synthesis and pharmacokinetic study of a 11C-labeled cholesterol 24-hydroxylase inhibitor using ‘in-loop’ [11C]CO2 fixation method

, 2020
Zhen Chen, Jiahui Chen, Natalia Mast, Jian Rong, Xiaoyun Deng, Tuo Shao, Hualong Fu, Qingzhen Yu, Jiyun Sun, Yihan Shao, Lee Josephson, Thomas Collier, Irina A. Pikuleva, Steven H. Liang   +13 more
openalex   +2 more sources

CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu, Chao Xue, Yang Zhao, Jinjian Sun, Changzhi Zhao, Xu Zhang, Guizhen Zhao, Yaozhong Liu, Hongyu Liu, Yongjie Deng, Ying Wang, Chi Zhang, Yingjie Liu, Linjun Zeng, Ying Yang, Bolun Li, Shusi Ding, Linkang Zhou, Henry Kuang, Zanxin Wang, Wenhao Ju, Haihuan Lin, Jie Lin, Yanhong Guo, Lin Chang, Hongmei Zhao, Jing Wang, Jiandie Lin, Lemin Zheng, Y. Eugene Chen, Jifeng Zhang   +30 more
wiley   +1 more source

Sex and reproductive stage modify the effect of endogenous oestrogens on coronary atherosclerosis in rheumatoid arthritis. [PDF]

RMD Open
Karpouzas GA, Papotti B, Ormseth SR, Palumbo M, Hernandez E, Budoff MJ, Ronda N.   +6 more
europepmc   +1 more source

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

Advanced Science, EarlyView.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang, Pengfei Jiang, Joshua B Stein, Yannan Hou, Chaochen Zhou, Heemin Kang, Ki‐Bum Lee   +6 more
wiley   +1 more source

Mechanism of LEPR-mediated cholesterol metabolism involved in NK cell function suppression under simulated microgravity. [PDF]

NPJ Microgravity
Lv H, Yang H, Guo X, Li J, Xie Y, Jiang C, Shi J, Huang Q, Shao D.   +8 more
europepmc   +1 more source

Rooted in Risk: Genetic Predisposition for Low-Density Lipoprotein Cholesterol Level Associates with Diminished Low-Density Lipoprotein Cholesterol Response to Statin Treatment

, 2016
Roelof A. J. Smit, Iris Postmus, Stella Trompet, Michael R. Barnes, Helen R. Warren, Benoît J. Arsenault, Daniel I. Chasman, L. Adrienne Cupples, G. A. Hitman, Ronald M. Krauss, Xiaohui Li, Bruce M. Psaty, Charles Stein, Jerome I. Rotter, J. Wouter Jukema   +14 more
openalex   +2 more sources