Results 251 to 260 of about 1,976,779 (394)

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Remnant Cholesterol is Associated with Blood Pressure Control in US Adults with Hypertension: NHANES 2007-2018 Analysis. [PDF]

Vasc Health Risk Manag
Feng S, Zou S, Tang M, Tian R, Xu Y.
europepmc   +1 more source

Potentiating the antitumour response of CD8+ T cells by modulating cholesterol metabolism

Nature, 2016
Wei Yang, Yibing Bai, Y. Xiong, Jin Zhang, Shuokai Chen, Xiaojun Zheng, Xiangbo Meng, Lunyi Li, Jing Wang, Chenguang Xu, Chengsong Yan, Lijuan Wang, Catharine C. Y. Chang, Ta-Yuan Chang, Ti Zhang, P. Zhou, B. Song, Wanli Liu, Shao-Cong Sun, Xiaolong Liu, Bo-liang Li, Chenqi Xu   +21 more
semanticscholar   +1 more source

CHOLESTEROL BIOSYNTHESIS [PDF]

Nutrition Reviews, 2009
openaire   +2 more sources

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

Advanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang, Chong Han, Yangli Xie, Shoutao Qiu, Shaoyang Zhang, Jingjia He, Zejian Wang, Zhenlin Zhang, Huijuan Liu, Lin Chen, Baojie Li   +10 more
wiley   +1 more source

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Usefulness of Non-High-Density Lipoprotein Cholesterol for Screening Dyslipidemia in Children and Adolescents with Overweight or Obesity: A Single-Center Retrospective Study. [PDF]

Children (Basel)
Nam HK, Kang E, Lee KH, Rhie YJ.
europepmc   +1 more source

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

The Lancet, 2012
B. Voight, G. Peloso, M. Orho-Melander, R. Frikke-Schmidt, M. Barbalić, M. Jensen, G. Hindy, H. Hólm, E. Ding, T. Johnson, H. Schunkert, N. Samani, R. Clarke, J. Hopewell, John F. Thompson, Mingyao Li, G. Thorleifsson, C. Newton‐Cheh, K. Musunuru, J. Pirruccello, D. Saleheen, Li Chen, A. Stewart, A. Schillert, U. Thorsteinsdóttir, G. Thorgeirsson, Sonia S Anand, J. Engert, T. Morgan, J. Spertus, M. Stoll, K. Berger, N. Martinelli, D. Girelli, P. McKeown, C. Patterson, S. Epstein, J. Devaney, M. Burnett, V. Mooser, S. Ripatti, I. Surakka, M. Nieminen, J. Sinisalo, M. Lokki, M. Perola, A. Havulinna, U. de Faire, B. Gigante, E. Ingelsson, T. Zeller, P. Wild, P. D. de Bakker, O. Klungel, A. H. Maitland‐van der Zee, B. Peters, A. de Boer, D. Grobbee, P. Kamphuisen, V. Deneer, Clara C Elbers, N. Onland-Moret, M. Hofker, C. Wijmenga, W. Verschuren, J. Boer, Y. T. van der Schouw, A. Rasheed, P. Frossard, S. Demissie, C. Willer, R. Do, J. Ordovás, G. Abecasis, M. Boehnke, K. Mohlke, M. Daly, C. Guiducci, N. Burtt, Aarti Surti, Elena Gonzalez, S. Purcell, S. Gabriel, J. Marrugat, J. Peden, J. Erdmann, P. Diemert, C. Willenborg, I. König, M. Fischer, C. Hengstenberg, A. Ziegler, I. Buysschaert, D. Lambrechts, F. Van de Werf, K. Fox, N. E. El Mokhtari, Diana Rubin, J. Schrezenmeir, S. Schreiber, Arne S Schäfer, J. Danesh, S. Blankenberg, R. Roberts, R. McPherson, H. Watkins, A. Hall, K. Overvad, E. Rimm, E. Boerwinkle, A. Tybjaerg-hansen, L. Cupples, M. Reilly, O. Melander, P. Mannucci, D. Ardissino, D. Siscovick, R. Elosúa, K. Stefánsson, C. O’Donnell, V. Salomaa, D. Rader, L. Peltonen, S. Schwartz, D. Altshuler, S. Kathiresan   +125 more
semanticscholar   +1 more source

Cholesterol and the Law [PDF]

Circulation, 1973
openaire   +2 more sources

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source