Results 341 to 350 of about 1,802,229 (363)

GABA and astrocytic cholesterol determine the lipid environment of GABA_AR in cultured cortical neurons. [PDF]

Commun Biol
Yuan Z, Pavel MA, Hansen SB.
europepmc   +1 more source

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

Advanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li, Huihui Yu, Ruixian Tian, Xingxing Wang, Ting Xing, Chenyi Xu, Tengteng Li, Xue Du, Qianqian Cui, Biao Yu, Yunxia Cao, Zongzhi Yin   +11 more
wiley   +1 more source

Hypercapnia Increases Influenza A Virus Infection of Bronchial Epithelial Cells by Augmenting Cellular Cholesterol via mTOR and Akt. [PDF]

Int J Mol Sci
Chen F, Matsuda A, Sporn PHS, Casalino-Matsuda SM.   +3 more
europepmc   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Role of Cholecystectomy on Serum Lipid Profile in Patients With Gallstone Disease at Tertiary Care. [PDF]

Cureus
Prem Sai Reddy G, Ramalakshmi V, Antony AM, Raghupathy T, Guru G.   +4 more
europepmc   +1 more source

LRP8-dependent cholesterol metabolism modulates mTORC1 signaling and apoptotic pathways in multiple myeloma. [PDF]

Cell Death Dis
Wang Y, Lan T, Zhou C, Zhang Q, Liu P.
europepmc   +1 more source

Niemann Pick C1 mistargeting disrupts lysosomal cholesterol homeostasis contributing to neurodegeneration in a Batten disease model. [PDF]

Sci Adv
Appu AP, Bagh MB, Plavelil N, Mondal A, Sadhukhan T, Singh SP, Perkins NJ, Liu A, Mukherjee AB.   +8 more
europepmc   +1 more source

Hypothyroidism consequent to thyroidectomy is associated with elevated remnant lipoproteins and cholesterol enrichment of triglyceride-rich lipoproteins: an observational study. [PDF]

Lipids Health Dis
Post A, Links MH, Zandee WT, Connelly MA, Links TP, Dullaart RPF.   +5 more
europepmc   +1 more source

HDL cholesterol esters mediate the genetic link between sedentary behavior and urological cancers: Insights from mediation and validation analyses. [PDF]

Medicine (Baltimore)
Chen J, Zhao J, Zuo J, Fu Y, Dong H, Shi H, Zhang Y, Wang H, Fu S.   +8 more
europepmc   +1 more source

Impact of distinct insulin index on neoadjuvant treatment of breast cancer: A clinical retrospective study. [PDF]

Medicine (Baltimore)
Zeng Y.
europepmc   +1 more source