Results 21 to 30 of about 1,863,899 (386)

The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß [PDF]

, 2017
Cholesterol is required for the formation and function of some signalling platforms. In synaptosomes, amyloid-β (Aβ) oligomers, the causative agent in Alzheimer's disease, bind to cellular prion proteins (PrPC) resulting in increased cholesterol ...
Anderson, Bate, Bate, Bate, Baxter, Bryleva, Chan, Chang, Chen, Chen, Chiarini, Chiesa, Dunkley, Gaudreault, Gilch, Giuffrida, Gocze, Gylys, Hammond, Herms, Hosie, Kaneko, Kawarabayashi, Koch, Laurén, Linden, Linetti, Lingwood, Lingwood, London, Maglio, Maxfield, Mc Donald, McLean, Montine, Moskowitz, Mouillet-Richard, Nalefski, Naslavsky, Osborne, Pani, Puglielli, Rajendran, Robinet, Ryan, Schroeder, Selkoe, Shankar, Sharma, Simons, Solforosi, Stahl, Sugiyama, Suzuki, Taraboulos, Walsh, Williamson, Yang   +57 more
core   +1 more source

A randomized controlled trial to evaluate the effects of high Protein Complete (lActo) VEgetaRian (PACER) diet in non-diabetic obese Asian Indians in North India

Heliyon, 2017
In view of the increasing prevalence of obesity in largely vegetarian Asian Indians, it is important to research a high protein, low carbohydrate vegetarian diet.
Swati Bhardwaj, Anoop Misra, Seema Gulati, Shajith Anoop, Vineet Kumar Kamal, Ravindra Mohan Pandey   +5 more
doaj   +1 more source

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

Journal of Clinical Investigation, 2002
Lipid homeostasis in vertebrate cells is regulated by a family of membrane-bound transcription factors designated sterol regulatory element–binding proteins (SREBPs).
J. Horton, J. Goldstein, Michael S. Brown   +2 more
semanticscholar   +1 more source

A Body shape index significantly predicts MRI-defined abdominal adipose tissue depots in non-obese Asian Indians with type 2 diabetes mellitus

BMJ Open Diabetes Research & Care, 2020
Introduction We aimed to determine the correlations of volumes of subcutaneous abdominal adipose tissue (SCAT) (anterior, posterior, superficial and deep), total SCAT, intraperitoneal adipose tissue, retroperitoneal abdominal adipose tissue (RPAT), total
Shajith Anoop, Jesse Krakauer, Nir Krakauer   +2 more
doaj   +1 more source

The differentiation of cholesterol and pigment gallstones [PDF]

, 1989
Gallbladder biles and stones were obtained at 116 cholecystectomies for symptomatic gallstone disease. All 33 patients younger than 50 years had cholesterol stones, whereas 40% of the older patients had pigment stones.
Carey, Holan, Pomeranz, Sackmann, Thistle, Trotman   +5 more
core   +1 more source

Enzymatic determination of total serum cholesterol.

Clinical Chemistry, 1974
An enzymatic method is described for determination of total serum cholesterol by use of a single aqueous reagent. The method requires no prior treatment of sample and the calibration curve is linear to 600 mg/dl. Cholesterol esters are hydrolyzed to free
C. C. Allain, L. Poon, C. Chan, W. Richmond, P. Fu   +4 more
semanticscholar   +1 more source

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.

New England Journal of Medicine, 2020
BACKGROUND Inclisiran inhibits hepatic synthesis of proprotein convertase subtilisin-kexin type 9. Previous studies suggest that inclisiran might provide sustained reductions in low-density lipoprotein (LDL) cholesterol levels with infrequent dosing ...
K. Ray, R. Wright, D. Kallend, W. Koenig, Lawrence A Leiter, F. Raal, Jenna A Bisch, T. Richardson, M. Jaros, P. Wijngaard, J. Kastelein   +10 more
semanticscholar   +1 more source

Association between cholesterol-phospholipid vesicles and cholesterol crystals in human gallbladder bile [PDF]

, 1989
Rapid aggregation of cholesterol-phospholipid vesicles in gallbladder bile seems to be the first event in the production of cholesterol crystals, a prerequisite for cholesterol gallstone formation.
Jüngst, Dieter, Schriever, Carolin Erika   +1 more
core   +1 more source

Randomized Control Trial for Reduction of Body Weight, Body Fat Patterning, and Cardiometabolic Risk Factors in Overweight Worksite Employees in Delhi, India

Journal of Diabetes Research, 2017
Background. We studied the impact of the multicomponent interventions on body weight and cardiometabolic risk factors in overweight individuals working in corporate worksites. Methods.
Usha Shrivastava, Mahrukh Fatma, Smriti Mohan, Padam Singh, Anoop Misra   +4 more
doaj   +1 more source

Gypenosides Prevent and Dissolve Cholesterol Gallstones by Modulating the Homeostasis of Cholesterol and Bile Acids

Frontiers in Medicine, 2022
Gypenosides (GPs), obtained from Gynostemma pentaphyllum (Thunb.) Makino, have been traditionally prescribed to treat metabolic disorders in Asians. This study assessed whether GPs could prevent lithogenic diet (LD)-induced cholesterol gallstone (CG ...
Qian Zhuang, Jinnian Cheng, Jie Xia, Min Ning, Shan Wu, Shuang Shen, Yan Shi, Dan Huang, Zhixia Dong, Xinjian Wan   +9 more
doaj   +1 more source