Results 301 to 310 of about 1,976,779 (394)

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, EarlyView.
This review spotlights the emerging field of vascular aging, providing a comprehensive and critical overview of the molecular processes and clinical manifestations of vascular dysfunction during aging. By combining basic angioscience concepts with a critical analysis of innovative pre‐clinical aging models and lifestyle interventions, it offers a ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Remnant Cholesterol as a Predictor of Target-Vessel Failure in Patients With In-Stent Restenosis. [PDF]

Rev Cardiovasc Med
Kong XH, Lv ZH, Wang YF, Sun YD, Xu T, You W, Meng PN, Wu XQ, Wu ZM, Jia HB, Ye F.   +10 more
europepmc   +1 more source

Effect of Lactic Acid Bacteria on Serum Cholesterol Level in Rats Fed Cholesterol Diet

, 1998
Hideo Hashimoto, Kazuyuki Yamazaki, Yasuko Arai, Manabu Kawase, Fang He, Masataka Hosoda, A. Hosono   +6 more
openalex   +2 more sources

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

HIV-1 Infection of Macrophages Induces Retention of Cholesterol Transporter ABCA1 in the Endoplasmic Reticulum

, 2014
Beda Břicháček, Christina Darwish, Anastas Popratiloff, Larisa Dubrovsky, Michael Bukrinsky   +4 more
openalex   +2 more sources

Cholesterol granuloma

Pathologica
Campora, Michela, Negri, Giampiero, Longari, Virgilio, Ponzoni, Maurilio   +3 more
openaire   +2 more sources

Redox‐Responsive Tellurium‐Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic Cardiomyopathy

Advanced Science, EarlyView.
This study unlocks the immense potential of COF@polymer nanocomposites as a multifunctional therapeutic platform for targeted drug delivery in diabetic cardiomyopathy. Abstract Diabetic cardiomyopathy, a major complication of diabetes, is strongly associated with elevated levels of glycated hemoglobin (HbA1c) and reactive oxygen species (ROS). However,
Jing Xue, Jialu Zhuang, Taotao Fan, Songtao Tang, Junjun Wang, Xiaohui Liu, Jian Liu, Jin Shi, Jiaji Li, Wanjun Li, Danyou Hu, Xiaoqian Zhang, Hua Wang, Guiyang Zhang   +13 more
wiley   +1 more source

Mitochondria relay cholesterol signal exacerbates osteoarthritis in mice. [PDF]

Nat Commun
Ma Y, Pang Y, Liu C, Tian Y, Zheng K, Yao M, Liu X, Cao R, Zhao Y, Zheng Z, Jia W, Zhu D, Peng H, Du D, Qu X, Liu CJ, Yang P, Huang Y, Zhang C, Gao J.   +19 more
europepmc   +1 more source

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li, Eduardo H. Gilglioni, Wadsen St‐Pierre‐Wijckmans, Leila Hosseinzadeh, Christelle Veyrat‐Durebex, Sumeet Pal Singh, Roberto Coppari, Latifa Bakiri, Esteban N. Gurzov   +8 more
wiley   +1 more source