Results 251 to 260 of about 2,069,563 (390)

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Quantification of cholesterol incorporation in giant unilamellar vesicles produced by a modified cDICE method.

Soft Matter
Arribas Perez M, Koenderink GH.
europepmc   +1 more source

Atherogenic Dyslipidemia in Children and Adolescents: Current Evidence, Clinical Challenges, and Future Perspectives. [PDF]

J Cardiovasc Dev Dis
Giussani M, Casula M, Orlando A, Parati G, Genovesi S.   +4 more
europepmc   +1 more source

Niacin in Patients with Low HDL Cholesterol Levels Receiving Intensive Statin Therapy

, 2012
P. P. Toth
semanticscholar   +1 more source

Meta‐GWAS of Pig Semen Quality Traits Reveals Conserved Genes Regulating Mammalian Fertility

Advanced Science, EarlyView.
This study incorporated 14 210 individuals to perform a GWAS meta‐analysis of six semen quality traits. The GWAS meta‐analysis identifies 234 GWAS loci associated with semen quality traits. The incorporation with a functional genomics resource explains potential genetic regulation of ∼40% GWAS signals underlying semen quality traits.
Qing Lin, Xiaodian Cai, Zhanming Zhong, Tingting Li, Xinyou Chen, Wondossen Ayalew, Zhiting Xu, Chen Wei, Xiaoke Zhang, Hong Cheng, Zhenyang Zhang, Xuehua Li, Yongjie Tang, Siqian Chen, Jun Zhou, Jinglei Si, Xibo Wu, Chao Ning, Qishan Wang, Yuchun Pan, Yahui Gao, Jiaqi Li, Ying Yu, Zhe Zhang, Yunxiang Zhao, Lingzhao Fang, Zhe Zhang   +26 more
wiley   +1 more source

Associations Between Pepsinogen Levels and Various Health Indicators in a Healthy Guangzhou Population. [PDF]

JGH Open
Chang SQ, Zheng YQ, Liu WL, Chen RF, Hou ZK, Li PW, Chen XH.   +6 more
europepmc   +1 more source

Defective cholesterol clearance limits remyelination in the aged central nervous system

Science, 2018
Ludovico Cantuti-Castelvetri, D. Fitzner, Mar Bosch-Queralt, M. Weil, Minhui Su, Paromita Sen, T. Ruhwedel, M. Mitkovski, G. Trendelenburg, D. Lütjohann, W. Möbius, M. Simons   +11 more
semanticscholar   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Single-cell mapping of cholesterol metabolism reveals FDPS as a therapeutic vulnerability in hepatocellular carcinoma. [PDF]

Cell Oncol (Dordr)
Yang X, Li J, Wang Y, Gao Q, Zhang M.
europepmc   +1 more source

Cholesterol Metabolism [PDF]

The Journal of Laryngology & Otology, 1932
openaire   +2 more sources