Results 241 to 250 of about 1,863,899 (386)
Development and Validation of Machine Learning‐Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease
Advanced Science, EarlyView.This study constructs a stacked multimodal machine learning model for nonalcoholic fattly liver disease (NAFLD) by integrating genetic and clinical features, and synthesize an in‐silico quantitative marker (ISNLD) that enables personalized risk stratification for intrahepatic and extrahepatic outcomes of high‐risk individuals of NAFLD.Lushan Xiao, Lin Zeng, Jiaren Wang, Chang Hong, Ziyong Zhang, Chengkai Wu, Hao Cui, Yan Li, Ruining Li, Shengxing Liang, Qijie Deng, Wenyuan Li, Xuejing Zou, Pengcheng Ma, Li Liu +14 morewiley +1 more sourceAlnustone Ameliorates Metabolic Dysfunction‐Associated Steatotic Liver Disease by Facilitating Mitochondrial Fatty Acid β‐Oxidation via Targeting Calmodulin
Advanced Science, EarlyView.This study identifies alnustone, a natural compound from Alpinia katsumadai, as a potent therapeutic agent for MASLD and MASH. Alnustone enhances mitochondrial fatty acid β‐oxidation by directly targeting calmodulin, improving liver steatosis, fibrosis, and insulin resistance in vivo.Shourui Hu, Xiaofan Liang, Yiming Qin, Yuxuan Li, Yue Liu, Congcong Liu, Zongxuan Lin, Chunxuan Geng, Yanqi Xu, Daimin Wei, Yingying Qin, Han Zhao, Yuqing Zhang, Zi‐Jiang Chen +13 morewiley +1 more sourceRORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression. [PDF]
Cancer DiscovBleve A, Incerti M, Consonni FM, Garlatti V, Ballerini G, Pandolfo C, Monari MN, Serio S, Pistillo D, Sironi M, Alì C, Manfredi M, Barberis E, Finocchiaro G, Cassatella MA, Panico C, Condorelli G, Sica A. +17 moreeuropepmc +1 more sourcePlasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
The Lancet, 2012 B. Voight, G. Peloso, M. Orho-Melander, R. Frikke-Schmidt, M. Barbalić, M. Jensen, G. Hindy, H. Hólm, E. Ding, T. Johnson, H. Schunkert, N. Samani, R. Clarke, J. Hopewell, John F. Thompson, Mingyao Li, G. Thorleifsson, C. Newton‐Cheh, K. Musunuru, J. Pirruccello, D. Saleheen, Li Chen, A. Stewart, A. Schillert, U. Thorsteinsdóttir, G. Thorgeirsson, Sonia S Anand, J. Engert, T. Morgan, J. Spertus, M. Stoll, K. Berger, N. Martinelli, D. Girelli, P. McKeown, C. Patterson, S. Epstein, J. Devaney, M. Burnett, V. Mooser, S. Ripatti, I. Surakka, M. Nieminen, J. Sinisalo, M. Lokki, M. Perola, A. Havulinna, U. de Faire, B. Gigante, E. Ingelsson, T. Zeller, P. Wild, P. D. de Bakker, O. Klungel, A. H. Maitland‐van der Zee, B. Peters, A. de Boer, D. Grobbee, P. Kamphuisen, V. Deneer, Clara C Elbers, N. Onland-Moret, M. Hofker, C. Wijmenga, W. Verschuren, J. Boer, Y. T. van der Schouw, A. Rasheed, P. Frossard, S. Demissie, C. Willer, R. Do, J. Ordovás, G. Abecasis, M. Boehnke, K. Mohlke, M. Daly, C. Guiducci, N. Burtt, Aarti Surti, Elena Gonzalez, S. Purcell, S. Gabriel, J. Marrugat, J. Peden, J. Erdmann, P. Diemert, C. Willenborg, I. König, M. Fischer, C. Hengstenberg, A. Ziegler, I. Buysschaert, D. Lambrechts, F. Van de Werf, K. Fox, N. E. El Mokhtari, Diana Rubin, J. Schrezenmeir, S. Schreiber, Arne S Schäfer, J. Danesh, S. Blankenberg, R. Roberts, R. McPherson, H. Watkins, A. Hall, K. Overvad, E. Rimm, E. Boerwinkle, A. Tybjaerg-hansen, L. Cupples, M. Reilly, O. Melander, P. Mannucci, D. Ardissino, D. Siscovick, R. Elosúa, K. Stefánsson, C. O’Donnell, V. Salomaa, D. Rader, L. Peltonen, S. Schwartz, D. Altshuler, S. Kathiresan +125 moresemanticscholar +1 more sourceDNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes
Advanced Science, EarlyView.In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He +10 morewiley +1 more sourceTargeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition
Advanced Science, EarlyView.The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang +20 morewiley +1 more source
