Results 321 to 330 of about 1,802,229 (363)

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source

Dyslipidemia in Children and Adolescents: Current Insights and Updated Treatment Approaches. [PDF]

Pediatr Gastroenterol Hepatol Nutr
Kim SE.
europepmc   +1 more source

LRRC4 Deficiency Drives Premature Ovarian Insufficiency by Disrupting Metabolic Homeostasis in Granulosa Cells

Advanced Science, EarlyView.
LRRC4 deficiency disrupts the metabolic homeostasis of mitochondrial aerobic respiration and glycolysis during GC differentiation by inhibiting the ubiquitination‐mediated degradation of YAP, which ultimately leads to POI. These findings reveal the novel molecular etiology of POI and provide a promising target for prevention and treatment.
Yujie Shang, Yunjun Li, Di Han, Kun Deng, Wei Gao, Minghua Wu   +5 more
wiley   +1 more source

miR-139-5p activates ferroptosis by inhibiting the expression of HMG-CoA reductase to inhibit the progression of glioma. [PDF]

Cell Death Discov
You Z, Wu F, Zheng Y, Yang H, Ye J, Cai H, Luo C, Liu Y, Ke Y, Xu X.   +9 more
europepmc   +1 more source

THE TRANSFORMATION OF CHOLESTEROL-3d TO COPROSTANOL-d. LOCATION OF DEUTERIUM IN COPROSTANOL

, 1956
Robert Rosenfeld, LEON HELLMAN, T. F. Gallagher   +2 more
openalex   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells. [PDF]

Elife
Oqua AI, Chao K, El Eid L, Casteller L, Baxter BP, Miguéns-Gómez A, Barg S, Jones B, Bernardino de la Serna J, Rouse SL, Tomas A.   +10 more
europepmc   +1 more source

Pia Mater‐Penetrable Lipopolymer Nanoparticles for Gliocyte‐Targeted IL‐10 mRNA Therapy Alleviate Paclitaxel‐Induced Peripheral Neuropathy

Advanced Science, EarlyView.
The P6CIT lipopolymer demonstrates superior transfection efficacy in the spinal cord and DRG, as well as enhanced penetration of the pia mater compared to the MC3 ionizable lipid. Intrathecal delivery of P6CIT LPNPs enables effective transfection in the gliocytes in the spinal cord and DRG.
Xinrou Lin, Lingyu Wei, Xiangpen Li, Ling Zeng, Yingsen Tang, Hongjin Wang, Hengjian Lu, Chenguang Li, Hongxuan Wang, Jinjin Chen, Ying Peng   +10 more
wiley   +1 more source

Cholesterol effects on the tumor immune microenvironment: from fundamental concepts to mechanisms and implications. [PDF]

Front Oncol
Lagunas-Rangel FA.
europepmc   +1 more source

Prussian‐Blue Catalysis and NFC Synergy: a Battery‐Free Laser‐Induced Graphene‐Based Platform for Urine Glucose Monitoring at Point‐of‐Care

Advanced Science, EarlyView.
In this study, Merkoçi and his research group present a polymer‐based synthesis to enhance the stability of Prussian blue (PB) nanoparticles. The resulting PB‐infused catalytic hetero‐interface architecture (PB‐CHIA) achieves complete two‐dimensional (2D) and three‐dimensional (3D) substrate coverage (glassy carbon and laser‐induced graphene electrodes)
Sinan Uzunçar, Gabriel Maroli, Massimo Urban, Arben Merkoçi   +3 more
wiley   +1 more source